{"id":30567,"date":"2019-10-31T21:36:14","date_gmt":"2019-10-31T18:36:14","guid":{"rendered":"https:\/\/prohoster.info\/blog\/ot-algoritmov-do-raka-lektsii-so-shkoly-po-bioinformatike\/"},"modified":"2019-10-31T21:36:14","modified_gmt":"2019-10-31T18:36:14","slug":"ot-algoritmov-do-raka-lektsii-so-shkoly-po-bioinformatike","status":"publish","type":"post","link":"https:\/\/prohoster.info\/cs\/blog\/news\/ot-algoritmov-do-raka-lektsii-so-shkoly-po-bioinformatike","title":{"rendered":"Od algoritm\u016f po rakovinu: p\u0159edn\u00e1\u0161ky ze \u0161koly bioinformatiky","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"OdV l\u00e9t\u011b 2018 se pobl\u00ed\u017e Petrohradu konala ka\u017edoro\u010dn\u00ed letn\u00ed \u0161kola zam\u011b\u0159en\u00e1 na bioinformatiku, na kterou p\u0159ijelo 100 student\u016f a doktorand\u016f, aby se sezn\u00e1mili s bioinformatikou a jej\u00edmi aplikacemi v r\u016fzn\u00fdch oblastech biologie a medic\u00edny. <\/p>\n

Hlavn\u00ed zam\u011b\u0159en\u00ed t\u00e9to \u0161koly bylo na v\u00fdzkum rakoviny, ale prob\u011bhly tak\u00e9 p\u0159edn\u00e1\u0161ky v dal\u0161\u00edch oblastech bioinformatiky, od evoluce po anal\u00fdzu dat jednovrstv\u00e9ho sekvenov\u00e1n\u00ed. B\u011bhem t\u00fddne se \u00fa\u010dastn\u00edci u\u010dili pracovat s daty z nov\u00e9 generace sekvenov\u00e1n\u00ed, programovali v Pythonu a R, pou\u017e\u00edvali standardn\u00ed bioinformatick\u00e9 n\u00e1stroje a r\u00e1mce, seznamovali se s metodami syst\u00e9mov\u00e9 biologie, popula\u010dn\u00ed genetiky a modelov\u00e1n\u00edm l\u00e9k\u016f p\u0159i studiu n\u00e1dor\u016f a mnoho dal\u0161\u00edho. <\/p>\n

N\u00ed\u017ee naleznete videa 18 p\u0159edn\u00e1\u0161ek, kter\u00e9 byly na \u0161kole p\u0159edn\u00e1\u0161eny, v\u010detn\u011b stru\u010dn\u00e9ho popisu a slid\u016f. P\u0159edn\u00e1\u0161ky ozna\u010den\u00e9 hv\u011bzdi\u010dkou \u201e*\u201c jsou dostate\u010dn\u011b z\u00e1kladn\u00ed a daj\u00ed se sledovat bez p\u0159edchoz\u00ed p\u0159\u00edpravy.
\n<\/a><\/noindex>
\n\"Od
\n
\n 1*. Onkogenomika a personalizovan\u00e1 onkologie | Michail Pjatnickij, NII biomedic\u00ednsk\u00e9 chemie <\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Michail stru\u010dn\u011b hovo\u0159il o genomice n\u00e1dor\u016f a o tom, jak pochopen\u00ed evoluce rakovinn\u00fdch bun\u011bk umo\u017e\u0148uje \u0159e\u0161en\u00ed praktick\u00fdch \u00fakol\u016f onkologie. Zvl\u00e1\u0161tn\u00ed pozornost lektor v\u011bnoval vysv\u011btlen\u00ed rozd\u00edlu mezi onkogeny a onkosupresory, metod\u00e1m vyhled\u00e1v\u00e1n\u00ed \u201erakovinn\u00fdch gen\u016f\u201c a izolaci molekul\u00e1rn\u00edch podtyp\u016f n\u00e1dor\u016f. Na z\u00e1v\u011br se Michail zam\u011b\u0159il na budoucnost onkogenomiky a probl\u00e9my, kter\u00e9 by mohly vzniknout.<\/p>\n

