Chiroto chemunhu wese ndechekugara mudiki kwenguva yakareba sezvinobvira. Hatidi kukwegura uye kurwara, tinotya zvose - kenza, chirwere cheAlzheimer, chirwere chemwoyo, sitiroko ... Inguva yekuziva kuti kenza inobva kupi, kana pane kubatana pakati pekukundikana kwemoyo neAlzheimer's. chirwere, kushaya mbereko uye kurasikirwa nekunzwa. Nei antioxidant supplements dzimwe nguva ichikuvadza zvakanyanya pane zvakanaka? Uye zvinonyanya kukosha: tinogona kurarama kwenguva refu uye pasina chirwere, uye kana zvakadaro, sei?
Muviri wedu une diki "zviteshi zvesimba" zvinonzi mitochondria. Ndivo vane basa rehutano hwedu nekugara zvakanaka. Pavanoshanda zvakanaka, hatishayi simba. Uye kana zvakaipa, tinotambura nezvirwere. Dr. Lee Ziva anoratidza chakavanzika: zvirwere zvinoita sezvisingabatanidzi pakutanga: chirwere cheshuga, kenza, schizophrenia, kuneta kusingaperi, chirwere cheParkinson nevamwe - vane chimiro chakafanana.
Nhasi tinoziva nzira yekuvandudza kushanda kwemitochondria, iyo inopa muviri 90% yesimba. Bhuku rino richakupa ruzivo rwechizvino-zvino pamusoro pekudya, mararamiro, ketogenic kudya, uye zvinowedzera zvinodzoreredza mitochondria ine hutano, uye nekudaro isu.
Excerpt. Mitochondrial syndrome
Ndinonyara kubvuma izvi, asi ini ndaive muoni weiyo chaiyo show "The Bachelor." Ndakafadzwa zvikuru nechikamu chechitatu cheSeason 17 (Ndira 2013), umo Chivi (the Bachelor) naAshley (the Contender) vakaenda kunosangana nevasikana vaviri vairwara nechirwere chemitochondrial. Kune vazhinji venyu, kana wakatarisa chikamu, iyi yaive sumo yako yekutanga kune mitochondrial syndrome (mitochondrial syndrome yakaoma yezvirwere zvine chekuita nekukuvadzwa kwekuzvarwa kune mitochondria). Nekudaro, boka iri rezvirwere riri kuramba richidzidzwa sezvo ongororo yemajini uye genetic sequencing matekinoroji anova nyore, akachipa uye anowanikwa nyore.
Kusvika ma80 ekutanga, apo mitochondrial genome yemunhu yakanyatso kutevedzana, mishumo yezvirwere zvemitochondrial yaive isingawanzo. Mamiriro ezvinhu akachinja nekukwanisa kutsanangura mtDNA yevarwere vazhinji. Izvi zvakakonzera kuwedzera kwakanyanya kwenhamba yevarwere vakashumwa vanorwara nezvirwere zvakagarwa nhaka zvemitochondrial. Nhamba yavo inosanganisira inenge imwe muvashanu (kana kunyange maviri nehafu) zviuru zvevanhu. Pano isu hatitarise vanhu vane zvinyoro zvimiro zvezvirwere zvemitochondrial. Mukuwedzera, rondedzero yezviratidzo zvemitochondrial syndrome yakakura zvakanyanya, izvo zvinoratidza mhirizhonga yezvirwere izvi.
Zvirwere zveMitochondrial zvinoratidzwa nemifananidzo yakaoma kwazvo yemajini uye yekiriniki, inomiririra musanganiswa weakasiyana-siyana emhando dzekuongorora dziripo. Nzira dzenhaka pano dzimwe nguva dzinoteerera uye dzimwe nguva hadziteerere mitemo yaMendel. Mendel akatsanangura maitiro enhaka yehunhu kuburikidza neyakajairwa nyukireya DNA majini. Mikana yekuonekwa kweiyo genetic maitiro kana chirwere chenhaka inoverengerwa zviri nyore pahwaro hwehuwandu hwekufanotaura kwemhedzisiro yekupatsanurwa kwevana mumhando dzakasiyana dzehunhu kuburikidza nekugara nhaka kweimwe yemakopi maviri ejini rimwe chete kubva kune imwe neimwe ye vabereki (somugumisiro, mumwe nomumwe wevana anogamuchira makopi maviri ejini rimwe nerimwe). Muzviitiko apo mitochondrial syndrome inokonzerwa nekukanganisika kwemajini enyukireya, maitiro anowirirana enhaka anotevera mitemo yeMendelian. Zvisinei, kune marudzi maviri emajenomes anoita kuti mitochondria ishande: mitochondrial DNA (inopfuudzwa chete kuburikidza nemutsara waamai) uye nuclear DNA (yakagara nhaka kubva kuvabereki vose). Nekuda kweizvozvo, maitiro enhaka anosiyana kubva kune autosomal inotonga kune autosomal recessive, pamwe nekutapurirana kwaamai kwemajini.
