I ke kauwela o 2018, ua mālama ʻia kahi kula kauwela makahiki ma bioinformatics kokoke i St. Petersburg, kahi i hele mai ai nā haumāna haʻahaʻa haʻahaʻa 100 a me nā haumāna puka e aʻo i nā bioinformatics a aʻo e pili ana i kona hoʻohana ʻana i nā ʻano o ka biology a me nā lāʻau lapaʻau.
ʻO ka manaʻo nui o ke kula ma ka noiʻi ʻana i ka maʻi kanesa, akā aia nā haʻiʻōlelo ma nā wahi ʻē aʻe o ka bioinformatics, mai ka evolution a hiki i ka nānā ʻana i ka ʻikepili sequencing cell single. I ka holo ʻana o ka pule, ua aʻo nā kāne e hana me ka ʻikepili sequencing o ka hanauna e hiki mai ana, i hoʻolālā ʻia ma Python a me R, hoʻohana i nā mea hana bioinformatics maʻamau a me nā frameworks, ua kamaʻāina i nā ʻano o nā ʻōnaehana biology, nā genetics o ka heluna kanaka a me ka hoʻohālike lāʻau i ka wā e aʻo ai i nā ʻōpū. a he nui aku.
Ma lalo ʻoe e ʻike ai i kahi wikiō o 18 mau haʻiʻōlelo i hāʻawi ʻia ma ke kula, me kahi wehewehe pōkole a me nā kiʻi paheʻe. ʻO nā mea i kaha ʻia me ka asterisk "*" he mea maʻamau a hiki ke nānā ʻia me ka ʻole o ka hoʻomākaukau ʻana.
1*. Oncogenomics a me ka oncology pilikino | ʻO Mikhail Pyatnitsky, Ke Keʻena Noiʻi o Biomedical Chemistry
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Ua kamaʻilio pōkole ʻo Mikhail e pili ana i ka genomics tumor a pehea ka hoʻomaopopo ʻana i ka ulu ʻana o nā cell cancer e hiki ai iā mākou ke hoʻoponopono i nā pilikia kūpono i ka oncology. Ua nānā nui ke kumu aʻo i ka wehewehe ʻana i ka ʻokoʻa ma waena o nā oncogenes a me nā mea hoʻopau ʻoʻo, nā ʻano no ka ʻimi ʻana i nā "gens cancer" a me ka ʻike ʻana i nā ʻano subtypes molecular o nā ʻōpū. I ka hopena, ua hoʻolohe ʻo Mikhail i ka wā e hiki mai ana o ka oncogenomics a me nā pilikia e hiki mai ana.
2*. ʻO ka hōʻailona genetic o nā maʻi maʻi tumora hoʻoilina | Andrey Afanasyev, yRisk
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Ua ʻōlelo ʻo Andrey e pili ana i nā maʻi maʻi maʻi hoʻoilina a nānā i kā lākou biology, epidemiology a me nā hōʻike lapaʻau. ʻO ka hapa o ka haʻiʻōlelo e pili ana i ka pilikia o ka hoʻāʻo genetic - ʻo wai ka mea e pono ai, he aha ka mea i hana ʻia no kēia, he aha nā pilikia e kū mai ana i ka hoʻoili ʻana i ka ʻikepili a me ka unuhi ʻana i nā hopena, a ʻo ka hopena, he aha nā pōmaikaʻi e lawe mai ai i nā maʻi a me ko lākou ʻohana. .
3*. ʻO ka Pan-Cancer Atlas | Keleman Demidov, BIST/UPF
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ʻOiai he mau makahiki o ka noiʻi ʻana ma ke kahua o ka genomics cancer a me ka epigenomics, ʻaʻole paʻa ka pane i ka nīnau "pehea, kahi a me ke kumu e kū mai ai nā maʻi maʻi maʻi." ʻO kekahi kumu o kēia, ʻo ia ka pono o ka loaʻa ʻana a me ka hoʻoponopono ʻana i ka nui o ka ʻikepili i mea e ʻike ai i nā hopena o ka liʻiliʻi liʻiliʻi i paʻakikī ke ʻike ʻia i loko o kahi pūʻulu ʻikepili palena ʻole (ka nui maʻamau no kahi noiʻi i loko o hoʻokahi a i ʻole nā laboratories) , akā, i loko o ka hōʻuluʻulu pāʻani i ke kuleana nui i loko o ia maʻi paʻakikī a multifactorial e like me ke kanesa.
