{"id":30803,"date":"2019-10-31T21:37:30","date_gmt":"2019-10-31T18:37:30","guid":{"rendered":"https:\/\/prohoster.info\/blog\/hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk\/"},"modified":"2019-10-31T21:37:30","modified_gmt":"2019-10-31T18:37:30","slug":"hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk","status":"publish","type":"post","link":"https:\/\/prohoster.info\/cs\/blog\/administrirovanie\/hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk","title":{"rendered":"\u201eAhoj\u201c! Prvn\u00ed na sv\u011bt\u011b automatick\u00e9 \u00falo\u017ei\u0161t\u011b dat v molekul\u00e1ch DNA","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\u201eAhoj\u201c!
\n<\/p>\n

V\u00fdzkumn\u00edci z Microsoftu a Washingtonsk\u00e9 univerzity p\u0159edstavili prvn\u00ed pln\u011b automatizovan\u00fd syst\u00e9m pro ukl\u00e1d\u00e1n\u00ed dat v um\u011ble vytvo\u0159en\u00e9 DNA s mo\u017enost\u00ed \u010dten\u00ed. To je kl\u00ed\u010dov\u00fd krok sm\u011brem k p\u0159evodu nov\u00e9 technologie z v\u00fdzkumn\u00fdch laborato\u0159\u00ed do komer\u010dn\u00edch datov\u00fdch center.<\/p>\n

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V\u00fdvoj\u00e1\u0159i potvrdili koncept pomoc\u00ed jednoduch\u00e9ho testu: \u00fasp\u011b\u0161n\u011b zak\u00f3dovali slovo \u201ehello\u201c do fragment\u016f syntetick\u00e9 molekuly DNA a p\u0159evedli ho zp\u011bt na digit\u00e1ln\u00ed data, pomoc\u00ed pln\u011b automatizovan\u00e9ho koncov\u00e9ho syst\u00e9mu, kter\u00fd je pops\u00e1n v \u010dl\u00e1nku<\/a><\/noindex>, publikovan\u00e9m 21. b\u0159ezna v Nature Scientific Reports.<\/p>\n

<\/a><\/noindex>
\nTento \u010dl\u00e1nek na na\u0161ich str\u00e1nk\u00e1ch.<\/a><\/noindex><\/p>\n

V molekul\u00e1ch DNA lze uchov\u00e1vat digit\u00e1ln\u00ed informace s velmi vysokou hustotou, to znamen\u00e1 v fyzick\u00e9m prostoru, kter\u00fd je o mnoho \u0159\u00e1d\u016f men\u0161\u00ed, ne\u017e jak\u00fd zab\u00edraj\u00ed modern\u00ed datov\u00e1 centra. To je jedno z nad\u011bjn\u00fdch \u0159e\u0161en\u00ed pro ukl\u00e1d\u00e1n\u00ed obrovsk\u00e9ho mno\u017estv\u00ed dat, kter\u00e1 sv\u011bt generuje ka\u017ed\u00fd den \u2013 od obchodn\u00edch z\u00e1znam\u016f a vide\u00ed s roztomil\u00fdmi zv\u00ed\u0159aty po l\u00e9ka\u0159sk\u00e9 sn\u00edmky a obr\u00e1zky z vesm\u00edru.<\/p>\n

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Microsoft zkoum\u00e1 zp\u016fsoby, jak p\u0159ekonat potenci\u00e1ln\u00ed rozd\u00edl mezi mno\u017estv\u00edm dat, kter\u00e1 produkujeme<\/a><\/noindex> a chceme uchov\u00e1vat, a na\u0161\u00ed schopnost\u00ed je ulo\u017eit. Mezi takov\u00e9 zp\u016fsoby pat\u0159\u00ed v\u00fdvoj algoritm\u016f a technologi\u00ed molekul\u00e1rn\u00edch v\u00fdpo\u010dt\u016f pro zak\u00f3dov\u00e1n\u00ed dat do um\u011bl\u00fdch DNA<\/a><\/noindex>. To by umo\u017enilo um\u00edstit ve\u0161ker\u00e9 informace ulo\u017een\u00e9 v velk\u00e9m modern\u00edm datov\u00e9m centru do prostoru, kter\u00fd je p\u0159ibli\u017en\u011b velikosti n\u011bkolika hrac\u00edch kostek.<\/p>\n

