Nyob rau lub caij ntuj sov xyoo 2018, lub tsev kawm ntawv lub caij ntuj sov txhua xyoo hauv bioinformatics tau muaj nyob ze ntawm St. Petersburg, qhov twg 100 undergraduate thiab kawm tiav cov tub ntxhais kawm tuaj kawm txog bioinformatics thiab kawm txog nws kev siv ntau yam ntawm biology thiab tshuaj.
Lub tsev kawm ntawv lub hom phiaj tseem ceeb yog kev tshawb fawb txog kev mob qog noj ntshav, tab sis muaj cov lus qhuab qhia ntawm lwm qhov chaw ntawm bioinformatics, xws li evolution mus rau kev soj ntsuam ntawm ib leeg-cell sequencing cov ntaub ntawv. Nyob rau lub lim tiam no, cov txiv neej tau kawm ua haujlwm nrog cov ntaub ntawv txuas ntxiv tom ntej, programmed hauv Python thiab R, siv cov cuab yeej bioinformatics thiab cov txheej txheem, tau paub txog cov txheej txheem ntawm cov txheej txheem biology, cov noob caj noob ces thiab cov qauv tshuaj thaum kawm cov qog, thiab ntau ntxiv.
Hauv qab no koj yuav pom cov vis dis aus ntawm 18 cov lus qhuab qhia hauv tsev kawm, nrog cov lus piav qhia luv luv thiab cov slides. Cov cim nrog lub hnub qub "*" yog qhov yooj yim heev thiab tuaj yeem saib yam tsis tau npaj ua ntej.
1*. Oncogenomics thiab tus kheej oncology | Mikhail Pyatnitsky, tshawb fawb lub koom haum ntawm Biomedical Chemistry
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Mikhail tau hais luv luv txog cov qog genomics thiab nkag siab txog kev hloov pauv ntawm cov qog nqaij hlav qog noj ntshav tso cai rau peb los daws cov teeb meem hauv oncology. Tus kws qhia ntawv tau them nyiaj tshwj xeeb rau kev piav qhia qhov sib txawv ntawm oncogenes thiab cov qog nqaij hlav, txoj hauv kev tshawb nrhiav "cov noob qog noj ntshav" thiab txheeb xyuas cov kab mob qog noj ntshav. Hauv kev xaus, Mikhail tau mloog zoo rau yav tom ntej ntawm oncogenomics thiab cov teeb meem uas yuav tshwm sim.
2*. Kev kuaj mob caj ces ntawm cov qog nqaij hlav qog nqaij hlav | Andrey Afanasyev, yRisk
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Andrey tau hais txog cov kab mob qog nqaij hlav thiab tshuaj xyuas lawv cov kab mob biology, kab mob sib kis thiab kev kho mob tshwm sim. Ib feem ntawm cov lus qhuab qhia yog mob siab rau qhov teeb meem ntawm kev ntsuam xyuas caj ces - leej twg yuav tsum tau ua nws, ua li cas rau qhov no, qhov teeb meem tshwm sim hauv kev ua cov ntaub ntawv thiab txhais cov txiaj ntsig, thiab, thaum kawg, cov txiaj ntsig zoo li cas rau cov neeg mob thiab lawv cov txheeb ze. .
3*. Pan-Cancer Atlas | German Demidov, BIST/UPF
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Txawm hais tias ntau xyoo ntawm kev tshawb fawb hauv thaj tsam ntawm cov kab mob qog noj ntshav thiab epigenomics, cov lus teb rau lo lus nug "yuav ua li cas, qhov twg thiab vim li cas cov qog nqaij hlav tshwm sim" tseem tsis tiav. Ib qho laj thawj rau qhov no yog qhov yuav tsum tau ua kom tau raws li cov qauv kev xav tau thiab kev ua tiav ntawm cov ntaub ntawv loj heev txhawm rau txhawm rau txheeb xyuas qhov cuam tshuam ntawm qhov loj me uas nyuaj rau kev txheeb xyuas hauv cov ntaub ntawv txwv (qhov loj me uas yog qhov zoo rau kev kawm hauv ib lossis ntau lub chaw soj nstuam) , tab sis uas nyob rau hauv lub aggregate plays lub luag hauj lwm tseem ceeb lub luag hauj lwm loj nyob rau hauv xws li ib tug complex thiab multifactorial kab mob xws li mob cancer.
