Yuav luag txhua tus ntawm peb tau hnov lossis nyeem cov xov xwm hais txog tus kabmob coronavirus. Ib yam li lwm yam kab mob, kev kuaj mob ntxov yog qhov tseem ceeb hauv kev tawm tsam tus kab mob tshiab. Txawm li cas los xij, tsis yog txhua tus neeg muaj tus kab mob tuaj yeem pom cov tsos mob tib yam, thiab txawm tias lub tshav dav hlau scanners tsim los kuaj pom cov tsos mob ntawm tus kab mob tsis tas yuav txheeb xyuas tus neeg mob ntawm cov neeg coob coob. Cov lus nug tshwm sim: yog vim li cas tib tus kab mob tshwm sim nws tus kheej txawv ntawm cov neeg sib txawv? Lawm, thawj cov lus teb yog kev tiv thaiv. Txawm li cas los xij, qhov no tsis yog tib qho tseem ceeb uas cuam tshuam rau qhov hloov pauv ntawm cov tsos mob thiab qhov hnyav ntawm tus kab mob. Cov kws tshawb fawb los ntawm University of California thiab Arizona (USA) tau pom tias lub zog ntawm kev tiv thaiv kab mob tsis yog nyob ntawm seb hom kab mob khaub thuas twg ib tus neeg tau muaj thoob plaws hauv nws lub neej, tab sis kuj nyob ntawm lawv cov kab ke. Cov kws tshawb fawb tau tshawb pom dab tsi tiag tiag, cov txheej txheem twg tau siv hauv txoj kev tshawb fawb, thiab txoj haujlwm no yuav pab tau li cas hauv kev tawm tsam kev sib kis? Peb yuav pom cov lus teb rau cov lus nug no hauv tsab ntawv ceeb toom ntawm pab pawg tshawb fawb. Mus.
Kev tshawb fawb hauv paus
Raws li peb paub, mob khaub thuas tshwm sim nws tus kheej txawv ntawm cov neeg sib txawv. Ntxiv nrog rau tib neeg qhov tseem ceeb (lub cev tsis muaj zog, noj tshuaj tiv thaiv kab mob, kev tiv thaiv kab mob, thiab lwm yam), ib qho tseem ceeb yog tus kab mob nws tus kheej, los yog nws cov subtype, uas kis tau rau tus neeg mob. Txhua hom subtype muaj nws tus yam ntxwv, nrog rau qhov twg cov pab pawg neeg sib txawv cuam tshuam. Cov kws tshawb fawb tau sau tseg tias cov kab mob H1N1 ("swine flu") thiab H3N2 (Hong Kong flu) kab mob, uas tau dhau los ua ntau tshaj tam sim no, cuam tshuam rau cov neeg muaj hnub nyoog sib txawv: H3N2 ua rau muaj mob hnyav tshaj plaws ntawm cov neeg laus, thiab tseem raug ntaus nqi rau feem ntau ntawm cov neeg tuag; H1N1 tsis tshua muaj neeg tuag tab sis feem ntau cuam tshuam rau cov hnub nyoog nruab nrab thiab cov hluas.
Cov kev sib txawv no yuav yog vim qhov sib txawv ntawm tus nqi ntawm evolution ntawm tus kab mob lawv tus kheej thiab qhov txawv ntawm kev tiv thaiv kab mob * nyob rau hauv cov me nyuam.
Immune imprinting * - ib hom kev nco mus ntev ntawm lub cev tiv thaiv kab mob, tsim los ntawm kev paub txog kab mob hauv lub cev thiab nws cov kev cuam tshuam rau lawv.
Nyob rau hauv txoj kev tshawb no, cov kws tshawb fawb tau tshuaj xyuas cov ntaub ntawv kab mob sib kis los txiav txim seb qhov kev luam ntawv me nyuam yaus puas cuam tshuam rau kev sib kis ntawm tus mob khaub thuas raws caij nyoog thiab, yog tias muaj, seb nws puas ua haujlwm feem ntau los ntawm homosubtypic * tiv thaiv kab mob los yog dhau qhov dav heterosubtypic * nco.