I nā makahiki i hala iho nei, ua hoʻomaka ka nui o nā pūʻulu noiʻi ikaika loa o ka honua, i ʻike i kēia pilikia, e hui pū me nā hoʻāʻo e ʻike a wehewehe i kēia mau hopena āpau. Ua kamaʻilio ʻo Herman e pili ana i kekahi o kēia mau hana (The PanCancer Atlas) a me nā hopena i loaʻa ma ke ʻano he ʻāpana o ka hana o kēia consortium of laboratories a paʻi ʻia ma kahi pukana kūikawā o Cell i kēia aʻo.
4. ChIP-Seq i ke aʻo ʻana i nā mīkini epigenetic | Oleg Shpynov, JetBrains Research
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Hoʻoponopono ʻia ka hōʻike ʻana o ke ʻano ma nā ʻano like ʻole. Ma kāna haʻi'ōlelo, ua'ōleloʻo Oleg e pili ana i ka hoʻoponopono epigenetic ma o ka hoʻololi histone, ke aʻoʻana i kēia mau hana me ka hoʻohanaʻana i keʻano ChIP-seq a me nāʻano no ka nānāʻana i nā hopena i loaʻa.
5. Multiomics i ka noiʻi maʻi maʻi | ʻO Konstantin Okonechnikov, Ke Keʻena ʻImi ʻImi maʻi maʻi Kelemania
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ʻO ka hoʻomohala ʻana i nā ʻenehana hoʻokolohua i loko o ka biology molecular i hiki ke hoʻohui i ke aʻo ʻana i kahi ākea o nā kaʻina hana i loko o nā cell, organs a i ʻole ke kino holoʻokoʻa. No ka hoʻokumu ʻana i nā pilina ma waena o nā ʻāpana o nā kaʻina biological, pono e hoʻohana i nā multiomics, kahi e hui pū ai i ka ʻikepili hoʻokolohua nui mai genomics, transcriptomics, epigenomics a me proteomics. Ua hāʻawi ʻo Konstantin i nā hiʻohiʻona maopopo o ka hoʻohana ʻana i nā multi-omics i ke kahua o ka noiʻi maʻi maʻi me ka nānā ʻana i ka pediatric oncology.
6. Versatility a me nā palena o ka Hoʻokahi Cell Analysis | Konstantin Okonechnikov
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ʻO kahi haʻi'ōlelo kiko'ī e pili ana i ka RNA-seq pūnaewele hoʻokahi a me nāʻano no ka nānāʻana i kēiaʻikepili, a me nā ala e lanakila ai i nā pilikia maopopo a hūnā i ke aʻoʻana iā lākou.
7. ʻIkepili o ka ʻikepili RNA-seq hoʻokahi-cell | Konstantin Zaitsev, ke Kulanui o Wakinekona ma St. Louis
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Haʻiʻōlelo hoʻolauna no ka hoʻokaʻina kelepona hoʻokahi. Kūkākūkā ʻo Konstantin i nā ʻano hana hoʻonohonoho, nā pilikia i ka hana ʻoihana a me ka loiloi bioinformatics, a me nā ala e lanakila ai iā lākou.
8. Ka hōʻoia o ka muscular dystrophy me ka nanopore sequencing | Pavel Avdeev, Ke Kulanui o George Washington
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ʻO ka hoʻohana ʻana i ka ʻenehana Oxford Nanopore he mau mea maikaʻi i hiki ke hoʻohana ʻia e ʻike i nā kumu genetic o nā maʻi e like me ka muscular dystrophy. Ma kāna haʻiʻōlelo, ua kamaʻilio ʻo Pavel e pili ana i ka hoʻomohala ʻana i kahi paipu no ka ʻike ʻana i kēia maʻi.