Ob peb xyoos dhau los, ntau lub ntiaj teb cov pab pawg tshawb fawb muaj zog tshaj plaws, paub txog qhov teeb meem no, tau pib koom nrog hauv kev sim nrhiav thiab piav qhia tag nrho cov teebmeem no. Herman tau hais txog ib qho ntawm cov kev pib no (Lub PanCancer Atlas) thiab cov txiaj ntsig tau los ua ib feem ntawm kev ua haujlwm ntawm lub koom haum ntawm lub chaw soj nstuam no thiab luam tawm hauv ib qho tshwj xeeb ntawm Cell hauv cov lus qhuab qhia no.
4. Chip-Seq nyob rau hauv txoj kev tshawb no ntawm epigenetic mechanisms | Oleg Shpynov, JetBrains Tshawb Fawb
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Txoj cai ntawm cov noob qhia yog ua nyob rau hauv ntau txoj kev. Ntawm nws cov lus qhuab qhia, Oleg tau hais txog kev tswj hwm epigenetic los ntawm kev hloov kho histone, kev kawm txog cov txheej txheem no siv cov txheej txheem ChiP-seq thiab cov txheej txheem rau kev tshuaj xyuas cov txiaj ntsig tau txais.
5. Multiomics hauv Cancer Research | Konstantin Okonechnikov, German Cancer Research Center
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Txoj kev loj hlob ntawm kev sim technologies nyob rau hauv molecular biology tau ua rau nws muaj peev xwm mus ua ke txoj kev kawm ntawm ib tug ntau yam ntawm functional txheej txheem nyob rau hauv lub hlwb, lub cev los yog tag nrho cov kab mob. Txhawm rau tsim kom muaj kev sib txuas ntawm cov khoom ntawm cov txheej txheem lom neeg, nws yog ib qho tsim nyog yuav tsum siv multiomics, uas sib txuas cov ntaub ntawv sim loj los ntawm genomics, transcriptomics, epigenomics thiab proteomics. Konstantin tau muab cov piv txwv meej ntawm kev siv ntau yam omics hauv kev tshawb fawb txog mob qog noj ntshav nrog rau kev tsom mus rau menyuam yaus oncology.
6. Versatility thiab txwv ntawm Tib Cell Kev Ntsuam Xyuas | Konstantin Okonechnikov
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Cov lus qhia ntxaws ntxiv ntawm ib leeg-cell RNA-seq thiab cov txheej txheem rau kev tshuaj xyuas cov ntaub ntawv no, nrog rau txoj hauv kev los daws cov teeb meem pom tseeb thiab zais thaum kawm lawv.
7. Kev soj ntsuam ntawm ib leeg-cell RNA-seq cov ntaub ntawv | Konstantin Zaitsev, Washington University hauv St
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Introductory lus qhuab qhia ntawm ib leeg cell sequencing. Konstantin tham txog cov txheej txheem ua ntu zus, nyuaj hauv kev ua haujlwm hauv chav kuaj thiab tshuaj xyuas bioinformatics, thiab txoj hauv kev los kov yeej lawv.
8. Kev kuaj mob ntawm cov leeg nqaij dystrophy siv nanopore sequencing | Pavel Avdeev, George Washington University
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Sequenceing siv Oxford Nanopore thev naus laus zis muaj qhov zoo uas tuaj yeem siv los txheeb xyuas cov caj ces ntawm cov kab mob xws li cov leeg nqaij dystrophy. Hauv nws cov lus qhuab qhia, Pavel tau hais txog kev tsim lub raj xa dej rau kev kuaj mob tus kab mob no.