Homosubtypic tiv thaiv * - Kab mob khaub thuas raws caij nyoog A kab mob txhawb kev txhim kho kev tiv thaiv kab mob tiv thaiv kab mob tshwj xeeb.
Heterosubtypic tiv thaiv * - Kev kis kab mob khaub thuas raws caij nyoog A kab mob txhawb kev txhim kho kev tiv thaiv kab mob tiv thaiv kab mob sib kis tsis cuam tshuam nrog tus kab mob no.
Hauv lwm lo lus, tus menyuam txoj kev tiv thaiv kab mob thiab txhua yam uas nws tau ntsib tawm ntawm nws lub cev tiv thaiv kab mob rau lub neej. Cov kev tshawb fawb yav dhau los tau pom tias cov neeg laus muaj zog tiv thaiv kab mob uas lawv kis tau thaum menyuam yaus. Imprinting kuj tsis ntev los no tau pom los tiv thaiv tus kab mob khaub thuas avian tshiab subtypes ntawm tib pawg hemagglutinin phylogenetic (hemagglutinin, HA), raws li nrog thawj tus kab mob thaum yau.
Txog thaum tsis ntev los no, nqaim cross-tiv thaiv kev tiv thaiv tshwj xeeb rau ntau yam ntawm ib qho HA subtype tau suav tias yog hom tseem ceeb ntawm kev tiv thaiv kab mob khaub thuas raws caij nyoog. Txawm li cas los xij, muaj cov pov thawj tshiab qhia tias kev tsim ntawm kev tiv thaiv kuj tuaj yeem cuam tshuam los ntawm kev nco ntawm lwm yam kab mob khaub thuas antigens (piv txwv li, neuraminidase, NA). Txij li xyoo 1918, peb hom AN tau raug txheeb xyuas hauv tib neeg: H1, H2 thiab H3. Ntxiv mus, H1 thiab H2 yog nyob rau phylogenetic pawg 1, thiab H3 rau pawg 2.
Muab qhov tseeb tias kev luam ntawv feem ntau yuav ua rau muaj ntau yam kev hloov pauv hauv lub cev tiv thaiv kab mob, nws tuaj yeem xav tias cov kev hloov pauv no muaj qee yam hierarchy.
Cov kws tshawb fawb tau sau tseg tias txij li xyoo 1977, ob hom kab mob khaub thuas A-H1N1 thiab H3N2-tau kis raws caij nyoog ntawm cov pejxeem. Nyob rau tib lub sijhawm, qhov sib txawv ntawm cov pej xeem ntawm kev kis kab mob thiab cov tsos mob tau pom tseeb, tab sis kev kawm tsis zoo. Cov kev sib txawv no tej zaum yuav yog vim muaj kev cuam tshuam rau menyuam yaus: cov neeg laus yuav luag raug tus kab mob H1N1 raws li menyuam yaus (los ntawm 1918 txog 1975 nws tsuas yog tib hom kab mob hauv tib neeg). Yog li ntawd, cov neeg no tam sim no muaj kev tiv thaiv zoo dua los ntawm kev hloov pauv raws caij nyoog ntawm tus kab mob ntawm tus kab mob no. Ib yam li ntawd, ntawm cov tub ntxhais hluas, qhov muaj feem ntau tshaj plaws ntawm kev luam ntawv me nyuam yaus yog rau H3N2 tsis ntev los no (daim duab # 1), uas zoo ib yam nrog cov neeg mob tsawg ntawm cov neeg mob H3N2 hauv cov pej xeem no.
Duab No. 1: cov qauv sib txawv ntawm qhov kev cia siab ntawm kev tiv thaiv ntawm kev luam tawm thaum yau thiab qhov cuam tshuam ntawm tus kab mob evolution.