Mamiriro ezvinhu anowedzera kuomeswa nenyaya yekuti kusangana kwakaoma kunoitika pakati pemtDNA nenDNA muchitokisi. Somugumisiro, kuchinja kwemtDNA kwakafanana kunogona kukonzera zviratidzo zvakasiyana zvakasiyana kune vana vehama vanogara mumhuri imwechete (vanogona kunge vane DNA yenyukireya yakasiyana asi vane mtDNA yakafanana), asi kuchinja kunogona kukonzera zviratidzo zvakafanana. Kunyange mapatya ane chirwere chakafanana anogona kuva nemifananidzo yakasiyana-siyana yekiriniki yechirwere (zviratidzo zvakananga zvinoenderana nekuti ndeapi matissue ari kukanganiswa neiyo pathogenic process), nepo vanhu vane shanduko vanogona kutambura nezviratidzo zvakafanana zvinosangana nemufananidzo wechirwere chimwechete.
Iva sezvazvingave, kune huwandu hukuru hwekusiyana kwemtDNA muzai raamai, uye chokwadi ichi chinokanganisa zvese zvakafanotaurwa nezvemhedzisiro yemararamiro enhaka. Mamiriro eboka iri rezvirwere ane bongozozo zvekuti seti yezviratidzo zvinoenderana nezvirwere izvi inogona kusiyana kubva pamakore gumi kusvika gumi uye inosiyana kunyangwe pakati pehama dzine mitochondrial DNA mutations. Uyezve, dzimwe nguva mitochondrial syndrome inogona kungonyangarika, zvisinei nekuti yaive (kana kuti yaifanira kunge yakagarwa). Asi zviitiko zvinofadza zvakadaro hazviwanzo, uye kazhinji zvirwere zvemitochondrial zvinofambira mberi. Mutafura Tables 2.2 uye 2.3 inopa zvirwere uye zviratidzo zvinosangana nekusashanda kwemitochondrial, pamwe chete nemararamiro ezvirwere izvi. Parizvino, sainzi inoziva anopfuura mazana maviri emhando dzemitochondrial mutations. Tsvagiridzo inoratidza kuti hosha dzakawanda dzinodzikira dzinokonzerwa nemhando idzi dzekuchinja (zvinoreva kuti tinofanira kudzokorora nhamba huru yezvirwere sezvirwere zvemitochondrial).
Sezvatinoziva, shanduko idzi dzinogona kuita kuti mitochondria imire kugadzira simba, izvo zvinogona kuita kuti maseru avhare kana kufa. Masero ose (kunze kwemasero matsvuku eropa) ane mitochondria, uye, maererano, mitochondrial syndrome inokanganisa maitiro akawanda uye akasiyana zvikuru emuviri (pamwe chete kana kuti sequentially).
Tafura 2.2. Zviratidzo, zviratidzo uye zvirwere zvinokonzerwa nemitochondrial dysfunction
Tafura 2.3. Congenital zvirwere zvinokonzerwa nekusashanda kwemitochondrial
Zvechokwadi, dzimwe nhengo kana matishu anoda simba kupfuura mamwe. Apo simba rinoda yeimwe nhengo haigoni kugutsikana zvakakwana, zviratidzo zvemitochondrial syndrome zvinotanga kuonekwa. Chekutanga pane zvese, zvinokanganisa mashandiro ehuropi, tsinga, tsandanyama, moyo, itsvo uye endocrine system, kureva, nhengo dzese dzinoda huwandu hwesimba rekuita zvakajairika.
Zvirwere zvakawanikwa zvinokonzerwa nekusashanda kwemitochondrial
Sezvo manzwisisiro edu ekushanda kwemitochondrial uye kusashanda zvakanaka kuri kukura, tave kutanga kugadzira rondedzero refu yezvirwere zvinokonzerwa nekusashanda zvakanaka kwemitochondrial uye kujekesa nzira dzinomuka nezvirwere izvi. Zvimwe zvidzidzo zvenguva pfupi yapfuura zvinoratidza kuti mitochondrial syndrome inobata vanhu vose ve2500. Zvisinei, kana iwe ukanyatsodzidza rondedzero iri pasi apa, unobvumirana kuti nehupamhi hwepamusoro, zvirwere zvemitochondrial (kuberekwa kana kuwanikwa) zvichakurumidza kunyorwa mumakumi maviri neshanu kana kunyange chegumi chega chega mugari wenyika dzekuMadokero.
