M'chilimwe cha 2018, sukulu yachilimwe yapachaka ya bioinformatics inachitikira pafupi ndi St.
Cholinga chachikulu cha sukuluyi chinali pa kafukufuku wa khansa, koma panali zokambidwa pazambiri zina za bioinformatics, kuyambira ku chisinthiko mpaka kusanthula deta yotsatizana ya cell imodzi. Pakupita kwa sabata, anyamatawo adaphunzira kugwira ntchito ndi deta yotsatizana ya m'badwo wotsatira, wokonzedwa mu Python ndi R, adagwiritsa ntchito zipangizo zamakono ndi machitidwe a bioinformatics, adadziwa bwino njira za biology, chibadwa cha anthu ndi kuyerekezera mankhwala pophunzira zotupa, ndi zina zambiri.
Pansipa mudzapeza vidiyo ya nkhani 18 zokambidwa pasukulupo, zofotokoza mwachidule ndi zithunzi. Zolembedwa ndi nyenyezi "*" ndizofunika kwambiri ndipo zimatha kuwonedwa osakonzekeratu.
1*. Oncogenomics ndi oncology payekha | Mikhail Pyatnitsky, Research Institute of Biomedical Chemistry
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Mikhail adalankhula mwachidule za chotupa genomics ndi momwe kumvetsetsa kusinthika kwa maselo a khansa kumatithandizira kuthana ndi zovuta za oncology. Mphunzitsiyo adapereka chidwi kwambiri pofotokozera kusiyana pakati pa oncogenes ndi zotupa zotupa zotupa, njira zofufuzira "majini a khansa" ndikuzindikira ma cell a zotupa. Pomaliza, Mikhail anasamala za tsogolo la oncogenomics ndi mavuto omwe angabwere.
2*. Kuzindikira kwa majini a chotupa chobadwa nacho | Andrey Afanasyev, yRisk
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Andrey adalankhula za ma syndromes obadwa nawo ndipo adakambirana za biology, miliri ndi mawonetseredwe azachipatala. Gawo la phunziroli limaperekedwa pa nkhani ya kuyesa kwa majini - omwe akuyenera kukumana nawo, zomwe zimachitidwa pa izi, ndi zovuta zotani zomwe zimabwera pokonza deta ndi kutanthauzira zotsatira, ndipo, potsiriza, zimabweretsa phindu lanji kwa odwala ndi achibale awo. .
3*. The Pan-Cancer Atlas | German Demidov, BIST/UPF
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Ngakhale zaka makumi ambiri zafukufuku pa nkhani ya khansa ya genomics ndi epigenomics, yankho la funso lakuti "motani, kuti ndi chifukwa chiyani ma syndromes otupa amachokera" akadali osakwanira. Chifukwa chimodzi cha izi ndi kufunikira kwa kupeza kovomerezeka ndi kukonza deta yochuluka kwambiri kuti muwone zotsatira za kukula kwazing'ono zomwe zimakhala zovuta kuzizindikira mu seti ya data yochepa (kukula kwake komwe kumafanana ndi kafukufuku mkati mwa labotale imodzi kapena zingapo) , koma omwe ali pagulu amatenga gawo lalikulu pamavuto ovuta komanso osiyanasiyana monga khansa.
M'zaka zingapo zapitazi, magulu ambiri ofufuza amphamvu kwambiri padziko lonse lapansi, akudziwa za vutoli, ayamba kugwirizana kuti azindikire ndi kufotokoza zotsatira zonsezi. Herman analankhula za imodzi mwazinthuzi (The PanCancer Atlas) ndi zotsatira zomwe zinapezedwa ngati gawo la ntchito ya ma laboratories awa ndikufalitsidwa munkhani yapadera ya Cell munkhani iyi.
4. ChIP-Seq pophunzira njira za epigenetic | Oleg Shpynov, JetBrains Research
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Kuwongolera mayendedwe a jini kumachitika m'njira zosiyanasiyana. Pankhani yake, Oleg analankhula za malamulo a epigenetic kupyolera mu kusintha kwa histone, kufufuza njirazi pogwiritsa ntchito njira ya ChIP-seq ndi njira zowunikira zotsatira zomwe zapezedwa.