Ntawm qhov tod tes, qhov sib txawv no yuav cuam tshuam nrog kev hloov pauv ntawm tus kab mob subtypes lawv tus kheej. Yog li, H3N2 qhia tau sai dua drifting * nws antigenic phenotype dua H1N1.
Antigen drift * - Kev hloov pauv ntawm lub cev tiv thaiv kab mob ntawm cov kab mob.
Vim li no, H3N2 tuaj yeem ua tau zoo dua los tiv thaiv kev tiv thaiv yav dhau los hauv cov neeg laus uas muaj kev tiv thaiv kab mob tiv thaiv kab mob, thaum H1N1 yuav raug txwv tsis pub muaj kev cuam tshuam rau cov menyuam yaus uas tsis muaj kev tiv thaiv kab mob.
Txhawm rau kuaj txhua qhov kev xav tsis zoo, cov kws tshawb fawb tau txheeb xyuas cov ntaub ntawv kis kabmob los ntawm kev tsim cov haujlwm muaj feem cuam tshuam rau txhua qhov sib txawv ntawm cov qauv kev txheeb cais, uas tau muab piv nrog kev siv Akaike Information Criterion (AIC).
Ib qho kev soj ntsuam ntxiv kuj tau ua tiav ntawm qhov kev xav uas qhov sib txawv tsis yog vim kev luam tawm hauv kev hloov pauv ntawm cov kab mob.
Kev npaj kawm
Kev xav ua qauv siv cov ntaub ntawv los ntawm Arizona Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv (ADHS) ntawm 9510 tus neeg mob H1N1 thiab H3N2 thoob plaws lub xeev. Kwv yees li ntawm 76% ntawm cov ntaub ntawv tshaj tawm tau sau tseg hauv tsev kho mob thiab chaw kuaj mob, cov neeg mob ntxiv tsis tau teev tseg hauv chav kuaj. Nws kuj tseem paub tias kwv yees li ib nrab ntawm qhov chaw kuaj mob kuaj mob hnyav txaus ua rau muaj kev mus pw hauv tsev kho mob.
Cov ntaub ntawv siv hauv txoj kev tshawb fawb no suav nrog 22-xyoo lub sijhawm txij li xyoo 1993-1994 lub caij mob khaub thuas mus rau lub caij 2014-2015. Nws yog ib qho tsim nyog sau cia tias qhov piv txwv qhov loj me tau nce zuj zus tom qab xyoo 2009 muaj kev sib kis, yog li lub sijhawm no tsis suav nrog cov qauv (Table 1).
Table No. 1: Cov ntaub ntawv sib kis ntawm xyoo 1993 txog 2015 hais txog cov ntaub ntawv sau tseg ntawm tus kab mob H1N1 thiab H3N2.
Nws tseem yog ib qho tseem ceeb uas yuav tau xav txog tias txij li xyoo 2004, cov chaw soj ntsuam kev lag luam hauv Tebchaws Meskas tau xav kom xa tag nrho cov ntaub ntawv hais txog kev kis tus kabmob ntawm cov neeg mob mus rau tsoomfwv saib xyuas kev noj qab haus huv. Txawm li cas los xij, feem ntau ntawm cov ntaub ntawv txheeb xyuas (9150/9451) tau tshwm sim los ntawm lub caij 2004-2005, tom qab txoj cai tau pib siv.
Ntawm tag nrho 9510 tus neeg mob, 58 raug tshem tawm vim lawv yog cov neeg muaj xyoo yug ua ntej 1918 (lawv cov ntawv luam tawm tsis tuaj yeem txiav txim siab meej), thiab lwm 1 rooj plaub vim tias lub xyoo yug tsis raug. Yog li, 9541 kis tau suav nrog hauv cov qauv tshuaj ntsuam.
