Cia kuv pib los ntawm kev hais tias kuv tsis yog ib tug anti-vaxxer kiag li, heev opposite. Tab sis cov tshuaj tiv thaiv txawv ntawm cov tshuaj tiv thaiv, tshwj xeeb tshaj yog tam sim no thiab tawm tsam tus kab mob uas paub zoo. Yog li, peb muaj dab tsi rau hnub no?
Gamaleevsky Sputnik V. Ib qho tshuaj tiv thaiv zoo heev thiab niaj hnub no, tsuas yog kev kho noob hauv nws daim ntawv ntshiab yog ua ntej. Nws tsis yog qhov xav tsis thoob tias kev siv zog ntau, sijhawm thiab nyiaj txiag tau nqis peev ntawm no. Nws tseem yog ib tug ua tau nyob rau hauv peb lub teb chaws. Nws cov txiaj ntsig pom tseeb: qhov siab tshaj plaws tiv thaiv kab mob (ntxiv rau cov tshuaj tiv thaiv kab mob, peb muaj kev tiv thaiv ntawm tes) nrog cov kev mob tshwm sim tsawg heev. Tab sis muaj ib tug nuance uas, vim li cas, yog tham txog heev, tsawg heev, thiab ntawm chav kawm tsis nyob rau hauv xov xwm, tab sis nyob rau hauv tshwj xeeb kev kho mob pej xeem. Tam sim no kuv yuav piav qhia qhov kuv tab tom tham txog.
Cov tshuaj tiv thaiv no yog ib hom kab mob adenovirus hloov kho, los yog ob qho tib si neutralized adenoviruses (serotypes 5 thiab 26), uas tau nkag mus rau hauv lub cev nrog lub sijhawm ntawm 3 lub lis piam. Tus kab mob coronavirus spike protein noob yog tsim rau hauv txhua genome. Qhov tseem ceeb, cov no yog "tshuab" uas nws txoj haujlwm yog xa ib qho tseem ceeb "tus neeg caij tsheb" mus rau nws qhov chaw. Thiab tom qab ntawd txhua yam mus raws li qhov xav tau: tus kab mob adenovirus xa cov kab mob coronavirus mus rau hauv cov hlwb, tshem tawm qhov ntawd thiab pib tsim cov protein "neeg caij tsheb" thiab nws tus kheej. Cov khoom ntawm cov protein no raug nthuav tawm los ntawm cov kab mob ntawm tes, yog li kev cob qhia T-lymphocytes. Tom qab "lub Hoobkas cell" raug rhuav tshem, cov kab mob kis kab mob (xws li cov proteins, thiab tsis yog virions npaj kom kis cov hlwb tshiab, xws li hauv cov kab mob) nkag mus rau hauv cov ntshav, yog li txhawb kev tsim cov tshuaj tiv thaiv. Nws yog tsis yooj yim sua kom mob, kev tiv thaiv yog tsim, thiab txhua yam zoo li zoo. Tab sis qhov tshwm sim ntawm cov tshuaj tiv thaiv no yog kev txhim kho ntawm lub cev tiv thaiv kab mob rau cov khoom adenoviral ntawm vector lawv tus kheej. Raws li qhov tshwm sim ntawm kev rov hais dua, "lub tsheb nrog tus neeg caij tsheb" tsuas yog yuav tsis muaj sijhawm mus rau ntawm lub xovtooj, tab sis yuav raug rhuav tshem tam sim ntawd los ntawm cov tshuaj tiv thaiv uas tau tsim los ntawm yav dhau los "kev paub". Nws hloov tawm tias Satellite V tuaj yeem siv tau ib zaug xwb. Thiab qhov no yog qhov tsis txaus ntseeg tsis tsuas yog nrog qhov tseeb tias cov tshuaj tiv thaiv tsis tuaj yeem siv rau nws lub hom phiaj - lub zog ntawm kev tiv thaiv kab mob coronavirus tseem tsis tau paub rau leej twg, thiab zoo li muaj cov neeg mob rov ua dua, tab sis lawv muaj tsawg. Kev txwv txoj sia nyob mus ib txhis rau ib qho kev kho mob adenovector noob, suav nrog kev kho mob ntawm oncology uas yuav xav tau yav tom ntej, yog qhov txaus ntshai. Tag nrho cov no yog tam sim no nquag tsim, thiab tom qab xws li "kev sim loj", txhua yam yuav mus sai dua. Tab sis ib zaug ntxiv, txoj kev kho no yuav los yog tsis muaj txiaj ntsig, tab sis kev tiv thaiv kab mob yog xav tau niaj hnub no. Yog li ntawd, ntawm no txhua leej txhua tus xaiv rau lawv tus kheej yam twg tseem ceeb dua rau lawv. Cov tshuaj tiv thaiv tau zoo li qub, tsuas yog rau cov neeg laus xwb. Tab sis yog tias kuv yog cov tub ntxhais hluas (lawv muaj txhua txoj hauv kev siv cov tshuaj kho noob rau yav tom ntej), kuv yuav xav txog ob zaug.
