Mhoro! Yekutanga pasi rose kuchengetedza data mumamorekuru eDNA

Vatsvagiri veMicrosoft neYunivhesiti yeWashington vakaratidza yekutanga otomatiki, inoverengeka data yekuchengetedza dhizaini yeDNA yakagadzirwa nemaoko. Iri inhanho yakakosha yekufambisa tekinoroji nyowani kubva kumalabhu ekutsvagisa kuenda kunzvimbo dzekutengesa data.

Vagadziri vakaratidza pfungwa iyi nebvunzo yakapusa: vakabudirira kukodha izwi rekuti "mhoroi" muzvidimbu zveiyo synthetic DNA molecule uye vakaidzosera kuita data redhijitari vachishandisa yakazara otomatiki yekupedzisira-yekupedzisira system, inotsanangurwa mukati. chinyorwa, rakabudiswa muna March 21 muNature Scientific Reports.

Ichi chinyorwa chiri pawebhusaiti yedu.

Mamorekuru eDNA anogona kuchengeta ruzivo rwedhijitari pakadhinanisirwa zvakanyanya, ndiko kuti, munzvimbo ine maodha akawanda ehukuru idiki pane inogarwa nedata data centers. Ndiyo imwe yemhinduro dzinovimbisa dzekuchengetedza huwandu hukuru hwe data iro nyika inogadzira zuva rega rega, kubva kumarekodhi ebhizinesi uye mavhidhiyo emhuka dzakanaka kusvika kumifananidzo yekurapa nemifananidzo kubva muchadenga.

Microsoft iri kutsvaga nzira dzekuvhara mukana ungangoita pakati huwandu hwe data yatinoburitsa uye tinoda kuchengetedza, nekugona kwedu kuzvichengeta. Idzi nzira dzinosanganisira kuvandudzwa kwealgorithms uye molecular computing technologies ye encoding data muArtificial DNA. Izvi zvaizobvumira ruzivo rwese rwakachengetwa munzvimbo huru yemazuva ano yedata kuti ikwane munzvimbo inokwana saizi yemadhayisi akati wandei.

"Chinangwa chedu chikuru ndechekuisa mukugadzira sisitimu iyo, kumushandisi wekupedzisira, inotaridzika yakada kufanana nechero imwe nzira yekuchengetera gore: ruzivo rwunotumirwa kunzvimbo yedata uye inochengetwa ipapo, uye inongoonekwa kana mutengi achiida. ,” anodaro Sr. Microsoft muongorori Karin Strauss. "Kuti tiite izvi, taifanira kuratidza kuti zvine musoro kubva pakuona otomatiki."

Ruzivo rwunochengetwa mumamorekuru eDNA akagadzirwa murabhoritari, kwete muDNA yevanhu kana zvimwe zvipenyu, uye anogona kuvharirwa asati atumirwa kuhurongwa. Kunyangwe michina yakaoma yakadai semasynthesizer uye sequencers inotoita zvikamu zvakakosha zvehurongwa, mazhinji ematanho epakati ave kutoda basa remaoko murabhoritari yekutsvagisa. "Hazvina kukodzera kushandiswa kwekutengesa," akadaro Chris Takahashi, mumwe mukuru wekutsvagisa paPaul Allen Chikoro cheComputer Science uye Engineering kuUSF (Paul G. Allen Chikoro cheComputer Science & Engineering).

"Haugone kuita kuti vanhu vamhanye kutenderera nzvimbo yedata nemapipettes, yakanyanya kukanganisa kukanganisa kwevanhu, inodhura uye inotora nzvimbo yakawandisa," Takahashi akatsanangura.

Kuti nzira iyi yekuchengetera data ive ine musoro mune zvekutengesa, mutengo wezvose zviri zviviri DNA synthesis - kugadzira matombo anokosha ekuvaka enhevedzano ine revo - uye nzira yekutevedzana inodiwa pakuverenga ruzivo rwakachengetwa inofanira kuderedzwa. Vatsvakurudzi vanoti iyi ndiyo nzira kukurumidza kukura.

Automation chimwe chidimbu chakakosha chepuzzle, ichiita kuchengetedza data pachiyero chekutengesa uye chinodhura, sekureva kwevatsvagiri veMicrosoft.

Mune mamwe mamiriro ezvinhu, DNA inogona kugara kwenguva yakareba kupfuura masisitimu emazuva ano ekuchengetera zvinyorwa, ayo anodzikisira kwemakumi emakore. Imwe DNA yakakwanisa kurarama mumamiriro ezvinhu asina kunaka kwemakumi ezviuru zvemakore—mumazinyanga makuru uye mumapfupa evanhu vepakutanga. Izvi zvinoreva kuti data inogona kuchengetwa nenzira iyi chero bedzi vanhu varipo.