\"Od
\n
\n 2*. Genetick\u00e1 diagnostika d\u011bdi\u010dn\u00fdch n\u00e1dorov\u00fdch syndrom\u016f | Andrej Afanasjev, yRisk<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Andrej hovo\u0159il o d\u011bdi\u010dn\u00fdch n\u00e1dorov\u00fdch syndromech a probr\u00e1l jejich biologii, epidemiologii a klinick\u00e9 projevy. \u010c\u00e1st p\u0159edn\u00e1\u0161ky je v\u011bnov\u00e1na ot\u00e1zce genetick\u00e9ho testov\u00e1n\u00ed \u2014 kdo by m\u011bl podstoupit, co se pro to d\u011bl\u00e1, jak\u00e9 obt\u00ed\u017ee se objevuj\u00ed p\u0159i zpracov\u00e1n\u00ed dat a interpretaci v\u00fdsledk\u016f a nakonec, jak\u00fd p\u0159\u00ednos to p\u0159in\u00e1\u0161\u00ed pacient\u016fm a jejich p\u0159\u00edbuzn\u00fdm.<\/p>\n

\"Od
\n
\n 3*. The Pan-Cancer Atlas | Herman Demidov, BIST\/UPF <\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

I p\u0159es desetilet\u00ed v\u00fdzkum\u016f v oblasti genetiky a epigenetiky rakoviny z\u016fst\u00e1v\u00e1 ot\u00e1zka \u201ejak, kde a pro\u010d vznikaj\u00ed n\u00e1dorov\u00e9 syndromy\u201c st\u00e1le ne\u00fapln\u00e1. Jedn\u00edm z d\u016fvod\u016f je pot\u0159eba standardizovan\u00e9 shroma\u017e\u010fov\u00e1n\u00ed a zpracov\u00e1n\u00ed obrovsk\u00e9ho mno\u017estv\u00ed dat pro odhalen\u00ed efekt\u016f mal\u00e9 velikosti, kter\u00e9 jsou obt\u00ed\u017en\u011b zjistiteln\u00e9 v omezen\u00e9 datov\u00e9 sad\u011b (co\u017e je typick\u00fd objem pro v\u00fdzkum v r\u00e1mci jedn\u00e9 nebo n\u011bkolika laborato\u0159\u00ed), ale kter\u00e9 maj\u00ed v souhrnu obrovsk\u00fd v\u00fdznam v tak slo\u017eit\u00e9m a multifaktori\u00e1ln\u00edm onemocn\u011bn\u00ed, jako je rakovina.<\/p>\n

V posledn\u00edch n\u011bkolika letech mnoho nejv\u00fdznamn\u011bj\u0161\u00edch v\u00fdzkumn\u00fdch skupin sv\u011bta, uv\u011bdomuj\u00edc\u00edch si tento probl\u00e9m, za\u010dalo spojovat sv\u00e9 s\u00edly v pokusech o odhalen\u00ed a popis v\u0161ech t\u011bchto efekt\u016f. O jedn\u00e9 takov\u00e9 iniciativ\u011b (The PanCancer Atlas) a v\u00fdsledc\u00edch z\u00edskan\u00fdch v r\u00e1mci pr\u00e1ce tohoto konsorcia laborato\u0159\u00ed, kter\u00e9 byly publikov\u00e1ny ve zvl\u00e1\u0161tn\u00edm \u010d\u00edsle \u010dasopisu Cell, hovo\u0159il Hermann v t\u00e9to p\u0159edn\u00e1\u0161ce.<\/p>\n

\"Od
\n
\n 4. ChIP-Seq ve studiu epigenetick\u00fdch mechanism\u016f | Oleg \u0160pynov, JetBrains Research <\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Regulace exprese gen\u016f se prov\u00e1d\u00ed r\u016fzn\u00fdmi zp\u016fsoby. Ve sv\u00e9 p\u0159edn\u00e1\u0161ce Oleg hovo\u0159il o epigenetick\u00e9 regulaci prost\u0159ednictv\u00edm modifikace histon\u016f, o zkoum\u00e1n\u00ed t\u011bchto proces\u016f metodou ChIP-seq a o zp\u016fsobech anal\u00fdzy z\u00edskan\u00fdch v\u00fdsledk\u016f.<\/p>\n

