{"id":39037,"date":"2019-10-31T22:27:31","date_gmt":"2019-10-31T19:27:31","guid":{"rendered":"https:\/\/prohoster.info\/blog\/kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost\/"},"modified":"2019-10-31T22:27:31","modified_gmt":"2019-10-31T19:27:31","slug":"kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost","status":"publish","type":"post","link":"https:\/\/prohoster.info\/ro\/blog\/news\/kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost","title":{"rendered":"Cartea \u00abMitocondria egoist\u0103. Cum s\u0103 ne p\u0103str\u0103m s\u0103n\u0103tatea \u0219i s\u0103 am\u00e2n\u0103m \u00eemb\u0103tr\u00e2nirea\u00bb","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><noindex><a rel=\"nofollow\" href=\"https:\/\/habr.com\/ru\/company\/piter\/blog\/471704\/\"><img decoding=\"async\" alt=\"Cartea \u00abMitocondria egoist\u0103. Cum s\u0103 ne p\u0103str\u0103m s\u0103n\u0103tatea \u0219i s\u0103 am\u00e2n\u0103m \u00eemb\u0103tr\u00e2nirea\u00bb\" src=\"\/wp-content\/uploads\/2019\/10\/d320068deaa5cc852485a11db0f87917.jpg\" style=\"display:block;margin: 0 auto;\" \/><\/a><\/noindex> Visul oric\u0103rei persoane este s\u0103 r\u0103m\u00e2n\u0103 t\u00e2n\u0103r c\u00e2t mai mult posibil. Nu vrem s\u0103 \u00eemb\u0103tr\u00e2nim \u0219i s\u0103 ne \u00eemboln\u0103vim, ne temem de tot \u2014 cancer, boala Alzheimer, infarct, accident vascular cerebral\u2026 E timpul s\u0103 \u00een\u021belegem de unde provine cancerul, dac\u0103 exist\u0103 o leg\u0103tur\u0103 \u00eentre insuficien\u021ba cardiac\u0103 \u0219i boala Alzheimer, infertilitate \u0219i pierderea auzului. De ce uneori suplimentele cu antioxidan\u021bi aduc mai multe prejudicii dec\u00e2t beneficii? \u0218i, cel mai important: putem tr\u0103i mult \u0219i f\u0103r\u0103 boli, iar dac\u0103 da, cum?<\/p>\n<p>\u00cen organismul nostru func\u021bioneaz\u0103 mici \u201esta\u021bii energetice\u201d \u2014 mitocondriile. Acestea sunt responsabile pentru s\u0103n\u0103tatea \u0219i starea noastr\u0103 de bine. Atunci c\u00e2nd func\u021bioneaz\u0103 bine, nu sim\u021bim lipsa de energie. Iar c\u00e2nd func\u021bioneaz\u0103 prost \u2014 suferim de boli. Doctorul Li Niu dezv\u0103luie un secret: bolile care par a fi ne\u00eenrudite la prima vedere \u2014 diabetul, cancerul, schizofrenia, oboseala cronic\u0103, boala Parkinson \u0219i altele \u2014 au o natur\u0103 comun\u0103.<\/p>\n<p>Ast\u0103zi \u0219tim cum s\u0103 \u00eembun\u0103t\u0103\u021bim func\u021bionarea mitocondriilor, care asigur\u0103 organismul cu 90% din energie. \u00cen aceast\u0103 carte v\u0103 a\u0219teapt\u0103 informa\u021bii actuale despre nutri\u021bie, stil de via\u021b\u0103, dieta ketogenic\u0103 \u0219i suplimentele care restabilesc s\u0103n\u0103tatea mitocondriilor, \u0219i prin urmare, a noastr\u0103.<br \/>\n<noindex><a rel=\"nofollow\" name=\"habracut\"><\/a><\/noindex><\/p>\n<h3>Fragment. Sindromul mitocondrial<\/h3>\n<p>\n\u00cemi este ru\u0219ine s\u0103 recunosc, dar am fost spectator la emisiunea de tip reality \u00abMireas\u0103 pentru fiul meu\u00bb. M-a impresionat foarte mult episodul trei din sezonul 17 (ianuarie 2013), \u00een care Sin (mirele) \u0219i Ashley (candidata) au mers la o \u00eent\u00e2lnire cu dou\u0103 fete care sufereau de boli mitocondriale. Pentru mul\u021bi dintre voi, dac\u0103 a\u021bi urm\u0103rit episodul, a fost prima \u00eent\u00e2lnire cu sindromul mitocondrial (sindromul mitocondrial este un complex de boli legate de leziuni congenitale ale