9*. Daim duab sawv cev ntawm genome | Ilya Minkin, Pennsylvania State University
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Cov qauv duab tso cai rau cov neeg sawv cev ntawm ntau qhov sib xws thiab feem ntau siv hauv genomics. Ilya tau hais meej txog yuav ua li cas genomic sequences reconstructed siv graphs, yuav ua li cas thiab yog vim li cas lub de Bruin graph yog siv, npaum li cas ib tug "graph" mus kom ze ua rau kom qhov tseeb ntawm kev hloov pauv, thiab dab tsi daws teeb meem nrog kev siv graphs tseem nyob.
10*. Lom zem proteomics | Pavel Sinitsyn, Max Planck lub koom haum ntawm Biochemistry (2 ntu)
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Proteins yog lub luag haujlwm rau feem ntau cov txheej txheem biochemical hauv cov kab mob uas muaj sia nyob, thiab txog tam sim no proteomics yog tib txoj hauv kev rau kev soj ntsuam thoob ntiaj teb ntawm lub xeev ntawm ntau txhiab tus proteins ib txhij. Qhov ntau ntawm cov teeb meem daws tau zoo heev - los ntawm kev txheeb xyuas cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv kab mob kom txiav txim siab qhov chaw ntawm ntau txhiab cov proteins. Hauv nws cov lus qhuab qhia, Pavel tau hais txog cov no thiab lwm yam kev siv ntawm proteomics, nws txoj kev loj hlob tam sim no thiab qhov teeb meem hauv kev txheeb xyuas cov ntaub ntawv.
kaum ib*. Cov hauv paus ntsiab lus ntawm molecular simulations | Pavel Yakovlev, BIOCAD
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Introductory theoretical lecture on molecular dynamics: vim li cas nws thiaj li xav tau, nws ua li cas thiab nws siv li cas hauv kev cuam tshuam rau kev tsim tshuaj. Pavel tau mloog zoo rau cov txheej txheem ntawm molecular dynamics, kev piav qhia ntawm molecular rog, kev piav qhia ntawm kev sib txuas, cov ntsiab lus ntawm "kev quab yuam" thiab "kev koom ua ke", kev txwv hauv kev ua qauv, thiab ntau ntxiv.
12* ib. Molecular Biology thiab Genetics | Yuri Barbitov, lub koom haum ntawm Bioinformatics
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Ib qho kev qhia peb feem rau molecular biology thiab noob caj noob ces rau engineering cov tub ntxhais kawm thiab cov kawm tiav. Thawj qhov kev qhuab qhia tham txog cov ntsiab lus ntawm cov biology niaj hnub no, cov teeb meem ntawm cov qauv genome thiab qhov tshwm sim ntawm kev hloov pauv. Qhov thib ob suav nrog kev nthuav dav txog cov teeb meem ntawm cov noob ua haujlwm, cov txheej txheem ntawm kev hloov pauv thiab kev txhais lus, qhov thib peb suav nrog kev tswj hwm ntawm cov noob caj noob ces thiab cov txheej txheem molecular biological.
13* ib. Cov ntsiab lus ntawm NGS Cov Ntaub Ntawv Kev Ntsuam Xyuas | Yuri Barbitov, lub koom haum ntawm Bioinformatics
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Cov lus qhuab qhia piav qhia txog cov txheej txheem thib ob tiam (NGS), lawv hom thiab cov yam ntxwv. Tus kws qhia ntawv piav qhia meej txog yuav ua li cas cov ntaub ntawv "tso tawm" los ntawm cov kab ke sib txuas, nws hloov pauv li cas rau kev tshuaj xyuas, thiab dab tsi yog txoj hauv kev ua haujlwm nrog nws.
14* ib. Siv cov kab hais kom ua, xyaum | Gennady Zakharov, EPAM
Kev pom zoo ntawm Linux cov lus txib kab lus txib, kev xaiv thiab cov hauv paus ntawm kev siv lawv. Cov piv txwv tsom mus rau kev tsom xam ntawm cov txheej txheem DNA ua ntu zus. Ntxiv rau cov txheej txheem Linux ua haujlwm (piv txwv li, miv, grep, sed, awk), cov khoom siv rau kev ua haujlwm nrog cov kab ke (samtools, bedtools) raug txiav txim siab.