\"Od
\n
\n 5. Multiomika ve v\u00fdzkumu rakoviny | Konstantin Okonechnikov, N\u011bmeck\u00e9 v\u00fdzkumn\u00e9 centrum pro rakovinu<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Rozvoj experiment\u00e1ln\u00edch technologi\u00ed v molekul\u00e1rn\u00ed biologii umo\u017enil spojit studium \u0161irok\u00e9ho spektra funk\u010dn\u00edch proces\u016f v bu\u0148k\u00e1ch, org\u00e1nech nebo dokonce v cel\u00e9m organismu. Pro nav\u00e1z\u00e1n\u00ed spojen\u00ed mezi komponenty biologick\u00fdch proces\u016f je nutn\u00e9 pou\u017e\u00edt multiomiku, kter\u00e1 spojuje masivn\u00ed experiment\u00e1ln\u00ed data genetiky, transkriptomiky, epigenomiky a proteomiky. Konstantin uvedl n\u00e1zorn\u00e9 p\u0159\u00edklady aplikace multiomiky v oblasti v\u00fdzkumu rakovinn\u00fdch onemocn\u011bn\u00ed se zam\u011b\u0159en\u00edm na pediatrickou onkologii.<\/p>\n

6. Rozmanitost a omezen\u00ed anal\u00fdzy jednotliv\u00fdch bun\u011bk | Konstantin Okonechnikov<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Podrobn\u011bj\u0161\u00ed p\u0159edn\u00e1\u0161ka o sekvenov\u00e1n\u00ed RNA jednotliv\u00fdch bun\u011bk a metod\u00e1ch anal\u00fdzy t\u011bchto dat, stejn\u011b jako o zp\u016fsobech, jak p\u0159ekonat z\u0159ejm\u00e9 a skryt\u00e9 probl\u00e9my p\u0159i jejich studiu.<\/p>\n

\"Od
\n
\n7. Anal\u00fdza dat single-cell RNA-seq | Konstantin Zaitsev, Washington University in St.Louis<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

\u00davodn\u00ed p\u0159edn\u00e1\u0161ka o sekvenov\u00e1n\u00ed jednotliv\u00fdch bun\u011bk. Konstantin diskutuje metody sekvenov\u00e1n\u00ed, obt\u00ed\u017ee b\u011bhem laboratorn\u00ed pr\u00e1ce a bioinformatick\u00e9 anal\u00fdzy a zp\u016fsoby, jak je p\u0159ekonat.<\/p>\n

\"Od
\n
\n8. Diagnostika svalov\u00e9 dystrofie pomoc\u00ed nanopore sekvenov\u00e1n\u00ed | Pavel Avdejev, George Washington University<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Sekvenov\u00e1n\u00ed s vyu\u017eit\u00edm technologie Oxford Nanopore m\u00e1 v\u00fdhody, kter\u00e9 mohou b\u00fdt pou\u017eity k odhalen\u00ed genetick\u00fdch p\u0159\u00ed\u010din onemocn\u011bn\u00ed, jako je svalov\u00e1 dystrofie. Ve sv\u00e9 p\u0159edn\u00e1\u0161ce Pavel hovo\u0159il o v\u00fdvoji pipeline pro diagnostiku tohoto onemocn\u011bn\u00ed.<\/p>\n

\"Od
\n
\n 9*. Grafov\u00e9 zobrazen\u00ed genomu | Ilya Minkin, Penn State University<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Grafov\u00e9 modely umo\u017e\u0148uj\u00ed kompaktn\u011b zobrazit velk\u00e9 mno\u017estv\u00ed podobn\u00fdch sekvenc\u00ed a \u010dasto se pou\u017e\u00edvaj\u00ed v genomice. Ilya podrobn\u011b objasnil, jak\u00fdm zp\u016fsobem se pomoc\u00ed graf\u016f rekonstruuj\u00ed genomov\u00e9 sekvence, jak a pro\u010d se pou\u017e\u00edv\u00e1 de Bruijn\u016fv graf, jak tato \"grafov\u00e1\" metoda zvy\u0161uje p\u0159esnost vyhled\u00e1v\u00e1n\u00ed mutac\u00ed a jak\u00e9 nevy\u0159e\u0161en\u00e9 probl\u00e9my s pou\u017eit\u00edm graf\u016f st\u00e1le p\u0159etrv\u00e1vaj\u00ed.<\/p>\n