5. Multiomics mu Kafukufuku wa Khansa | Konstantin Okonechnikov, Germany Cancer Research Center
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Kupanga matekinoloje oyesera mu biology ya mamolekyulu kwapangitsa kuti zitheke kuphatikiza kafukufuku wamitundu ingapo yogwira ntchito m'maselo, ziwalo kapena ngakhale chamoyo chonse. Kukhazikitsa kugwirizana pakati pa zigawo zikuluzikulu za njira zamoyo, m'pofunika kugwiritsa ntchito ma multiomics, omwe amaphatikiza deta yaikulu yoyesera kuchokera ku genomics, transcriptomics, epigenomics ndi proteomics. Konstantin anapereka zitsanzo zomveka bwino za kugwiritsa ntchito ma multi-omics pa kafukufuku wa khansa poyang'ana pa oncology ya ana.
6. Kusinthasintha ndi Zochepera pa Kusanthula Kwa Cell Limodzi | Konstantin Okonechnikov
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Nkhani yowonjezereka ya selo imodzi ya RNA-seq ndi njira zowunikira deta iyi, komanso njira zothetsera mavuto oonekera komanso obisika pophunzira.
7. Kusanthula deta imodzi ya RNA-seq | Konstantin Zaitsev, yunivesite ya Washington ku St
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Chiyambi cha kutsatizana kwa selo imodzi. Konstantin akukambirana njira zotsatirira, zovuta pazantchito za labotale ndi kusanthula kwa bioinformatics, ndi njira zothana nazo.
8. Kuzindikira kwa muscular dystrophy pogwiritsa ntchito nanopore sequencing | Pavel Avdeev, George Washington University
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Kutsatizana pogwiritsa ntchito ukadaulo wa Oxford Nanopore kuli ndi zabwino zomwe zingagwiritsidwe ntchito kuzindikira zomwe zimayambitsa matenda monga muscular dystrophy. Mβnkhani yake, Pavel analankhula za kakulidwe ka payipi yodziwira matenda.
9* pa. Chiwonetsero cha ma graph a genome | Ilya Minkin, Pennsylvania State University
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Zitsanzo za ma graph zimalola kuyimira kophatikizika kwa kuchuluka kwamayendedwe ofanana ndipo nthawi zambiri amagwiritsidwa ntchito mu genomics. Ilya analankhula mwatsatanetsatane za momwe ma genomic amamangidwiranso pogwiritsa ntchito ma graph, momwe ndi chifukwa chake graph ya de Bruin imagwiritsiridwa ntchito, kuchuluka kwa njira ya "graph" yotereyi kumawonjezera kulondola kwa kusaka kwa masinthidwe, ndi zovuta zotani zomwe sizinathetsedwe pogwiritsa ntchito ma graph akadali.
10*. Zosangalatsa za proteinomics | Pavel Sinitsyn, Max Planck Institute of Biochemistry (magawo awiri)
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Mapuloteni ndi omwe amachititsa kuti zinthu zambiri zamoyo zikhalepo m'zamoyo, ndipo mpaka pano ma proteomics ndiyo njira yokhayo yowunikira dziko lonse lapansi pazochitika zamapuloteni masauzande ambiri panthawi imodzi. Mavuto osiyanasiyana omwe amathetsedwa ndi ochititsa chidwi - kuyambira pakuzindikira ma antibodies ndi ma antigen mpaka kudziwa komwe kuli mapuloteni masauzande angapo. M'maphunziro ake, Pavel adalankhula za izi ndi ntchito zina za proteinomics, chitukuko chake chapano komanso zovuta pakusanthula deta.
khumi ndi chimodzi*. Mfundo zoyambira zoyeserera zama cell | Pavel Yakovlev, BIOCAD
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Nkhani yoyambilira yazambiri zama cell: chifukwa chake ikufunika, zomwe imachita komanso momwe imagwiritsidwira ntchito pokhudzana ndi chitukuko cha mankhwala. Pavel anatchera khutu ku njira zama cell dynamics, kufotokozera mphamvu za mamolekyulu, kufotokozera kwa kugwirizana, malingaliro a "force field" ndi "integration", zoperewera pakujambula, ndi zina zambiri.
12*. Molecular Biology ndi Genetics | Yuri Barbitov, Institute of Bioinformatics
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Chiyambi cha magawo atatu a biology ya mamolekyulu ndi ma genetics kwa ophunzira a engineering ndi omaliza maphunziro. Nkhani yoyamba ikufotokoza mfundo za biology yamakono, nkhani za kamangidwe ka ma genome komanso kupezeka kwa masinthidwe. Yachiwiri ikufotokoza mwatsatanetsatane nkhani za momwe majini amagwirira ntchito, njira zolembera ndi kumasulira, yachitatu ikukhudzana ndi kuwongolera kafotokozedwe ka majini ndi njira zoyambira zamoyo zamagulu.