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\u201eNa\u0161\u00edm hlavn\u00edm c\u00edlem je uv\u00e9st do provozu syst\u00e9m, kter\u00fd pro koncov\u00e9ho u\u017eivatele bude vypadat t\u00e9m\u011b\u0159 stejn\u011b jako jak\u00fdkoli jin\u00fd syst\u00e9m cloudov\u00e9ho ukl\u00e1d\u00e1n\u00ed: \u00fadaje jsou zas\u00edl\u00e1ny do datov\u00e9ho centra a tam ulo\u017eeny, a pot\u00e9 se prost\u011b objevuj\u00ed, kdy\u017e je z\u00e1kazn\u00edk pot\u0159ebuje,\u201c \u0159\u00edk\u00e1 senior researcher Microsoftu Karin Strauss. \u201eK tomu jsme museli prok\u00e1zat, \u017ee m\u00e1 praktick\u00fd smysl z hlediska automatizace.\u201c<\/p>\n

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Informace je uchov\u00e1v\u00e1na v syntetick\u00fdch DNA molekul\u00e1ch vyroben\u00fdch v laborato\u0159i, nikoli v DNA lid\u00ed nebo jin\u00fdch \u017eiv\u00fdch bytost\u00ed, a m\u016f\u017ee b\u00fdt \u0161ifrov\u00e1na p\u0159ed odesl\u00e1n\u00edm do syst\u00e9mu. A\u010dkoli slo\u017eit\u00e9 stroje, jako jsou syntetiz\u00e9ry a sekven\u00e1tory, ji\u017e vykon\u00e1vaj\u00ed kl\u00ed\u010dov\u00e9 \u010d\u00e1sti procesu, mnoho z mezistup\u0148\u016f st\u00e1le vy\u017eaduje ru\u010dn\u00ed pr\u00e1ci v v\u00fdzkumn\u00e9 laborato\u0159i. \"To nen\u00ed vhodn\u00e9 pro komer\u010dn\u00ed vyu\u017eit\u00ed,\" \u0159ekl Chris Takahashi, hlavn\u00ed v\u011bdeck\u00fd pracovn\u00edk na Polu G. Allen School of Computer Science & Engineering na Univerzit\u011b v USA.Paul G. Allen School of Computer Science & Engineering<\/a><\/noindex>).<\/p>\n

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\"V datov\u00e9m centru nemohou b\u011bhat lid\u00e9 s pipetami, p\u0159i takov\u00e9m p\u0159\u00edstupu je p\u0159\u00edli\u0161 vysok\u00e1 pravd\u011bpodobnost lidsk\u00e9 chyby, je to p\u0159\u00edli\u0161 n\u00e1kladn\u00e9 a vy\u017eaduje to p\u0159\u00edli\u0161 mnoho m\u00edsta,\" vysv\u011btlil Takahashi.<\/p>\n

\n

\r\n \"P\u0159ehr\u00e1t\r\n
<\/div>\r\n <\/div><\/center><\/p>\n

Aby m\u011bl tento zp\u016fsob uchov\u00e1v\u00e1n\u00ed dat komer\u010dn\u00ed smysl, je nutn\u00e9 sn\u00ed\u017eit n\u00e1klady jak na synt\u00e9zu DNA \u2013 vytv\u00e1\u0159en\u00ed z\u00e1kladn\u00edch stavebn\u00edch blok\u016f se v\u00fdznamn\u00fdmi sekvencemi, tak na proces sekvenov\u00e1n\u00ed, kter\u00fd je nezbytn\u00fd pro \u010dten\u00ed ulo\u017een\u00fdch informac\u00ed. V\u011bdci tvrd\u00ed, \u017ee v tomto sm\u011bru prob\u00edh\u00e1 rychl\u00fd pokrok<\/a><\/noindex>.<\/p>\n