mitocondriilor). Totu\u0219i, acest grup de boli este studiat din ce \u00een ce mai calitativ pe m\u0103sur\u0103 ce tehnologiile de testare genetic\u0103 \u0219i secven\u021biere genetic\u0103 devin mai simple, mai ieftine \u0219i mai accesibile. <\/p>\n<p>P\u00e2n\u0103 la \u00eenceputul anilor '80, c\u00e2nd genomul mitocondrial uman a fost complet secven\u021biat, raportarea bolilor mitocondriale era rar\u0103. Situa\u021bia s-a schimbat odat\u0103 cu ob\u021binerea capacit\u0103\u021bii de a decoda ADN-ul mitocondrial al multor pacien\u021bi. Aceasta a dus la o cre\u0219tere semnificativ\u0103 a num\u0103rului de pacien\u021bi \u00eenregistra\u021bi care sufer\u0103 de boli mitocondriale ereditare. Printre ace\u0219tia se num\u0103r\u0103 aproximativ unul din cinci (sau chiar doi din dou\u0103zeci \u0219i cinci) mii de oameni. Aici nu lu\u0103m \u00een considerare persoanele cu forme neexprimate ale bolilor mitocondriale. \u00cen plus, a crescut \u0219i lista simptomelor sindromului mitocondrial, ceea ce dovede\u0219te natura haotic\u0103 a acestor boli. <\/p>\n<p>Bolile mitocondriale se caracterizeaz\u0103 prin imagini genetice \u0219i clinice extrem de complexe, reprezent\u00e2nd un amestec dintr-un spectru foarte larg de categorii diagnostice existente. Modelele de mo\u0219tenire aici, uneori, urmeaz\u0103 iar alteori nu urmeaz\u0103 legile lui Mendel. Mendel a descris regularit\u0103\u021bile mo\u0219tenirii caracteristicilor prin genele normale ale ADN-ului nuclear. Probabilitatea de apari\u021bie a unei tr\u0103s\u0103turi genetice sau a unei boli ereditare poate fi u\u0219or calculat\u0103 pe baza prognozei cantitative a rezultatelor diviziunii descenden\u021bei pe diferite tr\u0103s\u0103turi calitative prin mo\u0219tenirea aleatorie a uneia dintre cele dou\u0103 copii ale aceluia\u0219i gen de la fiecare dintre p\u0103rin\u021bi (\u00een urma c\u0103reia fiecare descendent prime\u0219te dou\u0103 copii ale fiec\u0103rui gen). \u00cen cazurile \u00een care sindromul mitocondrial este cauzat de un defect \u00een genele nucleare, modelele de mo\u0219tenire corespunz\u0103toare respect\u0103 cu adev\u0103rat regulile lui Mendel. Cu toate acestea, exist\u0103 dou\u0103 tipuri de genomuri care asigur\u0103 func\u021bionarea mitocondriilor: ADN-ul mitocondrial (transmis doar pe linia matern\u0103) \u0219i ADN-ul nuclear (mo\u0219tenit de la ambii p\u0103rin\u021bi). Drept urmare, tipurile de mo\u0219tenire variaz\u0103 de la autosomal dominant la autosomal recesiv, precum \u0219i la transmiterea materialului genetic pe linia matern\u0103. <\/p>\n<p>Situa\u021bia este complicat\u0103 \u0219i mai mult de faptul c\u0103 \u00een celul\u0103 se dezvolt\u0103 interac\u021biuni complexe \u00eentre ADN-ul mitocondrial \u0219i ADN-ul nuclear. Drept rezultat, acelea\u0219i muta\u021bii ale ADN-ului mitocondrial pot provoca simptome foarte diferite la fra\u021bi care tr\u0103iesc \u00een aceea\u0219i familie (ace\u0219tia pot avea ADN nuclear diferit, dar acela\u0219i ADN mitocondrial), \u00een timp ce muta\u021biile pot cauza simptome identice. Chiar \u0219i gemenii cu diagnostice identice pot avea imagini clinice radical diferite ale bolii (simptomele specifice depind de \u021besuturile afectate de procesul patogen), \u00een timp ce persoanele cu muta\u021bii pot suferi de simptome similare, care formeaz\u0103 aceea\u0219i imagine a bolii. <\/p>\n<p>Indiferent de situa\u021bie, \u00een ovocitul matern exist\u0103 o mare varietate de ADN mitocondrial, iar acest fapt