Muzhizha re2018, chikoro chezhizha chegore negore mu bioinformatics chakaitwa pedyo neSt.
Chakanyanya kutariswa pachikoro ichi chaive pakutsvagisa cancer, asi kwaive nehurukuro kune dzimwe nzvimbo dzebioinformatics, kubva pakushanduka-shanduka kusvika pakuongorora kwesero-sero rekuteedzera data. Mukufamba kwesvondo, vakomana vakadzidza kushanda nezera rinotevera rekuteedzera data, rakarongwa muPython neR, vakashandisa zvakajairwa bioinformatics maturusi nemafuremu, vakajairana nenzira dzemasystem biology, genetics yehuwandu uye kutevedzera zvinodhaka pakudzidza mamota, nezvimwe zvakawanda.
Pazasi unowana vhidhiyo yehurukuro gumi nesere dzakapihwa pachikoro, ine tsananguro pfupi nemasiraidhi. Ayo akanyorwa nenyeredzi β*β akakosha uye anogona kutariswa pasina kugadzirira.
1*. Oncogenomics uye yakasarudzika oncology | Mikhail Pyatnitsky, Research Institute yeBiomedical Chemistry
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Mikhail akataura muchidimbu nezve tumor genomics uye nekunzwisisa kushanduka kwekenza maseru kunotibvumira kugadzirisa matambudziko anoshanda mune oncology. Mudzidzisi akatarisisa kutsanangura mutsauko uripo pakati peoncogenes uye tumor suppressors, nzira dzekutsvaga "gomarara regomarara" uye kuona mamolecular subtypes emamota. Mukupedzisa, Mikhail akateerera kune ramangwana re oncogenomics uye matambudziko angamuka.
2*. Genetic kuongororwa kwenhaka tumor syndromes | Andrey Afanasyev, yRisk
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Andrey akataura nezve hereditary bundu syndromes uye akakurukura biology yavo, epidemiology uye kuratidzwa kwekiriniki. Chikamu chehurukuro yakazvipira kunyaya yekuongororwa kwemajini - ndiani anofanirwa kuipfuura, chii chinoitirwa izvi, ndeapi matambudziko anomuka mukugadzirisa data nekududzira mhedzisiro, uye, pakupedzisira, zvikomborero zvipi zvinounza kuvarwere nehama dzavo. .
3*. Iyo Pan-Cancer Atlas | German Demidov, BIST/UPF
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Pasinei nemakumi emakore ekutsvakurudza mumunda wekenza genomics uye epigenomics, mhinduro kumubvunzo wekuti "sei, kupi uye nei tumarara syndromes inomuka" haisati yakwana. Chimwe chikonzero cheizvi kudiwa kwekutorwa kwakamisikidzwa uye kugadzirisa huwandu hukuru hwedata kuitira kuti uone mhedzisiro yehukuru hudiki hunonetsa kuona mune shoma data seti (saizi inofananidzwa nechidzidzo mukati meimwe kana akati wandei marabhoritari) , asi iyo muunganidzwa inoita basa rakakura basa rakakura muchirwere chakaomarara uye chakawanda sekenza.
Mumakore mashoma apfuura, mazhinji emapoka etsvakurudzo ane simba zvikuru enyika, achiziva nezvedambudziko iri, akatanga kubatana mukuedza kuona nekutsanangura zvose izvi. Herman akataura nezvechimwe chezvirongwa izvi (Iyo PanCancer Atlas) uye mhedzisiro yakawanikwa sechikamu chebasa remubatanidzwa uyu wemarabhoritari uye yakaburitswa mune yakakosha chinyorwa cheSero muhurukuro iyi.
4. ChIP-Seq mukudzidza epigenetic nzira | Oleg Shpynov, JetBrains Tsvakurudzo
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Kudzora kwekutaura kwejeni kunoitwa nenzira dzakasiyana. Pahurukuro yake, Oleg akataura nezve epigenetic regulation kuburikidza ne histone modification, chidzidzo chemaitiro aya uchishandisa nzira yeChIP-seq uye nzira dzekuongorora migumisiro yakawanikwa.