9*. Hōʻike kiʻi o ka genome | ʻO Ilya Minkin, Pennsylvania State University
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Hāʻawi nā kumu hoʻohālike kiʻi i ka hōʻike paʻakikī o ka nui o nā kaʻina like a hoʻohana pinepine ʻia i ka genomics. Ua ʻōlelo kikoʻī ʻo Ilya e pili ana i ke kūkulu hou ʻana o nā kaʻina genomic me ka hoʻohana ʻana i nā kiʻi, pehea a me ke kumu i hoʻohana ʻia ai ka pakuhi de Bruin, pehea ka nui o ia ʻano "graph" e hoʻonui ai i ka pololei o nā hulina mutation, a me nā pilikia i hoʻopau ʻole ʻia me ka hoʻohana ʻana i nā kiʻi.
10*. proteomic lealea | Pavel Sinitsyn, Max Planck Institute of Biochemistry (2 ʻāpana)
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ʻO nā protein ke kuleana no ka hapa nui o nā kaʻina biochemical i loko o kahi mea ola, a i kēia manawa ʻo proteomics wale nō ke ala no ka nānā ʻana o ka honua i ka mokuʻāina o nā kaukani protein i ka manawa like. He mea kupanaha ka nui o nā pilikia i hoʻoholo ʻia - mai ka ʻike ʻana i nā antibodies a me nā antigens i ka hoʻoholo ʻana i ka localization o kekahi mau kaukani protein. Ma kāna mau haʻiʻōlelo, ua ʻōlelo ʻo Pavel e pili ana i kēia a me nā noi ʻē aʻe o ka proteomics, kona hoʻomohala ʻana i kēia manawa a me nā pitfalls i ka ʻikepili ʻikepili.
ʻumikumākahi*. Nā loina kumu o ka hoʻohālikelike molekula | Pavel Yakovlev, BIOCAD
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ʻO ka ʻōlelo aʻoaʻo kumu mua e pili ana i ka molecular dynamics: no ke aha e pono ai, he aha ia hana a pehea e hoʻohana ʻia ai e pili ana i ka hoʻomohala ʻana i ka lāʻau. Ua hoʻolohe ʻo Pavel i nā ʻano o ka molecular dynamics, ka wehewehe ʻana i nā ikaika molecular, ka wehewehe ʻana i nā pilina, nā manaʻo o ka "ikaika ikaika" a me ka "hoʻohui", nā palena i ka hoʻohālike, a me nā mea hou aku.
12*. Molecular Biology and Genetics | ʻO Yuri Barbitov, Institute of Bioinformatics
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He ʻekolu ʻāpana hoʻolauna i ka molecular biology a me genetics no nā haumāna ʻenekinia a me nā haumāna puka. Kūkākūkā ka haʻiʻōlelo mua i nā manaʻo o ka biology hou, nā pilikia o ke ʻano genome a me ke ʻano o nā mutations. ʻO ka lua e uhi kikoʻī i nā pilikia o ka hana gene, nā kaʻina hana o ka unuhi ʻana a me ka unuhi ʻana, ʻo ke kolu ka uhi ʻana i ka hoʻoponopono ʻana i ka hōʻike gene a me nā ʻano hana biological molecular kumu.
13*. Nā Manaʻo o ka ʻikepili ʻikepili NGS | ʻO Yuri Barbitov, Institute of Bioinformatics
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Hōʻike ka haʻiʻōlelo i nā ʻano hana sequencing lua (NGS), ko lākou ʻano a me nā ʻano. Hōʻike ka mea aʻo i nā kikoʻī pehea e hoʻonohonoho ʻia ai ka ʻikepili "output" mai ka sequencer, pehea e hoʻololi ʻia ai no ka nānā ʻana, a he aha nā ala e hana ai me ia.
14*. Ke hoʻohana nei i ka laina kauoha, hoʻomaʻamaʻa | Gennady Zakharov, EPAM
ʻO kahi hiʻohiʻona kūpono o nā kauoha laina kauoha Linux pono, nā koho a me nā kumu o ka hoʻohana ʻana iā lākou. Ke nānā aku nei nā hiʻohiʻona i ka nānā ʻana i nā kaʻina DNA sequenced. Ma waho aʻe o nā hana Linux maʻamau (no ka laʻana, cat, grep, sed, awk), noʻonoʻo ʻia nā pono hana no ka hana ʻana me nā kaʻina (samtools, bedtools).
