ʻO ka moeʻuhane o kēlā me kēia kanaka ke noho ʻōpio i ka wā hiki. ʻAʻole makemake mākou e ʻelemakule a maʻi, makaʻu mākou i nā mea āpau - ka maʻi maʻi, ka maʻi Alzheimer, ka puʻuwai puʻuwai, ka hahau ʻana ... ʻO ka manawa kēia e noʻonoʻo ai i hea mai ka maʻi kanesa, inā he pilina ma waena o ka puʻuwai puʻuwai a me Alzheimer's ka maʻi, ka hānau keiki ʻole a me ka nalo ʻana o ka lohe. No ke aha i ʻoi aku ka maikaʻi o nā mea hoʻohui antioxidant i kekahi manawa? A ʻo ka mea nui loa: hiki iā mākou ke ola lōʻihi a me ka maʻi ʻole, a inā pēlā, pehea?
Loaʻa i ko mākou kino nā "pūnaewele ikehu" i kapa ʻia ʻo mitochondria. ʻO lākou ke kuleana no ko mākou olakino a maikaʻi. Ke hana maikaʻi lākou, ʻaʻole mākou nele i ka ikehu. A i ka wā ʻino, loaʻa mākou i nā maʻi. Hōʻike ʻo Kauka Lee Know i kahi mea huna: nā maʻi i ʻike ʻole ʻia i ka ʻike mua ʻana: ka maʻi maʻi, ka maʻi ʻaʻai, schizophrenia, ka luhi mau, ka maʻi Parkinson a me nā mea ʻē aʻe - he ʻano maʻamau.
I kēia lā, ʻike mākou pehea e hoʻomaikaʻi ai i ka hana o ka mitochondria, e hāʻawi ana i ke kino me 90% o ka ikehu. E hāʻawi kēia puke iā ʻoe i ka ʻike hou e pili ana i ka meaʻai, ka nohona, ka ʻai ketogenic, a me nā mea hoʻohui e hoʻihoʻi i ka mitochondria olakino, a no laila mākou.
Wehewehe. ʻO ka maʻi mitochondrial
Ua hilahila wau i ka ʻae ʻana i kēia, akā he mea nānā wau i ka hōʻike ʻoiaʻiʻo "The Bachelor." Ua hauʻoli loa au i ke kolu o ka manawa o ka Season 17 (Ianuali 2013), kahi i hele ai ʻo Sin (ke Bachelor) lāua ʻo Ashley (ka Contender) e hālāwai me ʻelua mau kaikamahine e loaʻa ana i ka maʻi mitochondrial. No ka hapa nui o ʻoukou, inā ʻoe i nānā i ka ʻatikala, ʻo ia kāu hoʻolauna mua i ka mitochondrial syndrome (ʻo ka maʻi mitochondrial he paʻakikī o nā maʻi e pili ana i ka pōʻino congenital i ka mitochondria). Eia nō naʻe, ke aʻo nui ʻia nei kēia pūʻulu o nā maʻi e like me ka hoʻāʻo ʻana o ka genetic a me nā ʻenehana sequencing genetic e maʻalahi, maʻalahi a maʻalahi.
A hiki i ka 80s mua, i ka wā i hoʻopaʻa ʻia ai ka genome mitochondrial kanaka, ʻaʻole kakaikahi nā hōʻike o nā maʻi mitochondrial. Ua loli ke kūlana me ka hiki ke wehewehe i ka mtDNA o nā maʻi he nui. Ua alakaʻi kēia i ka piʻi nui o ka nui o nā maʻi i hōʻike ʻia e loaʻa ana i nā maʻi mitochondrial hoʻoilina. Loaʻa i kā lākou helu ma kahi o hoʻokahi i loko o ʻelima (a i ʻole ʻelua a me ka hapa) tausani kānaka. Maanei ʻaʻole mākou e noʻonoʻo i nā poʻe me nā ʻano maʻi o nā maʻi mitochondrial. Eia kekahi, ua ulu nui ka papa inoa o nā hōʻailona o ka mitochondrial syndrome, e hōʻike ana i ke ʻano chaotic o kēia mau maʻi.