5. Multiomics muCancer Research | Konstantin Okonechnikov, German Cancer Research Center
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Kuvandudzwa kwetekinoroji yekuyedza mumolecular biology kwaita kuti zvikwanise kusanganisa kudzidza kweakasiyana maitiro anoshanda mumaseru, nhengo kana kunyange chipenyu chose. Kugadzira hukama pakati pezvikamu zvebiological process, zvinodikanwa kushandisa multiomics, iyo inosanganisa yakakura yekuyedza data kubva kugenomics, transcriptomics, epigenomics uye proteomics. Konstantin akapa mienzaniso yakajeka yekushandiswa kwema-multi-omics mumunda wekutsvaga kenza nekutarisa pavana oncology.
6. Kusiyana-siyana uye Kugumira kweSingle Cell Analysis | Konstantin Okonechnikov
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Hurukuro yakadzama pane imwechete-sero RNA-seq uye nzira dzekuongorora iyi data, pamwe nenzira dzekukunda matambudziko ari pachena uye akavanzika paunenge uchiadzidza.
7. Kuongororwa kwe-single-cell RNA-seq data | Konstantin Zaitsev, Washington University muSt
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Nhanganyaya pamusoro pekutevedzana kwesero rimwe chete. Konstantin anokurukura nzira dzekutevedzana, kuomerwa nebasa remurabhoritari uye kuongorora bioinformatics, uye nzira dzekuzvikunda.
8. Kuongororwa kwetsandanyama dystrophy uchishandisa nanopore sequencing | Pavel Avdeev, George Washington University
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Sequencing uchishandisa Oxford Nanopore tekinoroji ine zvakanakira zvinogona kushandiswa kuona genetic zvikonzero zvezvirwere zvakaita semuscular dystrophy. Muhurukuro yake, Pavel akataura nezvekugadzirwa kwepombi yekuongorora chirwere ichi.
9*. Girafu inomiririra iyo genome | Ilya Minkin, Pennsylvania State University
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Magirafu mamodheru anobvumira compact kumiririra kwenhamba huru yeakatevedzana akafanana uye anowanzoshandiswa mune genomics. Ilya akataura zvakadzama nezvekuti genomic sequences inovakwa sei vachishandisa magirafu, sei uye nei iyo de Bruin graph inoshandiswa, yakawanda sei iyo "graph" nzira inowedzera kururamisa kwekutsvaga kwekuchinja, uye ndeapi matambudziko asina kugadziriswa nekushandiswa kwemagirafu achiripo.
10*. Inovaraidza proteinomics | Pavel Sinitsyn, Max Planck Institute yeBiochemistry (zvikamu zviviri)
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Mapuroteni ane mutoro weakawanda biochemical maitiro muchinhu chipenyu, uye kusvika zvino maproteomics ndiyo chete nzira yekuongorora kwepasirese mamiriro ezviuru zvemapuroteni panguva imwe chete. Huwandu hwematambudziko akagadziriswa hunokatyamadza - kubva pakuziva masoja ekudzivirira chirwere uye maantigen kusvika pakuona kuwanikwa kwezviuru zvemapuroteni. Muhurukuro dzake, Pavel akataura pamusoro peizvi uye zvimwe zvinoshandiswa zveproteomics, kukura kwayo uye zvipingamupinyi mukuongororwa kwedata.
gumi neimwe*. Nheyo dzekutanga dzema molecular simulations | Pavel Yakovlev, BIOCAD
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Introductory theoretical lecture pamusoro pemamolecular dynamics: sei ichidikanwa, chii chaanoita uye kuti chinoshandiswa sei maererano nekugadzirwa kwezvinodhaka. Pavel akatarisisa nzira dzemamorekuru dynamics, tsananguro yemasimba masimba, tsananguro yekubatanidza, pfungwa dze "force field" uye "kubatanidzwa", zvipimo mukuenzanisira, nezvimwe zvakawanda.
12*. Molecular Biology uye Genetics | Yuri Barbitov, Institute of Bioinformatics
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Nhanganyaya yezvikamu zvitatu kune molecular biology uye genetics yevadzidzi veinjiniya nevakapedza kudzidza. Hurukuro yekutanga inokurukura pfungwa dzemazuva ano biology, nyaya dze genome chimiro uye kuitika kwekuchinja. Chechipiri chinobata zvakadzama nyaya dzekushanda kwemajini, maitiro ekunyora nekushandura, chechitatu chinobata kudzorwa kwekutaura kwemajini uye nzira dzekutanga dzemamolekyulu ebhayoloji.