Kuv hnov txog kev txhim kho ntawm Sputnik-Lite version, rau cov neeg uas tiv thaiv lawv (daim duab) tiv thaiv. Qhov no yuav yog ib qho tshuaj tiv thaiv ib leeg ua raws li ib qho serotype nkaus xwb. Qhov kev xaiv no zoo dua, tab sis nws qhov kev tso tawm tsis tau npaj kom txog thaum Lub Kaum Ob Hlis 2021.
Ob qhov tshuaj tiv thaiv Lavxias ntxiv: EpiVacCorona los ntawm lub chaw Vector (ua los ntawm cov kab mob kis kab mob) thiab tag nrho cov tshuaj tiv thaiv virion los ntawm Chumakov center (ua los ntawm tag nrho cov kab mob) twb tau mus lawm. Ob leeg yog ua raws li txoj kev qub. Muaj kev xav tias nws yog vim li no uas lawv tau poob rau qhov tsis ua haujlwm, thiab tseem vim tias lawv tsis qhib T-cell tiv thaiv kab mob, uas tsis txias tam sim no. Tam sim no me ntsis txog txhua tus, txij li ntau txog lawv tseem tsis paub. Pom tau tias lawv PR yog li ntawd, lossis tej zaum nws tsuas yog tub rog zais cia.
Cov tshuaj tiv thaiv Chumakov tag nrho-virion yog classic, zoo tib neeg loj hlob nrog. Ntawm no, ib tus kab mob tag nrho yog siv, uas tsim kev tiv thaiv kev tiv thaiv, raws li nws muab tag nrho cov antigens. Tab sis tus kab mob no tuag lawm, yog li lub cev tiv thaiv kab mob tsuas yog cov tshuaj tiv thaiv, tab sis nws yuav muaj zog, thiab cov tshuaj tiv thaiv yuav muaj zog. Nws hnyav me ntsis, tab sis thaum muaj kev sib kis nws tsim nyog, tshwj xeeb tshaj yog rau cov neeg noj qab haus huv, xav tau thiab siab tawv. Ntawm tag nrho cov kev nplua nuj ntawm kev xaiv, kuv xav tau nws vim yog kev nkag siab txog kev tsim cov kev tiv thaiv. Tab sis tam sim no nws tsuas yog nyob rau hauv lub siab. Nws tseem tsis tau muaj npe. Tab sis kev tsim khoom loj yog npaj rau lub Peb Hlis. Tos thiab pom.