Nyob rau thawj theem ntawm kev ua qauv, qhov tshwm sim ntawm kev luam tawm rau cov kab mob H1N1, H2N2 lossis H3N2, tshwj xeeb rau xyoo yug, tau txiav txim siab. Cov kev tshwm sim no qhia txog tus qauv ntawm kev kis tus mob khaub thuas A hauv cov menyuam yaus thiab nws qhov kev nthuav dav los ntawm xyoo.
Cov neeg feem coob yug ntawm xyoo 1918 thiab 1957 tau kis tus kabmob thawj zaug nrog H1N1 subtype. Cov neeg yug ntawm xyoo 1957 thiab 1968 tau kis tus kabmob yuav luag txhua tus kabmob H2N2 subtype (1A). Thiab txij li xyoo 1968, qhov tseem ceeb ntawm tus kab mob no yog H3N2, uas tau dhau los ua tus kab mob ntawm feem coob ntawm cov neeg los ntawm pab pawg neeg hluas.
Txawm hais tias muaj qhov tshwm sim ntawm H3N2, H1N1 tseem tau nthuav tawm raws caij nyoog hauv cov pej xeem txij li xyoo 1977, ua rau muaj kev cuam tshuam ntawm cov neeg yug txij li nruab nrab-1970s (1A).
Yog tias imprinting ntawm AN subtypes qhia qhov yuav kis tau tus kab mob khaub thuas raws caij nyoog, ces kis tau rau H1 lossis H3 AN subtypes hauv cov menyuam yaus thaum yau yuav tsum muaj kev tiv thaiv mus ib txhis rau cov hloov tshiab tshiab ntawm tib AN subtypes. Yog tias kev tiv thaiv kev tiv thaiv ua haujlwm ntau dua rau qee yam ntawm NA (neuraminidase), ces kev tiv thaiv tas mus li yuav yog tus yam ntxwv ntawm N1 lossis N2 (1B).
Yog hais tias imprinting yog raws li dav NA, i.e. tiv thaiv ntau yam subtypes tshwm sim, tom qab ntawd cov tib neeg imprinted los ntawm H1 thiab H2 yuav tsum tau tiv thaiv los ntawm niaj hnub H1N1 raws caij nyoog. Nyob rau tib lub sijhawm, cov neeg uas sau rau H3 yuav raug tiv thaiv tsuas yog los ntawm cov caij nyoog niaj hnub H3N2 (1B).
Cov kws tshawb fawb sau tseg tias kev sib koom ua ke (hais lus, kev sib luag) ntawm kev kwv yees ntawm ntau yam imprinting qauv (1D-1I) yog kev zam tsis tau vim muaj kev txwv ntau haiv neeg ntawm cov kab mob khaub thuas antigenic subtypes circulating nyob rau hauv cov pej xeem nyob rau hauv lub xyoo pua dhau los.
Lub luag haujlwm tseem ceeb tshaj plaws hauv kev sib txawv ntawm kev luam tawm ntawm HA subtype, NA subtype lossis HA pab pawg qib yog ua los ntawm cov neeg muaj hnub nyoog nruab nrab uas thawj tus kab mob H2N2 (1B).
Txhua tus qauv kuaj tau siv cov kab sib xyaw ua ke ntawm cov hnub nyoog ntsig txog kab mob (1S), thiab kab mob txuam nrog xyoo yug (1D-1F), kom tau txais kev faib tawm ntawm H1N1 lossis H3N2 kis (1G - 1I).
Tag nrho ntawm 4 tus qauv tau tsim: qhov yooj yim tshaj plaws tsuas muaj qhov muaj hnub nyoog, thiab cov qauv nyuaj ntxiv cov qauv luam tawm ntawm qib HA subtype, ntawm qib NA subtype, lossis qib HA pawg.
Lub hnub nyoog zoo nkhaus muaj daim ntawv ntawm cov kauj ruam ua haujlwm uas tus txheeb ze ntawm kev pheej hmoo kis mob tau teem rau 1 hauv pawg hnub nyoog 0-4. Ntxiv rau pawg hnub nyoog tseem ceeb, kuj muaj cov hauv qab no: 5–10, 11–17, 18–24, 25–31, 32–38, 39–45, 46–52, 53–59, 60–66, 67–73, 74– 80, 81+ ib.