13*. Nheyo dzeNGS Data Analysis | Yuri Barbitov, Institute of Bioinformatics
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Hurukuro iyi inotsanangura nzira dzechizvarwa chechipiri (NGS), mhando dzadzo uye maitiro. Mudzidzisi anotsanangura zvakadzama kuti data "yakabuda" kubva kune sequencer yakagadziriswa sei, kuti inoshandurwa sei kuti iongororwe, uye ndedzipi nzira dzekushanda nayo.
14*. Uchishandisa mutsara wekuraira, dzidzira | Gennady Zakharov, EPAM
Pfupiso inoshanda yemirairo inobatsira mumutsara wemirairo Linux, sarudzo, uye zvekutanga zvekushandiswa kwazvo. Mienzaniso yakatarisana nekuongorora maDNA akatevedzana. Pamusoro pekushanda kwakajairika Linux (semuenzaniso, cat, grep, sed, awk) zvishandiso zvekushanda nematanho (samtools, bedtools) zvinofungwa nezvazvo.
15*. Kuona data kwevadiki | Nikita Alekseev, ITMO University
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Wese munhu akave neruzivo rwekuenzanisira mhedzisiro yemapurojekiti avo esainzi kana kunzwisisa madhayagiramu evamwe vanhu, magirafu nemifananidzo. Nikita akaudza nzira yekududzira zvakarurama magirafu nemifananidzo, achisimbisa chinhu chikuru kubva kwavari; kudhirowa mifananidzo yakajeka. Mudzidzisi akasimbisawo zvekutarisa kana uchiverenga chinyorwa kana kuona kushambadzira.
16*. Mabasa muBioinformatics | Victoria Korzhova, Max Planck Institute yeBiochemistry
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Victoria akataura nezve chimiro chesainzi yedzidzo kunze kwenyika uye izvo zvaunoda kutarisisa kuti uvake basa resainzi kana indasitiri sewe undergraduate, akapedza kudzidza kana akapedza kudzidza.
17*. Maitiro ekunyora CV yesainzi | Victoria Korzhova, Max Planck Institute yeBiochemistry
Chii chekusiya muCV uye chii chekubvisa? Ndezvipi zvinhu zvichafadza kune angangove maneja werabhu, uye ndezvipi zviri nani kusataura? Iwe unofanirwa kuronga sei ruzivo kuti resume yako ive pachena? Hurukuro yacho ichapa mhinduro kumibvunzo iyi nemimwe.
18*. Mashandisiro anoita iyo bioinformatics musika | Andrey Afanasyev, yRisk
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Musika unoshanda sei uye angashanda kupi bioinformatics? Mhinduro kumubvunzo uyu inoratidzwa zvakadzama, nemienzaniso nemazano, muhurukuro yaAndrey.
Kuguma
Sezvaungave waona, zvidzidzo zvepachikoro zvakapamhama mumisoro - kubva pakuenzanisira kwemamorekuru uye kushandiswa kwemagirafu ekubatanidza genome, kusvika pakuongorora masero mamwechete uye kuvaka basa resainzi. Isu veInstitute of Bioinformatics tinoedza kusanganisa misoro yakasiyana-siyana muchirongwa chechikoro kuitira kuti tivhare dzidziso dzakawanda dzebioinformatics sezvinobvira, uye kuti mutori wechikamu wega wega adzidze chimwe chinhu chitsva uye chinobatsira.
Chikoro chinotevera chebioinformatics chichaitwa kubva munaChikunguru 29 kusvika Nyamavhuvhu 3, 2019 pedyo neMoscow. . Musoro wegore rino uchave bioinformatics mukuvandudza biology uye kuchembera kutsvaga.
Kune avo vanoda kudzidza bioinformatics zvakadzama, isu tichiri kugamuchira zvikumbiro zvedu muSt. Kana kutevera nhau dzedu pamusoro pekuvhurwa kwechirongwa muMoscow kudonha uku.
Kune avo vasiri muSt. Petersburg kana kuMoscow, asi vanoda chaizvo kuva bioinformatics, takagadzirira mune algorithms, programming, genetics uye biology.
Isu tine gumi nevaviri , iyo yaunogona kutanga kuenda nayo izvozvi.
Muna 2018, chikoro chezhizha mu bioinformatics chakaitwa nerutsigiro rwevatinogara navo - makambani JetBrains, BIOCAD uye EPAM, ayo tinovatenda zvikuru.
Bioinformatics munhu wese!
PS Kana wanga usingafungi kuti zvakwana, ΠΈ .
Source: www.habr.com