13*. Mfundo za NGS Data Analysis | Yuri Barbitov, Institute of Bioinformatics
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Nkhaniyi ikufotokoza njira zotsatizana za m'badwo wachiwiri (NGS), mitundu yawo ndi mawonekedwe awo. Mphunzitsi akufotokoza mwatsatanetsatane momwe deta "zotuluka" kuchokera ku sequencer zimapangidwira, momwe zimasinthidwira kuti zifufuzidwe, ndi njira zotani zogwirira ntchito.
14*. Pogwiritsa ntchito mzere wolamula, yesani | Gennady Zakharov, EPAM
Chidule cha malamulo othandiza a Linux, zosankha ndi zoyambira zogwiritsira ntchito. Zitsanzo zimayang'ana pa kusanthula kwa DNA yotsatizana. Kuphatikiza pa magwiridwe antchito a Linux (mwachitsanzo, mphaka, grep, sed, awk), zida zogwirira ntchito motsatizana (samtools, zida zogona) zimaganiziridwa.
15*. Kuwona kwa data kwa ang'ono | Nikita Alekseev, Yunivesite ya ITMO
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Aliyense wakhala ndi chidziwitso chowonetsera zotsatira za ntchito zawo za sayansi kapena kumvetsetsa zojambula za anthu ena, ma grafu ndi zithunzi. Nikita adafotokozera momwe angatanthauzire molondola ma graph ndi zithunzi, ndikuwunikira chinthu chachikulu kwa iwo; kujambula zithunzi zomveka bwino. Mphunzitsiyo adatsindikanso zomwe muyenera kuyang'ana powerenga nkhani kapena kuwonera malonda.
16*. Ntchito mu Bioinformatics | Victoria Korzhova, Max Planck Institute of Biochemistry
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Victoria adalankhula za kapangidwe ka sayansi yamaphunziro kumayiko ena komanso zomwe muyenera kuziganizira kuti mupange ntchito yasayansi kapena yamakampani ngati undergraduate, omaliza maphunziro kapena omaliza maphunziro.
17*. Momwe mungalembe CV kwa wasayansi | Victoria Korzhova, Max Planck Institute of Biochemistry
Zoyenera kusiya mu CV ndi zomwe mungachotse? Ndi mfundo ziti zomwe zingasangalatse woyang'anira labu, ndi zomwe zili bwino osatchula? Kodi muyenera kukonza bwanji zambiri kuti pitilizani kuwonetseke? Nkhaniyi idzayankha mafunso awa ndi ena.
18*. Momwe msika wa bioinformatics umagwirira ntchito | Andrey Afanasyev, yRisk
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Kodi msika umagwira ntchito bwanji ndipo katswiri wa bioinformatics angagwire ntchito kuti? Yankho la funso ili likuperekedwa mwatsatanetsatane, ndi zitsanzo ndi malangizo, mu nkhani Andrey.
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Monga momwe mwawonera, maphunziro a pasukulupo amakhala otakataka pamitu - kuyambira kutengera mamolekyulu ndi kugwiritsa ntchito ma graph pophatikiza ma genome, kusanthula kwa maselo amodzi ndikumanga ntchito yasayansi. Ife ku Institute of Bioinformatics timayesa kuphatikiza mitu yosiyanasiyana mu pulogalamu ya sukuluyi kuti tikwaniritse maphunziro ambiri a bioinformatics momwe tingathere, komanso kuti wophunzira aliyense aphunzire china chatsopano komanso chothandiza.
Sukulu yotsatira ya bioinformatics idzachitika kuyambira pa July 29 mpaka August 3, 2019 pafupi ndi Moscow. . Mutu wa chaka chino ukhala bioinformatics mu chitukuko cha biology ndi kafukufuku wokalamba.
Kwa iwo omwe akufuna kuphunzira za bioinformatics mozama, tikuvomerabe zofunsira zathu ku St. Petersburg. Kapena tsatirani nkhani zathu za kutsegulidwa kwa pulogalamuyi ku Moscow kugwa uku.
Kwa iwo omwe sali ku St. Petersburg kapena Moscow, koma akufunadi kukhala bioinformatics, takonzekera mu ma algorithms, mapulogalamu, genetics ndi biology.
Tilinso ndi ambiri , zomwe mungayambe kudutsa pakali pano.
Mu 2018, sukulu ya chilimwe mu bioinformatics inachitika mothandizidwa ndi abwenzi athu nthawi zonse - makampani JetBrains, BIOCAD ndi EPAM, omwe timawathokoza kwambiri.
Bioinformatics aliyense!
PS Ngati simunaganize kuti ndizokwanira, ΠΈ .
Source: www.habr.com