15*. ʻIke ʻikepili no nā kamaliʻi | Nikita Alekseev, Ke Kulanui ITMO
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Ua loaʻa i kēlā me kēia kanaka ka ʻike o ka hōʻike ʻana i nā hopena o kā lākou mau papahana ʻepekema a i ʻole ka hoʻomaopopo ʻana i nā kiʻi, nā kiʻi a me nā kiʻi a nā poʻe ʻē aʻe. Ua haʻi ʻo Nikita pehea e wehewehe pono ai i nā kiʻi a me nā kiʻi, e hōʻike ana i ka mea nui mai ia mau mea; pehea e kaha kiʻi akaka. Hoʻoikaika pū ke kumu aʻo i ka mea e nānā ai i ka heluhelu ʻana i kahi ʻatikala a i ʻole ke nānā ʻana i kahi pāʻoihana.
16*. Hana ma Bioinformatics | ʻO Victoria Korzhova, Max Planck Institute of Biochemistry
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Ua ʻōlelo ʻo Victoria e pili ana i ke ʻano o ka ʻepekema hoʻonaʻauao ma waho a me nā mea e pono ai ʻoe e hoʻolohe i mea e kūkulu ai i kahi ʻoihana ma ka ʻepekema a ʻoihana paha ma ke ʻano he haumāna laepua, puka a i ʻole haumāna puka.
17*. Pehea e kākau ai i kahi CV no kahi ʻepekema | ʻO Victoria Korzhova, Max Planck Institute of Biochemistry
He aha ka mea e waiho ai ma ka CV a he aha ka mea e wehe ai? He aha nā ʻoiaʻiʻo e hoihoi i kahi luna lab hiki, a ʻoi aku ka maikaʻi ʻaʻole e haʻi? Pehea ʻoe e hoʻonohonoho ai i ka ʻike e kū ai kāu resume? E hāʻawi ka haʻiʻōlelo i nā pane i kēia a me nā nīnau ʻē aʻe.
18*. Pehea e hana ai ka mākeke bioinformatics | Andrey Afanasyev, yRisk
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Pehea e hana ai ka mākeke a ma hea kahi e hana ai kahi bioinformatician? Hōʻike ʻia ka pane i kēia nīnau i nā kikoʻī, me nā hiʻohiʻona a me nā ʻōlelo aʻo, ma ka haʻiʻōlelo a Andrey.
Ka hopena
E like me kāu i ʻike ai, ākea loa nā haʻiʻōlelo ma ke kula ma nā kumuhana - mai ka hoʻohālike molekala a me ka hoʻohana ʻana i nā kiʻi no ka hui genome, i ka nānā ʻana i nā cell hoʻokahi a me ke kūkulu ʻana i kahi ʻoihana ʻepekema. Ke ho'āʻo nei mākou ma ka Institute of Bioinformatics e hoʻokomo i nā kumuhana like ʻole i loko o ka papahana kula i mea e uhi ai i ka nui o nā aʻo bioinformatics e like me ka hiki, a no laila e aʻo ai kēlā me kēia mea i kahi mea hou a pono.
E mālama ʻia ke kula hou ma bioinformatics mai Iulai 29 a ʻAukake 3, 2019 kokoke i Moscow. . ʻO ke kumuhana o kēia makahiki he bioinformatics i ka biology developmental a me ka noiʻi ʻelemakule.
No ka poʻe makemake e aʻo hohonu i ka bioinformatics, ke ʻae nei mākou i nā noi no kā mākou ma Sana Peteroboro. A i ʻole e hahai i kā mākou nūhou e pili ana i ka wehe ʻana o ka papahana ma Moscow i kēia hāʻule.
No ka poʻe ʻaʻole ma St. Petersburg a i Moscow paha, akā makemake maoli e lilo i bioinformatician, ua hoʻomākaukau mākou i nā algorithms, programming, genetics and biology.
He mau kakini no hoi makou , hiki iā ʻoe ke hoʻomaka i kēia manawa.
Ma 2018, ua mālama ʻia ke kula kauwela ma bioinformatics me ke kākoʻo o kā mākou mau hoa hana maʻamau - nā hui ʻo JetBrains, BIOCAD a me EPAM, no laila mākou e mahalo nui ai iā lākou.
Bioinformatics a pau!
PS Inā ʻaʻole ʻoe i manaʻo ua lawa ia, и .
Source: www.habr.com