Hauv cov qauv uas suav nrog cov teebmeem imprinting, qhov feem pua ntawm cov tib neeg hauv txhua xyoo yug nrog kev tiv thaiv menyuam yaus yog suav tias yog qhov sib npaug rau qhov txo qis ntawm kev pheej hmoo kis mob.
Qhov tseem ceeb ntawm tus kab mob evolution kuj tau coj mus rau hauv tus account hauv kev ua qauv. Ua li no, peb siv cov ntaub ntawv uas tau piav qhia txog kev nce qib antigenic txhua xyoo, uas txhais tau tias yog qhov nruab nrab antigenic nrug ntawm cov kab mob ntawm cov kab mob tshwj xeeb (H1N1 ua ntej 2009, H1N1 tom qab 2009, thiab H3N2). "Antigenic nrug" ntawm ob hom kab mob khaub thuas yog siv los ua ib qho kev qhia ntawm qhov zoo sib xws hauv antigenic phenotype thiab muaj peev xwm tiv thaiv kab mob khaub thuas.
Txhawm rau ntsuas qhov cuam tshuam ntawm kev hloov pauv ntawm cov tshuaj tiv thaiv kab mob hauv lub hnub nyoog sib kis, kev hloov pauv ntawm cov neeg mob hauv cov menyuam yaus raug kuaj thaum lub caij uas muaj kev hloov pauv antigenic muaj zog.
Yog hais tias theem ntawm antigenic drift yog ib qho tseem ceeb ntawm cov hnub nyoog uas muaj feem yuav kis tau tus kab mob, qhov feem pua ntawm cov neeg mob soj ntsuam nyob rau hauv cov me nyuam yuav tsum tsis txhob cuam tshuam nrog txhua xyoo antigenic kev vam meej. Hauv lwm lo lus, hom kab mob uas tsis tau hloov pauv cov tshuaj tiv thaiv tseem ceeb los ntawm lub caij dhau los yuav tsum tsis muaj peev xwm dim ntawm kev tiv thaiv kab mob ua ntej hauv cov neeg laus uas muaj kev tiv thaiv kab mob. Cov kab mob zoo li no yuav muaj zog dua ntawm cov neeg uas tsis muaj kev tiv thaiv kab mob, uas yog, ntawm cov menyuam yaus.
Cov txiaj ntsig tshawb fawb
Kev tshuaj xyuas cov ntaub ntawv los ntawm lub xyoo tau pom tias H3N2 raws caij nyoog yog qhov ua rau kis tus kab mob ntawm cov neeg laus, thaum H1N1 cuam tshuam rau cov hnub nyoog nruab nrab thiab cov hluas (duab #2).
Duab No. 2: Kev faib cov kab mob H1N1 thiab H3N2 los ntawm hnub nyoog nyob rau lub sijhawm sib txawv.
Cov qauv no tau tshwm sim ob qho tib si hauv cov ntaub ntawv ua ntej xyoo 2009 muaj kev sib kis thiab tom qab nws.
Cov ntaub ntawv qhia tau hais tias imprinting ntawm NA subtype qib predominates tshaj imprinting ntawm HA subtype qib (ΔAIC = 34.54). Nyob rau tib lub sijhawm, muaj yuav luag tag tsis muaj kev luam tawm ntawm qib HA pawg (ΔAIC = 249.06), nrog rau qhov tsis tiav ntawm kev luam tawm (ΔAIC = 385.42).
Image # 3: Kev ntsuas qhov haum ntawm cov qauv rau cov ntaub ntawv tshawb fawb.