- Type II chirwere cheshuga
- Zvirwere zvegomarara
- Chirwere cheAlzheimer
- Chirwere cheParkinson
- Bipolar affective disorder
- Schizophrenia
- Kuchembera uye kuderera
- Kunetseka kusagadzikana
- Kwete-doro steatohepatitis
- Chirwere chemoyo
- Sarcopenia (kurasikirwa kwemasuru uye simba)
- Dzidzira kusashivirira
- Kuneta, kusanganisira kusingaperi kuneta kwechirwere, fibromyalgia uye myofascial kurwadziwa
Padanho re genetic, maitiro akaomarara akabatana nezvose izvi. Simba rine simba remumwe munhu rinogona kugadziriswa nekuongorora zvirwere zvekuzvarwa kweDNA yake mitochondrial. Asi ichi chingori pokutanga. Nokufamba kwenguva, zvakawanikwa mtDNA zvirema zvinoungana mumuviri, uye mushure mekunge imwe kana imwe nhengo yayambuka imwe chikumbaridzo, inotanga kuita kana kukonzeresa kuderera (nhengo imwe neimwe ine chikumbaridzo chayo chekushivirira, chatichataura nezvacho zvakadzama. )
Rimwe dambudziko nderekuti mitochondrion yega yega ine makopi anosvika gumi emtDNA, uye sero rega, matishu ese, uye nhengo yese ine mitochondria yakawanda. Izvi zvinotevera kuti kune zvisingaverengeki kukanganisa mu mtDNA makopi mumuviri wedu. Kusashanda zvakanaka kweimwe nhengo kunotanga apo chikamu chemitochondria yakakanganisika inogara mairi inodarika imwe kukosha. Chiitiko ichi chinodaidzwa kuti threshold effect36. Nhengo imwe neimwe uye matishu inoenderana nekuchinja kwakananga uye inoratidzirwa neyayo shanduko chikumbaridzo, simba rinodiwa uye kuramba kune emahara radicals. Iko kusanganiswa kwezvinhu izvi kunotaridza kuti chii chaizvo chinoitwa nehupenyu hwehupenyu kune genetic kusagadzikana.
Kana chete 10% yemitochondria isina kukwana, iyo 90% yakasara yakajairika majenareta emagetsi emagetsi anogona kutsiva kusashanda kwe "vaanoshanda navo". Kana, semuenzaniso, kana shanduko isina kunyanyisa asi ichikanganisa nhamba yakakura ye mitochondria, sero rinogona kuramba richishanda zvakajairika.
Kune zvakare pfungwa yekupatsanurwa kweinoremara mitochondria: kana sero rikakamurwa, mitochondria yaro inogovaniswa zvisina tsarukano pakati pevanasikana vaviri masero. Imwe yemasero aya inogona kugamuchira mitochondria yose yakashandurwa, asi imwe yacho inogona kuwana yose yakazara "simba remiti" (zvechokwadi, sarudzo dzepakati dzinonyanya kuitika). Masero ane mitochondria isingashande achafa kuburikidza neapoptosis, nepo masero ane hutano acharamba achiita basa rawo (imwe tsananguro yekunyangarika kamwe kamwe uye kusingatarisirwe kwemitochondrial syndrome). Chiitiko chekusiyana kweDNA sequence ye mitochondria (kana plastids) mumunhu mumwe chete, kazhinji kunyange musero rimwe chete, apo imwe mitochondria, semuenzaniso, inogona kunge iine imwe pathological mutation, asi vamwe vasina, inonzi heteroplasmy. Dhigirii yeheteroplasmy inosiyana kunyangwe pakati pemitezo yemhuri imwechete. Uyezve, chiyero cheheteroplasmy chinogona kusiyanisa kunyange mukati mehupenyu humwe zvichienderana nenhengo chaiyo kana sero, izvo zvinotungamirira kune zvakasiyana-siyana zvekuratidzwa uye zviratidzo zveimwe chirwere chemitochondrial.
Mumuviri we "embryo" inokura, masero paanopatsanurana, mitochondria ine shanduko inozadza nhengo uye matishu anosiyana kubva kune mumwe nemumwe maererano nezvinodiwa zvesimba. Uye kana mutated mitochondria inogara mumasero muhuwandu, izvo zvinozopedzisira zvashanduka kuita metabolically inoshanda zvimiro (semuenzaniso, uropi kana moyo), zvino chipenyu chinowirirana chinozove nematambudziko nehupenyu hwehupenyu (kana huchigoneka zvachose). Kune rimwe divi, kana huwandu hwemitochondria isingashande yakaungana zvakanyanya mumaseru ane mwero wakaderera wemetabolism (titi, mumaseru eganda anogara achitsivana), ipapo mutakuri wemitochondria yakadai angasaziva nezve genetic predisposition kune mitochondrial syndrome. Muchikamu cheThe Bachelor chataurwa pamusoro apa, mumwe wevasikana vane chirwere chemitochondrial aiita seakajairika, nepo mumwe wacho airwara nechirwere chakakomba.