\"Od
\n
\n 10*. Z\u00e1\u017eitkov\u00e1 proteomika | Pavel Sinitsyn, Max Planck Institute of Biochemistry (2 \u010d\u00e1sti) <\/b><\/p>\n

Video 1<\/a><\/noindex>, Video 2<\/a><\/noindex> |Prezentace 1<\/a><\/noindex>, Prezentace 2<\/a><\/noindex><\/p>\n

Proteiny jsou odpov\u011bdn\u00e9 za v\u011bt\u0161inu biochemick\u00fdch proces\u016f v \u017eiv\u00e9m organismu, a zat\u00edmco proteomika je jedinou metodou glob\u00e1ln\u00ed anal\u00fdzy stavu tis\u00edc\u016f protein\u016f najednou. \u0160\u00ed\u0159e \u0159e\u0161en\u00fdch probl\u00e9m\u016f je impozantn\u00ed \u2014 od identifikace protil\u00e1tek a antigen\u016f po ur\u010den\u00ed lokalizace n\u011bkolika tis\u00edc protein\u016f. Ve sv\u00fdch p\u0159edn\u00e1\u0161k\u00e1ch Pavel hovo\u0159il o t\u011bchto a dal\u0161\u00edch aplikac\u00edch proteomiky, jej\u00edm sou\u010dasn\u00e9m rozvoji a \u00faskal\u00edch p\u0159i anal\u00fdze dat.<\/p>\n

\"Od
\n
\n 11*. Z\u00e1kladn\u00ed principy molekul\u00e1rn\u00edch simulac\u00ed | Pavel Jakovlev, BIOCAD <\/b><\/p>\n

Video<\/a><\/noindex>\u00a0| Prezentace<\/a><\/noindex><\/p>\n

\u00davodn\u00ed teoretick\u00e1 p\u0159edn\u00e1\u0161ka o molekul\u00e1rn\u00ed dynamice: k \u010demu je pot\u0159eba, co d\u011bl\u00e1 a jak se pou\u017e\u00edv\u00e1 ve v\u00fdvoji l\u00e9\u010div. Pavel se zam\u011b\u0159il na metody molekul\u00e1rn\u00ed dynamiky, vysv\u011btlen\u00ed molekul\u00e1rn\u00edch sil, popis vazeb, pojmy \"silov\u00e9 pole\" a \"integrace\", omezen\u00ed v modelov\u00e1n\u00ed a mnoho dal\u0161\u00edho. <\/p>\n

\"Od
\n
\n 12*. Molekul\u00e1rn\u00ed biologie a genetika | Jurij Barbitov, Institut bioinformatiky <\/b><\/p>\n

Video 1<\/a><\/noindex>, Video 2<\/a><\/noindex>, Video 3<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

\u00davod do molekul\u00e1rn\u00ed biologie a genetiky ve t\u0159ech \u010d\u00e1stech pro studenty a absolventy technick\u00fdch obor\u016f. V prvn\u00ed p\u0159edn\u00e1\u0161ce se diskutuj\u00ed pojmy sou\u010dasn\u00e9 biologie, ot\u00e1zky struktury genomu a vznik mutac\u00ed. Druh\u00e1 se podrobn\u011b zab\u00fdv\u00e1 ot\u00e1zkami fungov\u00e1n\u00ed gen\u016f, procesy transkripce a translace, t\u0159et\u00ed - regulac\u00ed exprese gen\u016f a z\u00e1kladn\u00edmi molekul\u00e1rn\u011b biologick\u00fdmi metodami.<\/p>\n

13*. Principy anal\u00fdzy dat NGS | Jurij Barbitov, Institut bioinformatiky<\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