15* ib. Cov ntaub ntawv visualization rau me me | Nikita Alekseev, ITMO University
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Txhua tus neeg tau muaj kev paub dhau los ntawm kev nthuav qhia cov txiaj ntsig ntawm lawv tus kheej cov haujlwm tshawb fawb lossis nkag siab lwm tus neeg cov duab kos duab, duab kos duab thiab duab. Nikita qhia yuav ua li cas txhais cov duab thiab cov duab kom raug, qhia qhov tseem ceeb ntawm lawv; yuav ua li cas kos duab meej. Tus kws qhia ntawv tseem hais txog qhov yuav tsum tau nrhiav thaum nyeem ib tsab xov xwm lossis saib kev lag luam.
16* ib. Cov hauj lwm hauv Bioinformatics | Victoria Korzhova, Max Planck lub koom haum ntawm Biochemistry
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Victoria tau hais txog cov qauv ntawm kev kawm txuj ci txawv teb chaws thiab qhov koj yuav tsum tau ua tib zoo saib xyuas txhawm rau tsim kom muaj kev ua haujlwm hauv kev tshawb fawb lossis kev lag luam raws li kev kawm tiav, kawm tiav lossis kawm tiav.
17* ib. Yuav sau CV li cas rau tus kws tshawb fawb | Victoria Korzhova, Max Planck lub koom haum ntawm Biochemistry
Dab tsi tawm hauv CV thiab dab tsi yuav tshem tawm? Dab tsi yog qhov tseeb yuav txaus siab rau tus thawj tswj hwm lub peev xwm, thiab qhov twg zoo dua tsis hais? Koj yuav tsum npaj cov ntaub ntawv li cas los ua kom koj qhov resume sawv tawm? Cov lus qhuab qhia yuav muab cov lus teb rau cov lus nug no thiab lwm yam.
18* ib. Kev lag luam bioinformatics ua haujlwm li cas | Andrey Afanasyev, yRisk
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Kev ua lag luam ua haujlwm li cas thiab qhov twg tuaj yeem ua haujlwm rau bioinformatician? Cov lus teb rau lo lus nug no yog nthuav dav, nrog rau cov piv txwv thiab cov lus qhia, hauv Andrey cov lus qhuab qhia.
Qhov kawg
Raws li koj tuaj yeem pom, cov lus qhuab qhia hauv tsev kawm yog qhov dav dav hauv cov ncauj lus - los ntawm cov qauv molecular thiab kev siv cov duab kos rau genome los ua ke, mus rau kev tsom xam ntawm ib lub hlwb thiab tsim txoj haujlwm tshawb fawb. Peb ntawm Lub Tsev Kawm Ntawv ntawm Bioinformatics sim suav nrog ntau lub ncauj lus hauv tsev kawm ntawv txoj haujlwm txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm
Lub tsev kawm ntawv tom ntej hauv bioinformatics yuav muaj thaum Lub Xya Hli 29 txog Lub Yim Hli 3, 2019 nyob ze Moscow. . Lub ntsiab lus xyoo no yuav yog bioinformatics hauv kev loj hlob biology thiab kev tshawb fawb kev laus.
Rau cov neeg uas xav kawm txog bioinformatics hauv qhov tob, peb tseem txais cov ntawv thov rau peb hauv St. Petersburg. Los yog ua raws li peb cov xov xwm hais txog kev qhib qhov program hauv Moscow lub caij nplooj zeeg no.
Rau cov neeg uas tsis nyob rau hauv St. Petersburg los yog Moscow, tab sis tiag tiag xav los ua ib tug bioinformatician, peb tau npaj hauv algorithms, programming, noob caj noob ces thiab biology.
Peb kuj muaj kaum ob , uas koj tuaj yeem pib mus dhau tam sim no.
Xyoo 2018, lub tsev kawm ntawv lub caij ntuj sov hauv bioinformatics tau tuav nrog kev txhawb nqa ntawm peb cov neeg koom tes niaj hnub - cov tuam txhab JetBrains, BIOCAD thiab EPAM, uas peb ua tsaug rau lawv ntau heev.
Bioinformatics txhua tus!
PS Yog tias koj tsis xav tias nws txaus, ΠΈ .
Tau qhov twg los: www.hab.com