Kev ntsuam xyuas pom ntawm tus qauv haum (3C и 3D) tau lees paub tias cov qauv uas muaj cov kev cuam tshuam ntawm qhov nqaim ntawm NA lossis HA subtypes muab qhov zoo tshaj plaws haum rau cov ntaub ntawv siv hauv kev kawm. Qhov tseeb tias tus qauv uas tsis tuaj yeem luam tawm tsis tuaj yeem txhawb nqa los ntawm cov ntaub ntawv qhia tias imprinting yog qhov tseem ceeb ntawm kev txhim kho kev tiv thaiv kab mob hauv cov neeg laus hauv kev cuam tshuam rau cov kab mob khaub thuas raws caij nyoog. Txawm li cas los xij, imprinting ua haujlwm hauv qhov tshwj xeeb nqaim heev, uas yog, nws ua tshwj xeeb rau ntawm ib qho subtypes, thiab tsis yog nyob rau tag nrho cov kab mob khaub thuas subtypes.
Table No. 2: Kev ntsuas qhov haum ntawm cov qauv rau cov ntaub ntawv tshawb fawb.
Tom qab tswj hwm kev faib tawm hnub nyoog, qhov kwv yees muaj feem cuam tshuam txog hnub nyoog yog qhov siab tshaj plaws hauv cov menyuam yaus thiab cov neeg laus, zoo ib yam nrog kev sib sau ntawm lub cev tiv thaiv kab mob hauv cov menyuam yaus thiab tsis muaj zog tiv thaiv kab mob hauv cov neeg laus (ntawm 3A kwv yees nkhaus ntawm tus qauv zoo tshaj plaws yog qhia). Imprinting parameter kwv yees tsawg dua ib qho, qhia txog kev txo qis ntawm tus txheeb ze (Table 2). Hauv cov qauv zoo tshaj plaws, qhov kwv yees kwv yees qhov kev pheej hmoo txo qis los ntawm kev luam me nyuam yaus yog ntau dua rau H1N1 (0.34, 95% CI 0.29–0.42) dua li H3N2 (0.71, 95% CI 0.62–0.82).
Txhawm rau ntsuas qhov cuam tshuam ntawm tus kab mob kis rau lub hnub nyoog ntawm kev pheej hmoo kis tus kab mob, cov kws tshawb fawb tau nrhiav qhov txo qis ntawm kev kis tus kab mob ntawm cov menyuam yaus thaum lub sij hawm cuam tshuam nrog kev hloov pauv ntawm cov tshuaj antigenic, thaum cov kab mob uas muaj antigenic drift muaj txiaj ntsig zoo dua hauv kev kis kab mob rau cov neeg laus.
Cov ntaub ntawv tsom xam pom qhov tsis zoo me me tab sis tsis tseem ceeb hauv kev sib koom ua ke ntawm kev nce txhua xyoo hauv kev ua haujlwm antigenic thiab feem pua ntawm H3N2 kis tau pom hauv cov menyuam yaus (4A).
Duab No. 4: qhov cuam tshuam ntawm tus kab mob evolution ntawm lub hnub nyoog muaj feem cuam tshuam rau tus kab mob.
Txawm li cas los xij, tsis pom muaj kev sib raug zoo ntawm kev hloov pauv ntawm cov tshuaj tiv thaiv kab mob thiab qhov feem pua ntawm cov neeg mob pom hauv cov menyuam yaus hnub nyoog 10 xyoo thiab cov laus. Yog tias tus kab mob evolution tau ua lub luag haujlwm tseem ceeb hauv qhov kev faib tawm no, qhov tshwm sim yuav ua pov thawj pom tseeb ntawm kev hloov pauv ntawm cov neeg laus, tsis yog thaum piv cov neeg laus thiab cov menyuam yaus hnub nyoog qis dua 10 xyoo.
Ntxiv mus, yog tias qhov kev hloov pauv ntawm tus kab mob kis tau muaj feem cuam tshuam rau qhov sib txawv ntawm qhov sib txawv ntawm cov hnub nyoog sib kis, tom qab ntawd thaum H1N1 thiab H3N2 subtypes qhia qhov zoo sib xws ntawm kev sib kis txhua xyoo antigen, lawv lub hnub nyoog ntawm kev kis kab mob yuav tsum tshwm sim ntau dua.