diminueaz\u0103 valoarea tuturor previziunilor legate de rezultatele mo\u0219tenirii genetice. Natura acestui grup de boli este at\u00e2t de haotic\u0103, \u00eenc\u00e2t setul de simptome corespunz\u0103toare acestor afec\u021biuni se poate schimba de la un deceniu la altul \u0219i poate varia chiar \u0219i \u00eentre fra\u021bi cu muta\u021bii identice ale ADN-ului mitocondrial. Mai mult, uneori sindromul mitocondrial poate disp\u0103rea pur \u0219i simplu, \u00een ciuda faptului c\u0103 a fost (sau ar fi trebuit s\u0103 fie) mo\u0219tenit. Dar astfel de cazuri fericite sunt rare, iar cel mai adesea bolile mitocondriale progreseaz\u0103. Tabelul 2.2 \u0219i 2.3 prezint\u0103 bolile \u0219i simptomele asociate cu disfunc\u021bia mitocondrial\u0103, precum \u0219i factorii genetici ai acestor afec\u021biuni. \u00cen prezent, \u0219tiin\u021ba cunoa\u0219te peste 200 de tipuri de muta\u021bii mitocondriale. Rezultatele cercet\u0103rilor sugereaz\u0103 c\u0103 multe boli degenerative sunt cauzate de astfel de muta\u021bii (ceea ce \u00eenseamn\u0103 c\u0103 trebuie s\u0103 reclasific\u0103m un num\u0103r uria\u0219 de boli, mut\u00e2ndu-le \u00een categoria bolilor mitocondriale). <\/p>\n<p>Dup\u0103 cum \u0219tim, aceste muta\u021bii pot duce la \u00eencetarea func\u021biei mitocondriilor de a produce energie, ceea ce poate provoca oprirea activit\u0103\u021bii celulare sau moartea acestora. Toate celulele (cu excep\u021bia globulelor ro\u0219ii) con\u021bin mitocondrii, iar, prin urmare, sindromul mitocondrial afecteaz\u0103 sisteme multicompuse \u0219i foarte diverse ale organismului (\u00een paralel sau succesiv).<\/p>\n<p>Tabelul 2.2. Semne, simptome \u0219i boli cauzate de disfunc\u021bia mitocondrial\u0103<\/p>\n<p><img decoding=\"async\" alt=\"Cartea \u00abMitocondria egoist\u0103. Cum s\u0103 ne p\u0103str\u0103m s\u0103n\u0103tatea \u0219i s\u0103 am\u00e2n\u0103m \u00eemb\u0103tr\u00e2nirea\u00bb\" src=\"\/wp-content\/uploads\/2019\/10\/8cf02107cc45962c50e063714c2a350f.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\nTabelul 2.3. Boli congenitale cauzate de disfunc\u021bia mitocondrial\u0103<\/p>\n<p><img decoding=\"async\" alt=\"Cartea \u00abMitocondria egoist\u0103. Cum s\u0103 ne p\u0103str\u0103m s\u0103n\u0103tatea \u0219i s\u0103 am\u00e2n\u0103m \u00eemb\u0103tr\u00e2nirea\u00bb\" src=\"\/wp-content\/uploads\/2019\/10\/2feee61f1963b425e9bb79a063e93bed.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\nDesigur, unele organe sau \u021besuturi au nevoie de mai mult\u0103 energie dec\u00e2t altele. C\u00e2nd nevoile energetice ale unui anumit organ nu pot fi satisf\u0103cute complet, apar simptomele sindromului mitocondrial. \u00cen primul r\u00e2nd, acestea afecteaz\u0103 func\u021biile creierului, sistemului nervos, mu\u0219chilor, inimii, rinichilor \u0219i sistemului endocrin, adic\u0103 toate organele care necesit\u0103 o cantitate mare de energie pentru a func\u021biona normal.<\/p>\n<h3>Boli dob\u00e2ndite cauzate de disfunc\u021bia mitocondrial\u0103<\/h3>\n<p>\nPe m\u0103sur\u0103 ce ne cre\u0219te \u00een\u021belegerea func\u021biei \u0219i disfunc\u021biei mitocondriale, \u00eencepem s\u0103 cre\u0103m o list\u0103 lung\u0103 de boli care au la baz\u0103 disfunc\u021bia mitocondrial\u0103 \u0219i s\u0103 clarific\u0103m mecanismele apari\u021biei \u0219i dezvolt\u0103rii acestor afec\u021biuni. Datele unor cercet\u0103ri recente sugereaz\u0103 c\u0103 sindromul mitocondrial afecteaz\u0103 unul din 2500 de oameni. Cu toate acestea, dac\u0103 examin\u0103m cu aten\u021bie lista de mai jos, vom fi de acord c\u0103, cu o mare probabilitate, bolile mitocondriale (congenitale sau dob\u00e2ndite) vor fi observate la fiecare al 25-lea sau chiar la fiecare al 10-lea locuitor al \u021b\u0103rilor occidentale.