P\u0159edn\u00e1\u0161ka se zam\u011b\u0159uje na metody sekvenov\u00e1n\u00ed nov\u00e9 generace (NGS), jejich typy a charakteristiky. Lektor podrobn\u011b vysv\u011btluje, jak jsou strukturov\u00e1na data \u201ena v\u00fdstupu\u201c z sekven\u00e1toru, jak se transformuj\u00ed pro anal\u00fdzu a jak\u00e9 existuj\u00ed zp\u016fsoby pr\u00e1ce s nimi.<\/p>\n

\"Od
\n
\n 14*. Pou\u017eit\u00ed p\u0159\u00edkazov\u00e9ho \u0159\u00e1dku, praxe | Gennadij Zaharov, EPAM<\/b><\/p>\n

Video<\/a><\/noindex><\/p>\n

Praktick\u00fd p\u0159ehled u\u017eite\u010dn\u00fdch p\u0159\u00edkaz\u016f v p\u0159\u00edkazov\u00e9m \u0159\u00e1dku Linuxu, voleb a z\u00e1klad\u016f jejich pou\u017eit\u00ed. P\u0159\u00edklady jsou zam\u011b\u0159eny na anal\u00fdzu sekvenovan\u00fdch sekvenc\u00ed DNA. Krom\u011b standardn\u00edch operac\u00ed Linuxu (nap\u0159. cat, grep, sed, awk) se zkoumaj\u00ed utilitky pro pr\u00e1ci se sekvencemi (samtools, bedtools).<\/p>\n

\"Od
\n
\n 15*. Vizualizace dat pro nejmen\u0161\u00ed | Nikita Alexejev, Univerzita ITMO <\/b><\/p>\n

Video<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Ka\u017ed\u00e9mu se stalo ilustrovat v\u00fdsledky sv\u00fdch v\u011bdeck\u00fdch projekt\u016f nebo rozum\u011bt ciz\u00edm diagram\u016fm, grafik\u00e1m a obr\u00e1zk\u016fm. Nikita vypr\u00e1v\u011bl, jak spr\u00e1vn\u011b interpretovat grafy a diagramy, zd\u016fraz\u0148uj\u00edc to podstatn\u00e9; jak kreslit srozumiteln\u00e9 obr\u00e1zky. Lektor tak\u00e9 upozornil, na co se zam\u011b\u0159it p\u0159i \u010dten\u00ed \u010dl\u00e1nku nebo sledov\u00e1n\u00ed reklamn\u00edho videa.<\/p>\n

\"Od
\n
\n 16*. Kari\u00e9ra v bioinformatice | Viktorie Kor\u017eov\u00e1, Max Planck Institute of Biochemistry<\/b><\/p>\n

Video: 1<\/a><\/noindex>, 2<\/a><\/noindex> | Prezentace<\/a><\/noindex><\/p>\n

Viktorie hovo\u0159ila o struktu\u0159e akademick\u00e9 v\u011bdy v zahrani\u010d\u00ed a o tom, na co je t\u0159eba se zam\u011b\u0159it, aby se student bakal\u00e1\u0159sk\u00e9ho, magistersk\u00e9ho nebo doktorandsk\u00e9ho studia mohl vybudovat kari\u00e9ru ve v\u011bd\u011b nebo v pr\u016fmyslu.<\/p>\n

17*. Jak v\u011bdec sestavit CV | Viktorie Kor\u017eov\u00e1, Max Planck Institute of Biochemistry <\/b><\/p>\n

Video<\/a><\/noindex><\/p>\n

Co nechat v CV a co odstranit? Kter\u00e1 fakta budou zaj\u00edmav\u00e1 pro potenci\u00e1ln\u00ed zam\u011bstnavatele a kter\u00e1 rad\u011bji nezmi\u0148ovat? Jak uspo\u0159\u00e1dat informace, aby va\u0161e \u017eivotopis upoutalo pozornost? P\u0159edn\u00e1\u0161ka poskytne odpov\u011bdi na tyto a dal\u0161\u00ed ot\u00e1zky.<\/p>\n

18*. Jak je uspo\u0159\u00e1d\u00e1n trh bioinformatiky | Andrej Afanasjev, yRisk <\/b><\/p>\n