Rau cov ncauj lus kom ntxaws ntxiv nrog cov nuances ntawm txoj kev tshawb no, kuv xav kom saib .
Epilogue
Hauv kev ua haujlwm no, cov kws tshawb fawb tau txheeb xyuas cov ntaub ntawv sib kis ntawm tus kabmob H1N1, H3N2 thiab H2N2. Cov ntaub ntawv tsom xam pom qhov kev sib raug zoo ntawm imprinting nyob rau hauv me nyuam yaus thiab kev pheej hmoo ntawm tus kab mob nyob rau hauv cov neeg laus. Hauv lwm lo lus, yog tias tus menyuam yaus hnub nyoog 50 xyoo tau kis tus kabmob H1N1 thiab tsis muaj H3N2, tom qab ntawd thaum muaj hnub nyoog laus qhov yuav kis tau tus kabmob H3N2 ntau dua li qhov yuav kis tau H1N1.
Lub ntsiab lus xaus ntawm txoj kev tshawb no yog tias nws yog ib qho tseem ceeb tsis tsuas yog dab tsi ib tug neeg raug kev txom nyem los ntawm thaum yau, tab sis kuj nyob rau hauv dab tsi txiav txim. Lub cim xeeb tiv thaiv kab mob, uas txhim kho thoob plaws lub neej, nquag "sau" cov ntaub ntawv los ntawm thawj kis kab mob, uas ua rau muaj txiaj ntsig zoo dua rau lawv thaum muaj hnub nyoog laus.
Cov kws tshawb fawb cia siab tias lawv txoj haujlwm yuav ua rau nws muaj peev xwm kwv yees tau zoo dua cov hnub nyoog twg uas muaj kev cuam tshuam ntau dua rau cov teebmeem ntawm cov kab mob khaub thuas. Qhov kev paub no tuaj yeem pab tiv thaiv kev sib kis, tshwj xeeb tshaj yog tias cov tshuaj tiv thaiv tsawg tsawg yuav tsum tau muab faib rau cov pej xeem.
Qhov kev tshawb fawb no tsis yog tsom mus nrhiav kev kho mob zoo rau txhua hom khaub thuas, txawm tias qhov ntawd yuav zoo heev. Nws yog tsom rau qhov uas muaj ntau yam tiag tiag thiab tseem ceeb nyob rau lub sijhawm no - tiv thaiv kev kis tus kabmob. Yog tias peb tsis tuaj yeem tshem tus kab mob tam sim ntawd, ces peb yuav tsum muaj tag nrho cov cuab yeej ua tau kom muaj nws. Ib qho kev ntseeg siab tshaj plaws ntawm ib qho kev sib kis yog tus cwj pwm tsis zoo rau nws ob qho tib si ntawm lub xeev feem ntau thiab txhua tus neeg tshwj xeeb. Panic, ntawm chav kawm, tsis yog qhov tsim nyog, vim tias nws tsuas tuaj yeem ua rau qhov tsis zoo, tab sis kev ceev faj tsis raug mob.
Ua tsaug rau kev nyeem ntawv, nyob xav paub, saib xyuas koj tus kheej thiab koj cov neeg koj hlub thiab muaj kev zoo siab rau hnub so! 🙂
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Ua tsaug uas koj tau nyob nrog peb. Koj puas nyiam peb cov ntawv? Xav pom cov ntsiab lus nthuav ntxiv? Txhawb nqa peb los ntawm kev tso ib qho kev txiav txim lossis qhia rau cov phooj ywg, , ib qho tshwj xeeb analogue ntawm nkag-theem servers, uas tau tsim los ntawm peb rau koj: (muaj nrog RAID1 thiab RAID10, mus txog 24 cores thiab mus txog 40GB DDR4).
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Tau qhov twg los: www.hab.com