<\/p>\n<ul>\n<li>Diabet de tip II<\/li>\n<li>Bolile oncologice<\/li>\n<li>Boala Alzheimer<\/li>\n<li>Boala Parkinson<\/li>\n<li>Tulburare afectiv\u0103 bipolar\u0103<\/li>\n<li>\u0218izofrenie<\/li>\n<li>\u00cemb\u0103tr\u00e2nire \u0219i senilitate<\/li>\n<li>Tulburare de anxietate<\/li>\n<li>Steatoz\u0103 hepatic\u0103 non-alcoolic\u0103<\/li>\n<li>Boli cardiovasculare<\/li>\n<li>Sarcopenie (pierdere \u00een mas\u0103 \u0219i for\u021b\u0103 muscular\u0103)<\/li>\n<li>Intoleran\u021b\u0103 la efort<\/li>\n<li>Oboseal\u0103, inclusiv sindromul de oboseal\u0103 cronic\u0103, fibromialgia \u0219i durerile miofasciale<\/li>\n<\/ul>\n<p>\nLa nivel genetic, toate acestea sunt legate de procese foarte complexe. Puterea energetic\u0103 a unei persoane specifice poate fi determinat\u0103 prin cercetarea defectelor \u00eenn\u0103scute ale ADN-ului mitocondrial. Dar aceasta este doar un punct de plecare. Pe parcursul timpului, \u00een organism se acumuleaz\u0103 defecte dob\u00e2ndite ale ADN-ului mitocondrial, iar dup\u0103 ce un organ sau altul dep\u0103\u0219e\u0219te un anumit prag, \u00eencepe s\u0103 func\u021bioneze defectuos sau devine predispus la degenerare (fiecare organ are propriul s\u0103u prag de toleran\u021b\u0103, despre care vom discuta mai \u00een detaliu). <\/p>\n<p>O alt\u0103 complexitate const\u0103 \u00een faptul c\u0103 fiecare mitocondrie include p\u00e2n\u0103 la zece copii de ADN mitocondrial, iar fiecare celul\u0103, fiecare \u021besut \u0219i fiecare organ au numeroase mitocondrii. Deci, \u00een organismul nostru nu se pot num\u0103ra defectele din copiile ADN-ului mitocondrial. Disfunc\u021bia unui organ specific \u00eencepe atunci c\u00e2nd procentul mitocondriilor defectuoase din el dep\u0103\u0219e\u0219te o anumit\u0103 valoare. Acest fenomen se nume\u0219te efectul prag36. Fiecare organ \u0219i fiecare \u021besut sunt supuse muta\u021biilor specifice \u0219i se caracterizeaz\u0103 prin propriul prag de muta\u021bie, necesit\u0103\u021bile energetice \u0219i rezisten\u021ba la influen\u021bele radicalilor liberi. Combina\u021bia acestor factori determin\u0103 exact cum va reac\u021biona un sistem viu la tulbur\u0103rile genetice. <\/p>\n<p>Dac\u0103 doar 10 % dintre mitocondrii sunt defectuo\u0219i, 90 % dintre generatorii normali de energie celular\u0103 r\u0103ma\u0219i pot compensa disfunc\u021bia \u201ecolaboratorilor\u201d lor. Sau, de exemplu, dac\u0103 o muta\u021bie nu este foarte grav\u0103, dar a afectat un num\u0103r mare de mitocondrii, celula poate func\u021biona \u00een continuare normal. <\/p>\n<p>Exist\u0103 de asemenea conceptul de segregare a mitocondriilor defecte: \u00een timpul diviz\u0103rii celulei, mitocondriile sale sunt distribuite aleatoriu \u00eentre cele dou\u0103 celule fiice. Una dintre aceste celule poate ob\u021bine toate mitocondriile mutate, \u00een timp ce cealalt\u0103 poate s\u0103 dob\u00e2ndeasc\u0103 toate \u201ecentralele electrice\u201d func\u021bionale (evident, variante intermediare sunt mai probabile). Celulele cu mitocondrii disfunc\u021bionale vor muri \u00een procesul de apoptoz\u0103, iar cele s\u0103n\u0103toase vor continua s\u0103 \u00ee\u0219i \u00eendeplineasc\u0103 rolul (o explica\u021bie pentru