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Podle v\u011bdc\u016f z Microsoftu je automatizace dal\u0161\u00edm kl\u00ed\u010dov\u00fdm \u010d\u00e1st\u00ed t\u00e9to skl\u00e1da\u010dky, kter\u00e1 umo\u017e\u0148uje organizovat uchov\u00e1v\u00e1n\u00ed dat v komer\u010dn\u00edm m\u011b\u0159\u00edtku a u\u010dinit ho dostupn\u011bj\u0161\u00edm.<\/p>\n

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Za ur\u010dit\u00fdch podm\u00ednek m\u016f\u017ee DNA existovat mnohem d\u00e9le ne\u017e sou\u010dasn\u00e9 prost\u0159edky archivn\u00edho uchov\u00e1v\u00e1n\u00ed, kter\u00e9 se rozpadnou b\u011bhem desetilet\u00ed. N\u011bkter\u00e9 DNA se poda\u0159ilo uchovat v m\u00e9n\u011b ne\u017e ide\u00e1ln\u00edch podm\u00ednk\u00e1ch po des\u00edtky tis\u00edc let \u2013 v mamut\u00edch kl\u016f a v kostech ran\u00fdch lid\u00ed. To znamen\u00e1, \u017ee data lze uchov\u00e1vat t\u00edmto zp\u016fsobem, dokud existuje lidstvo.<\/p>\n

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Automatizovan\u00fd syst\u00e9m ukl\u00e1d\u00e1n\u00ed dat DNA pou\u017e\u00edv\u00e1 software vyvinut\u00fd specialisty Microsoft a Washingtonsk\u00e9 univerzity (UW). Ten p\u0159ev\u00e1d\u00ed jedni\u010dky a nuly digit\u00e1ln\u00edch dat na sekvence nukleotid\u016f (A, T, C a G), kter\u00e9 p\u0159edstavuj\u00ed \"stavebn\u00ed bloky\" DNA. Syst\u00e9m pak vyu\u017e\u00edv\u00e1 cenov\u011b dostupn\u00e9, v\u011bt\u0161inou standardn\u00ed laborato\u0159n\u00ed vybaven\u00ed k dod\u00e1v\u00e1n\u00ed pot\u0159ebn\u00fdch kapalin a reagent\u016f do syntetiz\u00e1toru, kter\u00fd skl\u00e1d\u00e1 vyroben\u00e9 fragmenty DNA a umis\u0165uje je do \u00falo\u017en\u00e9 n\u00e1doby.<\/p>\n

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Kdy\u017e je t\u0159eba informace vyjmout, syst\u00e9m p\u0159id\u00e1v\u00e1 dal\u0161\u00ed chemik\u00e1lie pro spr\u00e1vnou p\u0159\u00edpravu DNA a pou\u017e\u00edv\u00e1 mikrofluidn\u00ed \u010derpadla k posouv\u00e1n\u00ed kapalin do t\u011bch \u010d\u00e1st\u00ed syst\u00e9mu, kter\u00e9 \u010dtou sekvence molekul DNA a p\u0159ev\u00e1d\u011bj\u00ed je zp\u011bt na informace srozumiteln\u00e9 po\u010d\u00edta\u010di. V\u00fdzkumn\u00edci \u0159\u00edkaj\u00ed, \u017ee c\u00edlem projektu nebylo prok\u00e1zat, \u017ee syst\u00e9m m\u016f\u017ee fungovat rychle nebo levn\u011b, ale jednodu\u0161e uk\u00e1zat, \u017ee automatizace je mo\u017en\u00e1.<\/p>\n