Hōʻike ʻia nā maʻi Mitochondrial e nā kiʻi genetic a me nā kiʻi lapaʻau paʻakikī, e hōʻike ana i kahi hui ʻana o kahi ākea ākea o nā ʻano diagnostic i loaʻa. ʻO nā hiʻohiʻona o ka hoʻoilina ma ʻaneʻi e hoʻolohe a i kekahi manawa ʻaʻole mālama i nā kānāwai Mendel. Ua wehewehe ʻo Mendel i nā hiʻohiʻona o ka hoʻoilina o nā ʻano ma o nā genes DNA nuklea maʻamau. ʻO ka hiki ke ʻike ʻia kahi ʻano genetic a i ʻole he maʻi hoʻoilina e helu maʻalahi ʻia ma ke kumu o ka wānana quantitative o nā hopena o ka māhele ʻana o nā keiki i nā ʻano qualitative like ʻole ma o ka hoʻoilina hoʻoilina o kekahi o nā kope ʻelua o ka gene hoʻokahi mai kēlā me kēia. nā mākua (no ka hopena, loaʻa i kēlā me kēia keiki nā kope ʻelua o kēlā me kēia gene). I nā hihia i hoʻokumu ʻia ai ka mitochondrial syndrome ma muli o kahi kīnā i nā genes nuklea, ʻo nā ʻano hoʻoilina e pili ana i nā lula Mendelian. Eia nō naʻe, ʻelua ʻano genome e hiki ai i ka mitochondria ke hana: DNA mitochondrial (i kau ʻia ma ka laina makuahine) a me DNA nuklea (i hoʻoili ʻia mai nā mākua ʻelua). ʻO ka hopena, ʻokoʻa nā ʻano hoʻoilina mai ka autosomal dominant a i ka autosomal recessive, a me ka lawe ʻana o ka makuahine i nā mea genetic.
ʻOi aku ka paʻakikī o ke kūlana ma muli o ka hiki ʻana o nā pilina paʻakikī ma waena o mtDNA a me nDNA i loko o ke kelepona. ʻO ka hopena, hiki i nā hoʻololi like mtDNA ke hoʻoulu i nā hōʻailona like ʻole i nā kaikaina e noho ana ma ka ʻohana hoʻokahi (he ʻokoʻa paha kā lākou DNA nuklea akā he like ka mtDNA), aʻo ka hoʻololi ʻana hiki ke hōʻike i nā hōʻailona like. Hiki i nā māhoe me ka maʻi like ke loaʻa nā kiʻi maʻi ʻokoʻa loa o ka maʻi (ʻo nā hōʻailona kikoʻī e pili ana i nā ʻiʻo i hoʻopilikia ʻia e ke kaʻina pathogenic), ʻoiai hiki i nā poʻe me nā hoʻololi ke loaʻa i nā hōʻailona like e laina me ke kiʻi maʻi like.
ʻOiaʻiʻo, aia ka nui o ka mtDNA hoʻololi i ka hua o ka makuahine, a ua hōʻole kēia ʻoiaʻiʻo i nā wānana āpau e pili ana i nā hopena o ka hoʻoilina genetic. ʻO ke ʻano o kēia pūʻulu o nā maʻi he ʻano chaotic a hiki ke ʻokoʻa ke ʻano o nā hōʻailona e pili ana i kēia mau maʻi mai ka ʻumi makahiki a hiki i ka ʻumi makahiki a ʻokoʻa hoʻi i waena o nā kaikunāne me nā mutations DNA mitochondrial like. Eia kekahi, i kekahi manawa hiki i ka mitochondrial syndrome ke nalo wale, ʻoiai ʻo ia ka mea (a i ʻole) i hoʻoilina. Akā ʻaʻole liʻiliʻi kēlā mau hihia hauʻoli, a ʻoi aku ka nui o nā maʻi mitochondrial e holomua. Ma ka papaʻaina Hōʻike nā papa 2.2 a me 2.3 i nā maʻi a me nā hōʻailona e pili ana i ka mitochondrial dysfunction, a me nā kumu genetic ma hope o kēia mau maʻi. I kēia manawa, ʻike ka ʻepekema ma luna o 200 mau ʻano o ka mitochondrial mutations. Hōʻike ka noiʻi he nui nā maʻi degenerative i hoʻokumu ʻia e kēia mau ʻano hoʻololi (ʻo ia hoʻi, pono mākou e helu hou i nā maʻi he nui e like me nā maʻi mitochondrial).
E like me kā mākou ʻike, hiki i kēia mau hoʻololi ke hoʻopau i ka mitochondria i ka hana ʻana i ka ikehu, hiki ke hoʻokuʻu a make paha nā cell. Loaʻa i nā pūnaewele a pau (koe naʻe ke koko ʻulaʻula) ka mitochondria, a no laila, pili ka mitochondrial syndrome i nā ʻōnaehana kino multicomponent a ʻokoʻa loa (i ka manawa like a i ʻole ka sequential).