Video<\/a><\/noindex>\u00a0| Prezentace<\/a><\/noindex><\/p>\n

Jak je uspo\u0159\u00e1d\u00e1n trh a kde pracovat jako bioinformatik? Odpov\u011b\u010f na tuto ot\u00e1zku je podrobn\u011b vysv\u011btlena v p\u0159edn\u00e1\u0161ce Andreje.<\/p>\n

<\/p>\n

Konec<\/h4>\n

\nJak jste mo\u017en\u00e1 zaznamenali, p\u0159edn\u00e1\u0161ky na \u0161kole jsou dost \u0161irok\u00e9 co do t\u00e9mat \u2014 od molekul\u00e1rn\u00edho modelov\u00e1n\u00ed a pou\u017e\u00edv\u00e1n\u00ed graf\u016f pro sestavov\u00e1n\u00ed genomu, po anal\u00fdzu jednotliv\u00fdch bun\u011bk a budov\u00e1n\u00ed v\u011bdeck\u00e9 kari\u00e9ry. V Institutu bioinformatiky se sna\u017e\u00edme zahrnout do programu \u0161koly r\u016fznorod\u00e1 t\u00e9mata, abychom pokryli co nejv\u00edce bioinformatick\u00fdch discipl\u00edn, a aby ka\u017ed\u00fd \u00fa\u010dastn\u00edk zjistil n\u011bco nov\u00e9ho a u\u017eite\u010dn\u00e9ho.<\/p>\n

Dal\u0161\u00ed \u0161kola bioinformatiky se uskute\u010dn\u00ed od 29. \u010dervence do 3. srpna 2019 nedaleko Moskvy. N\u00e1bor na \u0161kolu 2019 ji\u017e prob\u00edh\u00e1, do 1. kv\u011btna.<\/a><\/noindex>. T\u00e9matem tohoto roku bude bioinformatika ve v\u00fdzkumu v\u00fdvoje (developmental biology) a st\u00e1rnut\u00ed (aging).<\/p>\n

Pro ty, kte\u0159\u00ed se cht\u011bj\u00ed do hloubky zab\u00fdvat bioinformatikou, pokra\u010duje p\u0159\u00edjem p\u0159ihl\u00e1\u0161ek na n\u00e1\u0161. prezen\u010dn\u00ed ro\u010dn\u00ed program<\/a><\/noindex> v Petrohradu. Nebo sledujte na\u0161e novinky o zah\u00e1jen\u00ed programu v Moskv\u011b u\u017e toto podzim.<\/p>\n

Pro ty, kte\u0159\u00ed nejsou v Petrohradu nebo Moskv\u011b, ale velmi cht\u011bj\u00ed b\u00fdt bioinformatici \u2014 p\u0159ipravili jsme. seznam knih a u\u010debnic<\/a><\/noindex> o algoritmech, programov\u00e1n\u00ed, genetice a biologii.<\/p>\n

Tak\u00e9 m\u00e1me des\u00edtky otev\u0159en\u00fdch a bezplatn\u00fdch online kurz\u016f na Stepik,<\/a><\/noindex>kter\u00e9 m\u016f\u017eete za\u010d\u00edt absolvovat hned te\u010f.<\/p>\n

V roce 2018 se letn\u00ed \u0161kola bioinformatiky konala za podpory na\u0161ich st\u00e1l\u00fdch partner\u016f \u2013 spole\u010dnost\u00ed JetBrains, BIOCAD a EPAM, za co\u017e jim moc d\u011bkujeme. <\/p>\n

V\u0161em bioinformatic\u016fm!<\/b><\/p>\n

P.S. Pokud se v\u00e1m zd\u00e1lo m\u00e1lo, tady je p\u0159\u00edsp\u011bvek s p\u0159edn\u00e1\u0161kami z minul\u00e9 \u0161koly.<\/a><\/noindex> a je\u0161t\u011b n\u011bkolika \u0161kol z p\u0159edminul\u00fdch let.<\/a><\/noindex>.<\/p>\n

\"Od
\n
Zdroj: habr.com<\/a><\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

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