dispari\u021bia brusc\u0103 \u0219i nea\u0219teptat\u0103 a sindromului mitocondrial). Fenomenul diferen\u021belor \u00een secven\u021ba ADN-ului mitocondrial (sau cloroplastului) \u00een aceea\u0219i organism, adesea chiar \u00een aceea\u0219i celul\u0103, c\u00e2nd unele mitocondrii, de exemplu, pot con\u021bine o anumit\u0103 muta\u021bie patologic\u0103, iar altele nu, se nume\u0219te heteroplasmie. Gradul de heteroplasmie variaz\u0103 chiar \u0219i \u00eentre membrii acelea\u0219i familii. Mai mult, nivelul de heteroplasmie poate fluctua chiar \u0219i \u00een cadrul acelea\u0219i organisme, \u00een func\u021bie de organul specific sau de celula specific\u0103, ceea ce duce la un interval foarte larg de manifest\u0103ri \u0219i simptome ale unei anumite boli mitocondriale. <\/p>\n<p>\u00cen organismul unui embrion \u00een cre\u0219tere, pe m\u0103sur\u0103 ce celulele se divid, mitocondriile cu muta\u021bii umplu organele \u0219i \u021besuturile, care difer\u0103 \u00eentre ele \u00een func\u021bie de nevoile lor energetice. \u0218i dac\u0103 mitocondriile mutate se afl\u0103 \u00een num\u0103r mare \u00een celulele care, \u00een timp, se transform\u0103 \u00een structuri metabolice active (de exemplu, creierul sau inima), organismul \u00een cauz\u0103 are ulterior probleme cu calitatea vie\u021bii (dac\u0103 este viabil). Pe de alt\u0103 parte, dac\u0103 masa mitocondriilor disfunc\u021bionale se acumuleaz\u0103, \u00een primul r\u00e2nd, \u00een celule cu intensitate metabolic\u0103 sc\u0103zut\u0103 (s\u0103 spunem, \u00een celulele pielii, care se schimb\u0103 regulat una dup\u0103 alta), atunci purt\u0103torul acestor mitocondrii poate s\u0103 nu afle niciodat\u0103 despre predispozi\u021bia sa genetic\u0103 la sindromul mitocondrial. \u00cen episodul men\u021bionat mai sus din \u201eBachelorette\u201d, una dintre fete cu boal\u0103 mitocondrial\u0103 p\u0103rea complet normal\u0103, \u00een timp ce cealalt\u0103 suferea evident de o afec\u021biune grav\u0103. <\/p>\n<p>Unele muta\u021bii mitocondriale se dezvolt\u0103 spontan pe m\u0103sur\u0103 ce \u00eenaint\u0103m \u00een v\u00e2rst\u0103, ca rezultat al form\u0103rii radicalilor liberi \u00een timpul metabolismului normal. Ceea ce se \u00eent\u00e2mpl\u0103 apoi depinde de o serie de factori. De exemplu, dac\u0103 o celul\u0103 plin\u0103 de mitocondrii disfunc\u021bionale se divide rapid, a\u0219a cum o fac celulele stem \u00een cadrul regener\u0103rii \u021besuturilor, generatorii de energie defectuo\u0219i vor extinde activ. Dac\u0103 \u00eens\u0103 o celul\u0103 sl\u0103bit\u0103 nu se mai divide (s\u0103 presupunem c\u0103 este vorba despre un neuron), muta\u021biile vor r\u0103m\u00e2ne confinate doar acestei celule, ceea ce, totu\u0219i, nu exclude posibilitatea unei muta\u021bii accidentale de succes. A\u0219adar, tocmai complexitatea bazei genetice a sindromului mitocondrial explic\u0103 faptul c\u0103 epuizarea resurselor bioenergetice ale organismului, cauzat\u0103 de muta\u021biile mitocondriale, se manifest\u0103 \u00eentr-un spectru larg de boli \u0219i simptome diverse \u0219i complexe. <\/p>\n<p>Trebuie s\u0103 ne amintim \u0219i c\u0103 exist\u0103 numeroase gene \u00een afara ADN-ului mitocondrial care sunt responsabile pentru func\u021bionarea normal\u0103 a mitocondriilor. Dac\u0103 o muta\u021bie afecteaz\u0103 genele care codific\u0103 ARN-ul, consecin\u021bele sunt de obicei destul de grave. \u00cen cazurile \u00een care un copil mo\u0219tene\u0219te, la concep\u021bie, de