Papa 2.2. Nā hōʻailona, nā hōʻailona a me nā maʻi i hana ʻia e ka mitochondrial dysfunction
Papa 2.3. ʻO nā maʻi kino i hoʻokumu ʻia e ka mitochondrial dysfunction
ʻOiaʻiʻo, ʻoi aku ka nui o ka ikehu ma mua o kekahi. Ke hiki ʻole ke hoʻopiha piha ʻia ka pono o ka ikehu o kekahi okana, hoʻomaka nā hōʻailona o ka mitochondrial syndrome. ʻO ka mea mua, pili lākou i nā hana o ka lolo, ka ʻōnaehana nerve, nā ʻiʻo, ka puʻuwai, nā puʻupaʻa a me nā ʻōnaehana endocrine, ʻo ia hoʻi, nā ʻāpana āpau e pono ai ka nui o ka ikehu no ka hana maʻamau.
ʻO nā maʻi i loaʻa i ka mitochondrial dysfunction
Ke ulu nei ko mākou ʻike i ka hana mitochondrial a me ka dysfunction, ke hoʻomaka nei mākou e hana i kahi papa inoa lōʻihi o nā maʻi e pili ana i ka mitochondrial dysfunction a me ka wehewehe ʻana i nā ʻano hana e ulu ai kēia mau maʻi. Hōʻike kekahi mau haʻawina hou e pili ana ka mitochondrial syndrome i kēlā me kēia 2500 poʻe. Eia nō naʻe, inā e noʻonoʻo pono ʻoe i ka papa inoa ma lalo nei, e ʻae ʻoe me kahi kiʻekiʻe o ka probability, e hoʻopaʻa koke ʻia nā maʻi mitochondrial (congenital a i loaʻa paha) i kēlā me kēia iwakāluakūmālima a i ʻole kēlā me kēia ʻumi o nā ʻāina Komohana.
- ʻAno maʻi diabetes II
- Nā maʻi maʻi ʻaʻai
- ʻO ka maʻi Alzheimer
- Maʻi ʻo Parkinson
- ʻO ka maʻi pilipili bipolar
- ʻO Schizophrenia
- ʻO ka ʻelemakule a me ka decrepitude
- ʻO ka hopohopo kaumaha
- ʻO ka steatohepatitis non-alcoholic
- ʻO ka maʻi Cardiovascular
- Sarcopenia (ka nalo ʻana o ka nui o ka ʻiʻo a me ka ikaika)
- E hoʻokō i ka hoʻomanawanui
- ʻO ka luhi, me ka maʻi luhi mau loa, fibromyalgia a me ka ʻeha myofascial
Ma ka pae genetic, pili nā kaʻina hana paʻakikī me kēia mau mea a pau. Hiki ke hoʻoholo ʻia ka ikaika ikaika o kekahi kanaka ma ka nānā ʻana i nā maʻi congenital o kāna DNA mitochondrial. Akā ʻo kēia wale nō ke kumu hoʻomaka. I ka wā lōʻihi, loaʻa nā hemahema mtDNA i loko o ke kino, a ma hope o ka hele ʻana o kekahi a i ʻole kekahi mea ʻē aʻe i kekahi paepae, hoʻomaka ia e hana a lilo paha i ka degeneration (ʻo kēlā me kēia okana kona paepae ponoʻī o ke ahonui, a mākou e kamaʻilio hou aku ai. ).
ʻO kekahi pilikia ʻē aʻe, ʻo kēlā me kēia mitochondrion i loaʻa i nā kope he ʻumi o ka mtDNA, a ʻo kēlā me kēia cell, kēlā me kēia ʻiʻo, a me kēlā me kēia okana he nui mitochondria. Ma muli o ka nui o nā hemahema i nā kope mtDNA i loko o ko mākou kino. Hoʻomaka ka hana ʻino ʻana o kekahi okana ke ʻoi aku ka nui o ka hapa o ka mitochondria hemahema e noho ana i loko o ia mea ma mua o kahi waiwai. Kapa ʻia kēia hanana ka hopena paepae36. Hoʻopili ʻia kēlā me kēia ʻāpana a me nā ʻiʻo i nā mutation kikoʻī a ua ʻike ʻia e kona paepae mutation ponoʻī, koi koi a me ke kūʻē ʻana i nā radical manuahi. ʻO ka hui pū ʻana o kēia mau mea e hoʻoholo ai i ka hopena o kahi ʻōnaehana ola i nā maʻi genetic.