Iyo automated DNA yekuchengetedza sisitimu inoshandisa software yakagadzirwa neMicrosoft neYunivhesiti yeWashington (UW). Inoshandura iyo uye zero yedhijitari data kuita nhevedzano yemanucleotides (A, T, C uye G), ayo ari "zvivharo zvekuvaka" zveDNA. Iyo sisitimu inozoshandisa isingadhuri, kazhinji isiri-pasherufu, midziyo yemurabhoritari kupa mvura inodiwa uye reagents kune synthesizer, iyo inounganidza zvidimbu zveDNA zvakagadzirwa uye zvinozviisa mumudziyo wekuchengetera.

Kana gadziriro yacho ichida kubuditsa mashoko, inowedzera mamwe makemikoro kuti igadzirire DNA zvakanaka uye inoshandisa pombi ine microfluidic kusundira mvura muzvikamu zvegadziriro inoverenga kutevedzana kwemamorekuru eDNA yoachinja kuti ave mashoko anogona kunzwisiswa nekombiyuta. Vatsvagiri vanoti chinangwa chechirongwa ichi chaive chisiri chekuratidza kuti hurongwa hwaigona kushanda nekukurumidza kana zvakachipa, asi kungoratidza kuti otomatiki yaigona.

Imwe yemabhenefiti ari pachena eiyo otomatiki yekuchengetera DNA system ndeyekuti inosunungura masayendisiti kugadzirisa matambudziko akaomarara pasina kutambisa nguva kutsvaga mabhodhoro emareagents kana monotony yekuwedzera madonhwe emvura mumachubhu ekuedzwa.

"Kuva neautomated system yekuita basa rekudzokorora kunobvumira maLab kuti atarise zvakananga pakutsvaga uye kugadzira nzira nyowani dzekuvandudza nekukurumidza," akadaro Microsoft muongorori Bihlin Nguyen.

Chikwata kubva kuLabhoritari yeMolecular Information Systems Molecular Information Systems Lab (MISL) yakatoratidza kuti inogona kuchengeta mafoto ekitsi, mabasa anoshamisa emabhuku, видео uye yakachengetwa marekodhi eDNA uye kubvisa mafaera aya pasina zvikanganiso. Kusvika iye zvino, vakakwanisa kuchengetedza 1 gigabyte yedata muDNA, vachirova rekodhi yenyika yapfuura ye200 MB.

Vatsvakurudzi vakagadzirawo nzira dzekuita ita masvomhu ane musorozvakadai sekutsvaga nekutora mifananidzo chete ine apuro kana bhasikoro rakasvibirira richishandisa mamorekuru pachawo, pasina kushandura mafaira kudzokera kudhijitari format.

"Zvakanaka kutaura kuti tiri kuona kuberekwa kwerudzi rutsva rwekombuta, umo mamorekuru anoshandiswa kuchengetedza data uye zvemagetsi kudzora nekugadzirisa. Musanganiswa uyu unovhura mikana inonakidza yeramangwana, "akadaro purofesa weAllen School paYunivhesiti yeWashington. Louis Sese.

Kusiyana nesilicon-based computing systems, DNA-based storage uye computing systems inofanira kushandisa zvinwiwa kufambisa mamorekuru. Asi zvinwiwa zvakasiyana mumasikirwo kubva kune maerekitironi uye zvinoda mhinduro nyowani dzehunyanzvi.

Chikwata cheYunivhesiti yeWashington, chakabatana neMicrosoft, chiri kugadzirawo hurongwa hunogona kuita otomatiki kuyedza murabhoritari nekushandisa zvinhu zvemagetsi nemvura kufambisa madonhwe pagridi remagetsi. Seti yakakwana yesoftware uye hardware inonzi Puddle uye PurpleDrop, inogona kusanganisa, kupatsanura, kupisa kana kutonhodza zvinwiwa zvakasiyana siyana uye kuita zvirevo zverabhoritari.

Chinangwa ndechekuita otomatiki kuyedza murabhoritari iko zvino kuri kuitwa nemaoko kana nemarobhoti anodhura ekubata mvura uye kuderedza mitengo.

Matanho anotevera echikwata cheMISL anosanganisira kubatanidza yakapfava, yekupedzisira-kumagumo otomatiki sisitimu ine matekinoroji akadai sePurple Drop, pamwe nehumwe matekinoroji anogonesa kutsvaga mamorekuru eDNA. Vatsvagiri vakaita nemaune yavo otomatiki sisitimu modular kuitira kuti igone kushanduka sematekinoroji matsva eDNA synthesis, kutevedzana uye kunyengera kwakabuda.

"Chimwe chezvibatsiro zvegadziriro iyi ndechokuti kana tichida kutsiva chimwe chezvikamu nechimwe chinhu chitsva, chiri nani kana kukurumidza, tinogona kungovhara muchikamu chitsva," akadaro Nguyen. "Izvi zvinotipa kuchinjika kune ramangwana."

Mufananidzo wepamusoro: Vatsvagiri kubva kuMicrosoft neYunivhesiti yeWashington vakarekodha uye vakaverenga izwi rekuti "mhoro", uchishandisa yekutanga yakazara yakazara DNA data yekuchengetedza system. Iri inhanho yakakosha pakufambisa tekinoroji nyowani kubva kumarabhoritari kuenda kunzvimbo dzekutengesa data.

Source: www.habr.com