la oricare dintre p\u0103rin\u021bi, un factor de transcrip\u021bie mitocondrial mutat (s\u0103 ne amintim c\u0103 factorii de transcrip\u021bie sunt proteine care controleaz\u0103 procesul de sintez\u0103 a ARN-ului mesager pe matricea ADN-ului prin legarea de regiuni specifice ale ADN-ului), toate mitocondriile din organismul s\u0103u vor fi supuse influen\u021bei patogene. Cu toate acestea, dac\u0103 muta\u021bia se refer\u0103 doar la factori de transcrip\u021bie specifici, care sunt activa\u021bi doar \u00een anumite organe sau \u021besuturi sau ca r\u0103spuns la eliberarea unui hormon specific, atunci efectul patogen corespunz\u0103tor va fi exclusiv local.<\/p>\n<p>Gama larg\u0103 de boli mitocondriale \u0219i manifest\u0103rile acestora reprezint\u0103 o problem\u0103 serioas\u0103 pentru medici (at\u00e2t teoretic, c\u00e2t \u0219i practic), inclusiv imposibilitatea de a prezice dezvoltarea sindromului mitocondrial. Exist\u0103 at\u00e2t de multe boli mitocondriale, \u00eenc\u00e2t este dificil chiar \u0219i s\u0103 le d\u0103m nume, iar multe dintre ele nu au fost descoperite \u00eenc\u0103. Chiar \u0219i o serie de boli degenerative cunoscute (boli cardiovasculare, boli oncologice, diverse forme de demen\u021b\u0103 etc.) sunt considerate de \u0219tiin\u021ba modern\u0103 ca fiind o disfunc\u021bie a mitocondriilor.<\/p>\n<p>Este important s\u0103 ne d\u0103m seama c\u0103, de\u0219i nu exist\u0103 un tratament complet pentru bolile mitocondriale, multe persoane cu aceste afec\u021biuni (\u00een special dac\u0103 este vorba despre forme u\u0219oare sau moderate ale bolii) pot tr\u0103i mult \u0219i bine. Totu\u0219i, pentru aceasta este necesar s\u0103 se lucreze sistematic, utiliz\u00e2nd cuno\u0219tin\u021bele de care dispunem.<\/p>\n<h3>Despre autor<\/h3>\n<p>\n<b>Li Nou<\/b> \u2014 medic naturopat licen\u021biat din Canada, de\u021bin\u0103tor al mai multor premii. Colegii \u00eel cunosc ca pe un antreprenor prev\u0103z\u0103tor, strateg \u0219i medic. Li a ocupat func\u021bii de consultant medical, expert \u0219tiin\u021bific \u0219i director de cercetare \u0219i dezvoltare \u00een organiza\u021bii mari. Pe l\u00e2ng\u0103 activitatea \u0219tiin\u021bific\u0103 din compania sa, este de asemenea consultant \u00een produse naturale pentru s\u0103n\u0103tate \u0219i suplimente alimentare, \u0219i face parte din consiliul editorial \u0219i consultativ al revistei Alive \u2014 cea mai citit\u0103 revist\u0103 de s\u0103n\u0103tate din Canada. \u00ce\u0219i nume\u0219te acas\u0103 zona Marii Toronto, unde locuie\u0219te cu so\u021bia sa \u0219i cei doi fii ai lor, av\u00e2nd un interes deosebit \u00een fortificarea s\u0103n\u0103t\u0103\u021bii naturale \u0219i protec\u021bia mediului.<\/p>\n<p>\u00bb Pute\u021bi g\u0103si mai multe detalii despre carte pe <noindex><a rel=\"nofollow\" href=\"https:\/\/www.piter.com\/collection\/best\/product\/egoistichnaya-mitohondriya-kak-sohranit-zdorovie-i-otodvinut-starost?_gs_cttl=120&amp;gs_direct_link=1&amp;gsaid=82744&amp;gsmid=29789&amp;gstid=c\">site-ul editurii<\/a><\/noindex><br \/>\n\u00bb <noindex><a rel=\"nofollow\" href=\"https:\/\/storage.piter.com\/upload\/contents\/978544611021\/978544611021_X.pdf\">Cuprins<\/a><\/noindex><br \/>\n\u00bb <noindex><a rel=\"nofollow\" href=\"https:\/\/storage.piter.com\/upload\/contents\/978544611021\/978544611021_p.pdf\">Fragment<\/a><\/noindex><\/p>\n<p>Pentru utilizatorii Habr, discount de 25% cu codul \u2014 <b>Mitocondria<\/b><\/p>\n<p>Dup\u0103 plata versiunii tip\u0103rite a c\u0103r\u021bii, se va trimite o carte electronic\u0103 pe e-mail.