Inā he 10% wale nō o ka mitochondria i hemahema, hiki i ka 90% o ke koena o nā mea hana ikehu cellular maʻamau ke uku no ka hana ʻole o kā lākou "hoa." A i ʻole, no ka laʻana, inā ʻaʻole koʻikoʻi ka mutation akā pili i ka nui o ka mitochondria, hiki ke hana maʻamau ke kelepona.
Aia kekahi manaʻo o ka hoʻokaʻawale ʻana o ka mitochondria kīnā ʻole: i ka wā e puʻunaue ai ke kelepona, hoʻokaʻawale ʻia kona mitochondria ma waena o ʻelua mau keena kaikamahine. Hiki i kekahi o kēia mau pūnaewele ke loaʻa nā mitochondria mutated a pau, aʻo ka mea ʻē aʻe ke loaʻa i nā "mea kanu mana" piha piha (ʻoiaʻiʻo, ʻoi aku ka nui o nā koho waena). E make nā pūnaewele me ka mitochondria dysfunctional ma o ka apoptosis, ʻoiai e hoʻomau ka hana ʻana o nā cell olakino i kā lākou hana (hoʻokahi wehewehe no ka nalowale koke a me ka manaʻo ʻole o ka mitochondrial syndrome). ʻO ke ʻano o ka ʻokoʻa i ke kaʻina DNA o ka mitochondria (a i ʻole plastids) i loko o ke kino like, pinepine i loko o ka cell hoʻokahi, i ka wā e loaʻa ai i kekahi mitochondria, no ka laʻana, kekahi mau pathological mutation, aʻo nā mea ʻē aʻe ʻaʻole, ua kapa ʻia he heteroplasmy. ʻOkoʻa ka degere o ka heteroplasmy ma waena o nā lālā o ka ʻohana hoʻokahi. Eia kekahi, hiki ke ʻokoʻa ke kiʻekiʻe o ka heteroplasmy i loko o ke kino hoʻokahi e pili ana i kahi okana a i ʻole cell, kahi e alakaʻi ai i kahi ākea ākea o nā hōʻike a me nā hōʻailona o kahi maʻi mitochondrial.
I loko o ke kino o kahi embryo e ulu ana, e like me ka puʻunaue ʻana o nā cell, mitochondria me nā mutations e hoʻopiha i nā ʻāpana a me nā ʻiʻo i ʻokoʻa kekahi i kekahi e pili ana i ko lākou pono ikehu. A inā noho ka mitochondria mutated i nā pūnaewele i nā helu he nui, a lilo i mau hana metabolically active (no ka laʻana, ka lolo a i ʻole ka puʻuwai), a laila loaʻa nā pilikia o ke kino e pili ana i ka maikaʻi o ke ola (inā hiki ke ola). Ma ka ʻaoʻao ʻē aʻe, inā e hōʻiliʻili nui ka nui o ka mitochondria dysfunctional i loko o nā cell me ka haʻahaʻa metabolic rate (e ʻōlelo, i loko o nā ʻili ʻili e hoʻololi mau kekahi i kekahi), a laila ʻaʻole ʻike ka mea lawe i kēlā mitochondria e pili ana i kā lākou genetic predisposition i ka mitochondrial syndrome. Ma ka ʻatikala o The Bachelor i ʻōlelo ʻia ma luna, ʻo kekahi o nā kaikamahine me ka maʻi mitochondrial he mea maʻamau, ʻoiai ʻo kekahi i loaʻa i kahi maʻi koʻikoʻi.
Hoʻokumu ʻia kekahi mau mutations mitochondrial me ka makahiki ma muli o ka hana ʻana o nā radical manuahi i ka wā metabolism maʻamau. ʻO ka mea e hiki mai ana ma muli o nā kumu he nui. No ka laʻana, inā puʻunaue ka cell i hoʻopiha ʻia me ka mitochondria dysfunctional i ka wikiwiki, e like me nā cell stem e hana i ka hana o ka hana hou ʻana o ka ʻiʻo, a laila e hoʻokō ikaika nā mea hana ikehu kīnā i kā lākou hoʻonui. Inā ʻaʻole e puʻunaue hou ka cell nawaliwali (e manaʻo mākou e kamaʻilio nei mākou e pili ana i kahi neuron), a laila e mau nā mutation i loko o kēia cell wale nō, akā naʻe, ʻaʻole ia e kāpae i ka hiki ke kūleʻa ʻole. No laila, ʻo ka paʻakikī o ke kumu genetic o ka mitochondrial syndrome e wehewehe i ka ʻoiaʻiʻo o ka pau ʻana o nā kumu waiwai bioenergetic o ke kino, i kumu ʻia e ka mitochondrial mutations, e hōʻike iā ia iho i loko o kahi ākea o nā maʻi like ʻole a paʻakikī a me nā hōʻailona.