Dzimwe shanduko dzemitochondrial dzinokura zvega nezera semhedzisiro yekugadzirwa kwemahara radicals panguva yakajairika metabolism. Chii chinoitika chinotevera chinoenderana nezvakati wandei. Semuyenzaniso, kana sero rakazadzwa nemitochondria isingashande rakapatsanuka nekumhanya kukuru, sezvinoita maseru etsinde anoita basa rekuvandudza matishu, ipapo majenareta esimba akaremara anozoita nekushingaira kuwedzera kwawo. Kana iyo sero isina simba isingachapatsanuri (ngatifungidzire kuti tiri kutaura nezve neuron), ipapo shanduko dzicharamba dziri mukati mesero iri chete, iro, zvisinei, risingabvisi mukana wekubudirira kwekuchinja. Nokudaro, ndiko kuoma kweiyo genetic nheyo ye mitochondrial syndrome inotsanangura chokwadi chokuti kupera kwezvinhu zvebioenergetic zvemuviri, zvinokonzerwa nekuchinja kwemitochondrial, zvinozviratidza mukati mehuwandu hwezvirwere zvakasiyana-siyana uye zvakaoma uye zviratidzo.
Tinofanirawo kuyeuka kuti kune majini akawanda kunze kwemtDNA ane basa rekuita kwese mitochondria. Kana shanduko ikakanganisa majini encoding RNA, mhedzisiro yacho inowanzova yakakomba. Muzviitiko apo mwana anogamuchira mutated mitochondrial transcription factor pakubata kwake pamuviri kubva kune mumwe mubereki (yeuka kuti zvinyorwa zvinyorwa mapuroteni anodzora hurongwa hwemRNA synthesis paDNA matrix nekusunga kune zvimwe zvikamu zveDNA), ipapo mitochondria yake yose ichave. kuve pachena kune pathogenic mhedzisiro. Nekudaro, kana shanduko iine chekuita chete kune chaiyo yakanyorwa zvinhu izvo zvinongoitwa mune dzimwe nhengo kana matishu kana mukupindura kuburitswa kweimwe hormone, ipapo inoenderana pathogenic mhedzisiro inove yenzvimbo chete.
Izvo zvakasiyana-siyana zvezvirwere zvemitochondrial uye kuratidzwa kwavo idambudziko rakakomba kune vanachiremba (zvose zvinyorwa uye zvinoshanda), kusanganisira kusakwanisa kwekufanotaura kukura kwemitochondrial syndrome. Kune zvirwere zvemitochondrial zvakawanda zvekuti zvakaoma kungozvitumidza zvese, uye mazhinji acho haasati awanikwa. Kunyange nhamba yezvirwere zvinonyanya kuzivikanwa (zvirwere zvemwoyo, kenza, mamwe maitiro ekuora mwoyo, nezvimwewo) zvinonzi nesayenzi yemazuva ano kune mitochondrial dysfunction.
Zvakakosha kuziva kuti kunyange zvazvo pasina mushonga wezvirwere zvemitochondrial, vanhu vakawanda vane mamiriro ezvinhu aya (kunyanya avo vane chirwere chinyoro kana chepakati) vanogona kurarama hupenyu hurefu, hune hutano. Zvisinei, nokuda kweizvi tinofanira kushanda zvakarongeka, tichishandisa ruzivo rwakaonekwa rwatinarwo.
Nezvomunyori
Lee Ziva ndichiremba ane rezinesi naturopathic anobva kuCanada, anohwina mibairo yakati wandei. Vaanoshanda navo vanomuziva semuoni muzvinabhizimusi, strategist uye chiremba. Lee akabata zvinzvimbo semuongorori wezvekurapa, nyanzvi yesainzi, uye director wezvekutsvagisa nekusimudzira kumasangano makuru. Pamusoro pebasa resainzi rekambani yake, anovewo chipangamazano muminda yezvigadzirwa zvehutano zvakasikwa uye zvekudya zvinowedzera, uye anoshanda padhipatimendi rekupa mazano reAlive magazine, magazini yeCanada inoverengwa zvakanyanya. Anodaidza Greater Toronto Area musha, kwaanogara nemukadzi wake nevanakomana vavo vaviri, uye anonyanya kufarira kusimudzira hutano hwepanyama uye zvakatipoteredza.
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Source: www.habr.com