Cov tshuaj tiv thaiv Lavxias thib peb yog EpiVacCorona los ntawm Vector center. Nws tsis muaj cov kab mob lom ntawm tus kab mob txhua, tab sis tsuas yog nws cov proteins uas tsim los, thiaj li tsis ua kom peb lub hlwb ua haujlwm thiab lim txhua. Cov tshuaj tiv thaiv yog me me, tsis muaj kev phiv, tab sis kuj tsis muaj kev tiv thaiv zoo. Cov tshuaj tiv thaiv Peptide uas tsim kom muaj kev tiv thaiv ntev ntev, tseem tsis tau tsim. Yog li ntawd, txhawm rau txhim kho lub cev tiv thaiv kab mob, cov tshuaj adjuvants tau siv rau hauv lawv. Ntawm no yog aluminium hydroxide. Kuv tsis paub tias qhov no zoo lossis phem, tab sis nws ntseeg tias tsawg dua "cov khoom xyaw" hauv cov tshuaj tiv thaiv, qhov zoo dua. Tab sis nrog cov tshuaj tiv thaiv Vector, tsis zoo li Sputnik V, nws yuav muaj peev xwm txhaj tshuaj tiv thaiv tus neeg tsis kawg. Nws kuj tau sim rau cov neeg laus (65+) thiab cov menyuam yaus (14-17), nrog rau cov neeg muaj kab mob ntev. Lawv sim faib lub ncuav qab zib. Hais txog menyuam yaus, kuv pom zoo, tab sis hais txog cov neeg laus, kuv tsis paub meej. Tam sim no lawv xav tau kev tiv thaiv RELIABLE sai sai. Cov tshuaj tiv thaiv yuav tsum tau mus rau hauv kev ncig thaum pib ntawm lub xyoo. Kuv xav tias nws twb muaj nyob rau qhov twg?
Zoo, thiab cov tshuaj tiv thaiv txawv teb chaws tseem ceeb, peb yuav nyob qhov twg yam tsis muaj lawv? Ua los ntawm adenovector technologies: Suav CanSino Biological Cov. Ua los ntawm 5th serotype ntawm adenovirus, uas muaj ntau heev hauv cov pejxeem. Nws ntseeg tau tias 30% ntawm cov tib neeg twb muaj kev tiv thaiv rau nws, yog li cov tshuaj tiv thaiv yuav tsis zoo rau lawv. American Johnson&Johnson - raws li serotype 26. Hom kab mob no tsis tshua muaj, tab sis tseem muaj qhov ua tau. Yog li ntawd, Sputnik coj ob lub platform ib zaug, tsuas yog kom paub tseeb! Cov tshuaj tiv thaiv British-Swedish AstraZeneca / oxford. Tam sim no qhov xaj tshaj plaws hauv ntiaj teb. Kwv yees li 3 billion koob tshuaj twb tau xaj lawm. Nws yog tsim los ntawm lub hauv paus ntawm chimpanzee adenovirus. Qhov no, ntawm chav kawm, muab 100% lav tias tib neeg lub cev tiv thaiv kab mob tsis tau ntsib tus kab mob no ua ntej thiab yuav tsis ntsib nws dua, tab sis zoovirus thaum muaj kev hloov pauv tuaj yeem tsim cov txiaj ntsig tsis xav txog hauv tib neeg lub cev, uas nyob rau hauv nws tus kheej. yog xyov ceeb.