Pono mākou e hoʻomanaʻo he nui nā genes ma waho o ka mtDNA i kuleana no ka hana maʻamau o ka mitochondria. Inā pili ka mutation i nā genes e hoʻopili ana i ka RNA, he koʻikoʻi loa nā hopena. I nā hihia i loaʻa ai i kahi keiki kahi kumu kope mitochondrial mutated i kona hānau ʻana mai kekahi makua (e hoʻomanaʻo ʻo nā kumu transcription he mau protein e hoʻomalu i ke kaʻina hana o ka synthesis mRNA ma kahi DNA matrix ma ka hoʻopaʻa ʻana i nā ʻāpana kikoʻī o DNA), a laila e pau kāna mitochondria. e ʻike i nā hopena pathogenic. Eia nō naʻe, inā pili ka mutation i nā mea kikoʻī kikoʻī i hoʻāla ʻia i loko o kekahi mau ʻōpū a i ʻole nāʻiʻo a i ʻole i ka pane ʻana i ka hoʻokuʻu ʻana o kahi hormone kikoʻī, a laila ʻo ka hopena pathogenic pili wale nō.
ʻO ka laulā ākea o nā maʻi mitochondrial a me kā lākou hōʻike ʻana he pilikia koʻikoʻi ia no nā kauka (ʻo ka theoretical a me ka hana), me ka hiki ʻole ke wānana i ka ulu ʻana o ka mitochondrial syndrome. Nui nā maʻi mitochondrial a paʻakikī ke kapa inoa iā lākou āpau, a ʻaʻole i ʻike ʻia ka nui o lākou. ʻO kekahi mau maʻi degenerative kaulana (nā maʻi o ka ʻōnaehana cardiovascular, ka maʻi kanesa, kekahi ʻano o ka dementia, a me nā mea ʻē aʻe) e pili ana i ka ʻepekema hou i ka mitochondrial dysfunction.
He mea nui ka hoʻomaopopo ʻana ʻoiai ʻaʻohe lāʻau lapaʻau no nā maʻi mitochondrial, hiki i nā poʻe he nui me kēia mau maʻi (ʻoi aku ka poʻe me ka maʻi haʻahaʻa a haʻahaʻa paha) hiki ke ola lōʻihi a hoʻokō. Eia nō naʻe, no kēia mea pono mākou e hana systematically, me ka hoʻohana ʻana i ka ʻike i ʻike ʻia ma kā mākou makemake.
No ka mea kākau
Lee Ike he kauka lāʻau naturopathic laikini mai Kanada, lanakila i nā makana. Ua ʻike nā hoa hana iā ia ma ke ʻano he ʻoihana ʻike, mea hoʻolālā a me ke kauka. Ua paʻa ʻo Lee i nā kūlana ma ke ʻano he loea lapaʻau, loea ʻepekema, a me ka luna o ka noiʻi a me ka hoʻomohala ʻana no nā hui nui. Ma waho aʻe o kāna hana ʻepekema o kāna hui, ʻo ia hoʻi he mea aʻoaʻo ma ka ʻoihana o nā huahana olakino kūlohelohe a me nā mea hoʻohui meaʻai, a lawelawe ʻo ia ma ka papa ʻōlelo aʻoaʻo hoʻoponopono o ka puke ʻo Alive, ka nūpepa olakino heluhelu nui loa ma Kanada. Kāhea ʻo ia i ka home ʻo Greater Toronto Area, kahi āna e noho ai me kāna wahine a me kā lāua mau keiki kāne ʻelua, a makemake nui ʻo ia i ka hoʻolaha ʻana i ke olakino kūlohelohe a me ke kaiapuni.
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No Khabrozhiteley 25% ho'ēmi me ka hoʻohana coupon - Mitochondria
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Source: www.habr.com