<br \/>\n<br \/>Sursa: <a content=\"nofollow\" rel=\"nofollow\" href=\"https:\/\/habr.com\/ru\/company\/piter\/blog\/471704\/\">habr.com<\/a><\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>\u041c\u0435\u0447\u0442\u0430 \u043b\u044e\u0431\u043e\u0433\u043e \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u2014 \u043e\u0441\u0442\u0430\u0432\u0430\u0442\u044c\u0441\u044f \u043c\u043e\u043b\u043e\u0434\u044b\u043c \u043a\u0430\u043a \u043c\u043e\u0436\u043d\u043e \u0434\u043e\u043b\u044c\u0448\u0435. \u041c\u044b \u043d\u0435 \u0445\u043e\u0442\u0438\u043c \u0441\u0442\u0430\u0440\u0435\u0442\u044c \u0438 \u0431\u043e\u043b\u0435\u0442\u044c, \u0431\u043e\u0438\u043c\u0441\u044f \u0432\u0441\u0435\u0433\u043e \u2014 \u0440\u0430\u043a\u0430, \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0410\u043b\u044c\u0446\u0433\u0435\u0439\u043c\u0435\u0440\u0430, \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0430, \u0438\u043d\u0441\u0443\u043b\u044c\u0442\u0430\u2026 \u041f\u043e\u0440\u0430 \u0440\u0430\u0437\u043e\u0431\u0440\u0430\u0442\u044c\u0441\u044f, \u043e\u0442\u043a\u0443\u0434\u0430 \u0431\u0435\u0440\u0435\u0442\u0441\u044f \u0440\u0430\u043a, \u0435\u0441\u0442\u044c \u043b\u0438 \u0441\u0432\u044f\u0437\u044c \u043c\u0435\u0436\u0434\u0443 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c\u044e \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0410\u043b\u044c\u0446\u0433\u0435\u0439\u043c\u0435\u0440\u0430, \u0431\u0435\u0441\u043f\u043b\u043e\u0434\u0438\u0435\u043c \u0438 \u043f\u043e\u0442\u0435\u0440\u0435\u0439 \u0441\u043b\u0443\u0445\u0430. \u041f\u043e\u0447\u0435\u043c\u0443 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u044b\u0435 \u0434\u043e\u0431\u0430\u0432\u043a\u0438 \u0438\u043d\u043e\u0433\u0434\u0430 \u043f\u0440\u0438\u043d\u043e\u0441\u044f\u0442 \u0431\u043e\u043b\u044c\u0448\u0435 \u0432\u0440\u0435\u0434\u0430, \u0447\u0435\u043c \u043f\u043e\u043b\u044c\u0437\u044b? \u0418 \u0433\u043b\u0430\u0432\u043d\u043e\u0435: \u043c\u043e\u0436\u0435\u043c \u043b\u0438 \u043c\u044b [&hellip;]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":29288,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[702],"tags":[],"class_list":["post-39037","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.2 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Yuri Gagarin\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/prohoster.info\/ro\/blog\/news\/kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.2\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"ProHoster | \u041a\u0443\u043f\u0438\u0442\u044c \u043d\u0430\u0434\u0435\u0436\u043d\u044b\u0439 \u0445\u043e\u0441\u0442\u0438\u043d\u0433 \u0434\u043b\u044f \u0441\u0430\u0439\u0442\u043e\u0432 \u0441 \u0437\u0430\u0449\u0438\u0442\u043e\u0439 \u043e\u0442 DDoS, VPS VDS \u0441\u0435\u0440\u0432\u0435\u0440\u044b\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"\ud83e\udd47\u041a\u043d\u0438\u0433\u0430 \u00ab\u042d\u0433\u043e\u0438\u0441\u0442\u0438\u0447\u043d\u0430\u044f \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u044f. \u041a\u0430\u043a \u0441\u043e\u0445\u0440\u0430\u043d\u0438\u0442\u044c \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u0435 \u0438 \u043e\u0442\u043e\u0434\u0432\u0438\u043d\u0443\u0442\u044c \u0441\u0442\u0430\u0440\u043e\u0441\u0442\u044c\u00bb | ProHoster\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/prohoster.info\/ro\/blog\/news\/kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/prohoster.info\/wp-content\/uploads\/2021\/11\/logo-350.