Ob lub ntiaj teb forwards tau ua raws li mRNA technologies: Pfizer BioNTech thiab Moderna. Qhov no yog ib qho kev taw qhia tshiab kiag li, uas tam sim no tsuas yog lub pinnacle ntawm pharmacology. Ua ntej no, tsis muaj tshuaj tiv thaiv mRNA. Lub tshuab yog me ntsis zoo ib yam li vector technology, tab sis txawv. Tsis muaj cov kab mob thib peb, thiab "tshuab" yog cov khoom tsim tawm lipid nanoparticle, uas yooj yim nkag mus rau hauv daim nyias nyias ntawm peb lub hlwb, thiab "tus neeg caij tsheb" yog tib lub noob lossis mRNA encoding tus kabmob coronavirus. Hauv qhov no, cov hlwb uas mRNA nkag mus tsis raug rhuav tshem, thiab cov protein tsuas yog maj mam tawm, tsim T-cell zoo thiab tiv thaiv kab mob. Txhua yam zoo li zoo, tab sis dua muaj nuances. Ua ntej, nws yog polyethylene glycol, uas yog siv los ua kom ruaj khov mRNA nrog rau qhov kub thiab txias (txog -70), uas nws tus kheej yog ib qho ua xua thiab tuaj yeem ua rau muaj kev cuam tshuam loj heev, suav nrog kev poob siab anaphylactic. Thiab qhov thib ob, cov no yog qhov kev npaj txhij txog tshaj plaws ntawm peb "neeg nrog caij". Thiab yog tias lub hom phiaj ntawm tus kab mob adenovirus yog cov hlwb tshwj xeeb, feem ntau cov hlwb ntawm cov kab mob ua pa sab saud, qhov twg cov kab mob coronavirus tau xa mus rau hauv cov tshuaj tiv thaiv adenovector, ces qhov twg tus mob coronavirus mRNA yuav raug xa los ntawm lipid nanoparticles - tsuas yog Vajtswv paub. Thiab cov no tuaj yeem sib txawv kiag li qhov chaw uas lawv yuav tau ua haujlwm: cov hlab ntsha, pob qij txha, paj hlwb, thiab lwm yam. Cov kev mob tshwm sim twb paub nyob rau hauv daim ntawv ntawm ntau yam autoimmune txheej txheem, ib ntus tuag tes tuag taw, thiab lwm yam. Koj tsis tas yuav saib deb. , tag nrho Is Taws Nem yog rov qab nrog cov kev mob tshwm sim los ntawm Pfizer. Tab sis cov tshuaj tiv thaiv tsis raug tshem tawm ntawm kev siv. Yog li yuav ua li cas yog tias koj taug kev ncig me ntsis nrog lub ntsej muag distorted? Qhov no tsis piv rau qhov kev mob hnyav ntawm Covid, txoj cai? Tab sis cov tshuaj tiv thaiv rau "tshuab" no tsis tsim, tab sis tsuas yog rau "tus neeg caij tsheb". Feem ntau, muaj qee yam xav txog.
Cov tshuaj tiv thaiv Asmeskas Novavax yog tsim los ntawm cov protein sib xyaw ua ke. Cov tshuaj tiv thaiv muaj qhov thib ob ntawm cov koob tshuaj ntau tshaj plaws hauv ntiaj teb. Yog li ntawd nws yog dab tsi? Thiab nyob rau hauv qee qhov tshwj xeeb thev naus laus zis ntawm "kev sib sau" cov protein sib xyaw ua ke rau hauv nanoparticles, ua tsaug rau qhov kev tiv thaiv kab mob ntawm cov protein nce, thiab tseem nyob rau hauv thawj adjuvant Matrix-M. Zoo, uas yog tag nrho rau tam sim no.
Sinovac yog lwm qhov tshuaj tiv thaiv hauv Suav teb. Nws yog tag nrho-virion, uas piav qhia nws qhov chaw. Cov xwm txheej cia li ib txwm thiab kev nkag siab txog kev tsim cov kev tiv thaiv tuaj yeem ua rau muaj nyob hauv ntau lub tebchaws. Raws li cov txiaj ntsig ntawm thawj ob theem ntawm kev sim, nws tau suav hais tias yog ib qho kev cog lus zoo tshaj plaws, tab sis nyob rau hauv qhov kev tshwm sim ib ntus ntawm theem thib peb, cov tshuaj tiv thaiv pom tsuas yog 50% kev ua tau zoo. Kuv xav tias qhov no tuaj yeem ntseeg tau?
Cas zoo li no. Ib yam yog qhov tseeb tias tsis muaj cov tshuaj tiv thaiv zoo tshaj plaws hauv ntiaj teb tam sim no, tab sis tsis ntev los sis tom qab qee qhov kev txiav txim siab tseem yuav tsum tau ua. Txawm li cas los xij, kuv xav kom txhua tus noj qab haus huv thiab muaj zog tiv thaiv!
Tau qhov twg los: www.hab.com