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Jednou z nejv\u00edce z\u0159ejm\u00fdch v\u00fdhod automatizovan\u00e9ho syst\u00e9mu ukl\u00e1d\u00e1n\u00ed DNA je to, \u017ee uvol\u0148uje v\u011bdce k \u0159e\u0161en\u00ed slo\u017eit\u011bj\u0161\u00edch probl\u00e9m\u016f, ani\u017e by museli tr\u00e1vit \u010das hled\u00e1n\u00edm lahv\u00ed s reagenty nebo monot\u00f3nn\u00edm p\u0159id\u00e1v\u00e1n\u00edm kapek kapaliny do zkumavek.<\/p>\n

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\"M\u00edt automatizovan\u00fd syst\u00e9m pro vykon\u00e1v\u00e1n\u00ed opakovan\u00e9 pr\u00e1ce umo\u017e\u0148uje pracovn\u00edk\u016fm laborato\u0159\u00ed soust\u0159edit se na vlastn\u00ed v\u00fdzkum a vyv\u00edjet nov\u00e9 strategie, jak zav\u00e1d\u011bt inovace rychleji,\" \u0159ekl v\u00fdzkumn\u00edk z Microsoftu Bihlin Nguyen.<\/p>\n

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T\u00fdm z Laborato\u0159e molekul\u00e1rn\u00edch informa\u010dn\u00edch syst\u00e9m\u016f Molecular Information Systems Lab<\/a><\/noindex> (MISL) ji\u017e prok\u00e1zal, \u017ee m\u016f\u017ee ukl\u00e1dat fotografie ko\u010dek, \u00fa\u017easn\u00e1 liter\u00e1rn\u00ed d\u00edla, video<\/a><\/noindex> a archivy v DNA a tyto soubory vyjmout bez chyb. Dosud se jim poda\u0159ilo ulo\u017eit v DNA 1 gigabyte dat, co\u017e p\u0159ekon\u00e1v\u00e1 p\u0159edchoz\u00ed sv\u011btov\u00fd rekord 200 MB<\/a><\/noindex>.<\/p>\n

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V\u011bdci tak\u00e9 vyvinuli metody pro prov\u00e1d\u011bn\u00ed v\u00fdznamn\u00fdch v\u00fdpo\u010dt\u016f<\/a><\/noindex>, jako je vyhled\u00e1v\u00e1n\u00ed a extrakce pouze obr\u00e1zk\u016f, na kter\u00fdch je jablko nebo zelen\u00fd bicykl, p\u0159i\u010dem\u017e k tomu vyu\u017e\u00edvaj\u00ed samotn\u00e9 molekuly, ani\u017e by p\u0159ev\u00e1d\u011bli soubory zp\u011bt do digit\u00e1ln\u00edho form\u00e1tu.<\/p>\n

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\u201eS d\u016fv\u011brou m\u016f\u017eeme \u0159\u00edci, \u017ee jsme sv\u011bdky zrozen\u00ed nov\u00e9ho typu po\u010d\u00edta\u010dov\u00e9ho syst\u00e9mu, ve kter\u00e9m jsou molekuly pou\u017e\u00edv\u00e1ny pro ukl\u00e1d\u00e1n\u00ed dat a elektronika pro \u0159\u00edzen\u00ed a zpracov\u00e1n\u00ed. Tato kombinace otev\u00edr\u00e1 velmi zaj\u00edmav\u00e9 mo\u017enosti pro budoucnost,\u201c \u0159ekl profesor z Allen School na Washingtonsk\u00e9 univerzit\u011b. Luis Ceze<\/a><\/noindex>.<\/p>\n