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/prohoster.info\/wp-content\/uploads\/2021\/11\/logo-350.jpg\" \/>\n\t\t<meta property=\"og:image:width\" content=\"350\" \/>\n\t\t<meta property=\"og:image:height\" content=\"350\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2019-10-31T19:27:31+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2019-10-31T19:27:31+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prohoster\" \/>\n\t\t<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/prohoster\" \/>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"\ud83e\udd47Cartea \u201eMitocondria egoist\u0103. Cum s\u0103 ne men\u021binem s\u0103n\u0103tatea \u0219i s\u0103 ne am\u00e2n\u0103m \u00eemb\u0103tr\u00e2nirea\u201d | ProHoster","description":"","canonical_url":"https:\/\/prohoster.info\/ro\/blog\/news\/kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":null,"og:locale":"ro_RO","og:site_name":"ProHoster | \u041a\u0443\u043f\u0438\u0442\u044c \u043d\u0430\u0434\u0435\u0436\u043d\u044b\u0439 \u0445\u043e\u0441\u0442\u0438\u043d\u0433 \u0434\u043b\u044f \u0441\u0430\u0439\u0442\u043e\u0432 \u0441 \u0437\u0430\u0449\u0438\u0442\u043e\u0439 \u043e\u0442 DDoS, VPS VDS \u0441\u0435\u0440\u0432\u0435\u0440\u044b","og:type":"article","og:title":"\ud83e\udd47\u041a\u043d\u0438\u0433\u0430 \u00ab\u042d\u0433\u043e\u0438\u0441\u0442\u0438\u0447\u043d\u0430\u044f \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u044f. \u041a\u0430\u043a \u0441\u043e\u0445\u0440\u0430\u043d\u0438\u0442\u044c \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u0435 \u0438 \u043e\u0442\u043e\u0434\u0432\u0438\u043d\u0443\u0442\u044c \u0441\u0442\u0430\u0440\u043e\u0441\u0442\u044c\u00bb | ProHoster","og:url":"https:\/\/prohoster.info\/ro\/blog\/news\/kniga-egoistichnaya-mitohondriya-kak-sohranit-zdorove-i-otodvinut-starost","og:image":"https:\/\/prohoster.info\/wp-content\/uploads\/2021\/11\/logo-350.jpg","og:image:secure_url":"https:\/\/prohoster.info\/wp-content\/uploads\/2021\/11\/logo-350.jpg","og:image:width":350,"og:image:height":350,"article:published_time":"2019-10-31T19:27:31+00:00","article:modified_time":"2019-10-31T19:27:31+00:00","article:publisher":"https:\/\/www.facebook.com\/prohoster","article:author":"https:\/\/www.facebook.com\/prohoster"},"aioseo_meta_data":{"post_id":"39037","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":null,"schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"seo_analyzer_scan_date":"2026-01-24 00:30:19","breadcrumb_settings":null,"limit_modified_date":false,"reviewed_by":null,"ai":null,"created":"2021-03-01 00:58:37","updated":"2026-01-24 00:30:19","focus_keyword":null,"additional_keywords":null,"truseo_locale":null},"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/posts\/39037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/comments?post=39037"}],"version-history":[{"count":0,"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/posts\/39037\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/media\/29288"}],"wp:attachment":[{"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/media?parent=39037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/categories?post=39037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prohoster.info\/ro\/wp-json\/wp\/v2\/tags?post=39037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}