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Na rozd\u00edl od v\u00fdpo\u010detn\u00edch syst\u00e9m\u016f zalo\u017een\u00fdch na k\u0159em\u00edkov\u00fdch komponentech mus\u00ed syst\u00e9my pro ukl\u00e1d\u00e1n\u00ed a v\u00fdpo\u010dty zalo\u017een\u00e9 na DNA pou\u017e\u00edvat kapaliny k p\u0159esunu molekul. Ale kapaliny jsou od elektron\u016f svou podstatou odli\u0161n\u00e9 a vy\u017eaduj\u00ed zcela nov\u00e1 technick\u00e1 \u0159e\u0161en\u00ed.<\/p>\n

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T\u00fdm Washingtonsk\u00e9 univerzity ve spolupr\u00e1ci s Microsoftem tak\u00e9 vyv\u00edj\u00ed programovateln\u00fd syst\u00e9m, kter\u00fd automatizuje laboratorn\u00ed experimenty pomoc\u00ed vlastnost\u00ed elekt\u0159iny a vody k p\u0159esunu kapek na m\u0159\u00ed\u017ece elektrod. Kompletn\u00ed sada softwaru a hardwaru, kter\u00e1 nese n\u00e1zev Puddle a PurpleDrop<\/a><\/noindex>, m\u016f\u017ee m\u00edchat, odd\u011blovat, zah\u0159\u00edvat nebo chladit r\u016fzn\u00e9 kapaliny a vykon\u00e1vat laboratorn\u00ed protokoly.<\/p>\n

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C\u00edlem je automatizovat laboratorn\u00ed experimenty, kter\u00e9 jsou v sou\u010dasnosti prov\u00e1d\u011bny ru\u010dn\u011b nebo drah\u00fdmi roboty pracuj\u00edc\u00edmi s kapalinou, a sn\u00ed\u017eit n\u00e1klady.<\/p>\n

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Dal\u0161\u00edmi kroky pro t\u00fdm MISL je integrace jednoduch\u00e9ho pr\u016fchoz\u00edho automatizovan\u00e9ho syst\u00e9mu s technologiemi jako Purple Drop a dal\u0161\u00edmi technologiemi, kter\u00e9 umo\u017e\u0148uj\u00ed vyhled\u00e1v\u00e1n\u00ed v molekul\u00e1ch DNA. V\u011bdci speci\u00e1ln\u011b navrhli sv\u00e9 automatizovan\u00e9 syst\u00e9my jako modul\u00e1rn\u00ed, aby bylo mo\u017en\u00e9 je roz\u0161i\u0159ovat v souladu s nov\u00fdmi technologiemi pro synt\u00e9zu, sekvenov\u00e1n\u00ed a pr\u00e1ci s DNA.<\/p>\n

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\u201eJednou z v\u00fdhod tohoto syst\u00e9mu je to, \u017ee pokud chceme nahradit jednu z \u010d\u00e1st\u00ed n\u011b\u010d\u00edm nov\u00fdm, dokonalej\u0161\u00edm nebo rychlej\u0161\u00edm, m\u016f\u017eeme jednodu\u0161e p\u0159ipojit novou \u010d\u00e1st,\u201c \u0159ekl Nguyen. \u201eTo n\u00e1m d\u00e1v\u00e1 v\u011bt\u0161\u00ed flexibilitu do budoucna.\u201c<\/p>\n

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Horn\u00ed obr\u00e1zek: V\u00fdzkumn\u00edci z Microsoftu a Washingtonsk\u00e9 univerzity zaznamenali a p\u0159e\u010detli slovo \u201e<\/em>hello<\/em>\u201c, pomoc\u00ed prvn\u00edho pln\u011b automatizovan\u00e9ho syst\u00e9mu pro ukl\u00e1d\u00e1n\u00ed dat v DNA. To je kl\u00ed\u010dov\u00fd krok pro p\u0159enos nov\u00e9 technologie z laborato\u0159\u00ed do komer\u010dn\u00edch datov\u00fdch center.<\/em><\/p>\n

Zdroj: habr.com<\/a><\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

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