{"id":30803,"date":"2019-10-31T21:37:30","date_gmt":"2019-10-31T18:37:30","guid":{"rendered":"https:\/\/prohoster.info\/blog\/hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk\/"},"modified":"2019-10-31T21:37:30","modified_gmt":"2019-10-31T18:37:30","slug":"hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk","status":"publish","type":"post","link":"https:\/\/prohoster.info\/sq\/blog\/administrirovanie\/hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk","title":{"rendered":"\u00abHello\u00bb! Depozita automatike e par\u00eb n\u00eb bot\u00eb n\u00eb molekulat e ADN-s\u00eb","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\u00abHello\u00bb!
\n<\/p>\n

Ekspert\u00ebt nga Microsoft dhe Universiteti i Washingtonit demonstruan sistemin e par\u00eb t\u00eb automatizuar plot\u00ebsisht p\u00ebr ruajtjen e t\u00eb dh\u00ebnave n\u00eb ADN t\u00eb krijuar m\u00eb q\u00ebllim me mund\u00ebsi leximi. Ky \u00ebsht\u00eb nj\u00eb hap ky\u00e7 n\u00eb drejtim t\u00eb transferimit t\u00eb teknologjis\u00eb s\u00eb re nga laborator\u00ebt hulumtues n\u00eb qendrat komerciale t\u00eb ruajtjes s\u00eb t\u00eb dh\u00ebnave.<\/p>\n

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Zhvilluesit konfirmuan konceptin p\u00ebrmes nj\u00eb testi t\u00eb thjesht\u00eb: koduan me sukses fjal\u00ebn \"hello\" n\u00eb fragmente molekulash sintetike ADN dhe e kthyen at\u00eb s\u00ebrish n\u00eb t\u00eb dh\u00ebna digjitale duke p\u00ebrdorur nj\u00eb sistem plot\u00ebsisht t\u00eb automatizuar, q\u00eb p\u00ebrshkruhet n\u00eb artikullin<\/a><\/noindex>, e publikuar m\u00eb 21 mars n\u00eb Nature Scientific Reports.<\/p>\n

<\/a><\/noindex>
\nKy artikull \u00ebsht\u00eb n\u00eb faqen ton\u00eb.<\/a><\/noindex><\/p>\n

Molekulat e ADN-s\u00eb mund t\u00eb ruajn\u00eb informacion digjital me densitet shum\u00eb t\u00eb lart\u00eb, q\u00eb do t\u00eb thot\u00eb n\u00eb nj\u00eb hap\u00ebsir\u00eb fizike, e cila \u00ebsht\u00eb shum\u00eb m\u00eb e vog\u00ebl se ajo q\u00eb z\u00ebn\u00eb qendrat moderne t\u00eb ruajtjes s\u00eb t\u00eb dh\u00ebnave. Kjo \u00ebsht\u00eb nj\u00eb nga zgjidhjet premtuese p\u00ebr ruajtjen e nj\u00eb sasie t\u00eb madhe t\u00eb dh\u00ebnash q\u00eb bota gjeneron \u00e7do dit\u00eb \u2013 nga regjistrat e biznesit dhe videot me kafsh\u00eb t\u00eb \u00ebmbla deri te skanimet mjek\u00ebsore dhe imazhet nga koha.<\/p>\n

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Microsoft po shqyrton m\u00ebnyra p\u00ebr t\u00eb adresuar hendekun e mundsh\u00ebm midis sasis\u00eb s\u00eb t\u00eb dh\u00ebnave q\u00eb prodhojm\u00eb<\/a><\/noindex> dhe d\u00ebshir\u00ebs son\u00eb p\u00ebr t'i ruajtur ato, dhe aft\u00ebsis\u00eb ton\u00eb p\u00ebr t'i ruajtur. Disa nga k\u00ebto m\u00ebnyra p\u00ebrfshijn\u00eb zhvillimin e algoritmeve dhe teknologjive t\u00eb llogaritjeve molekulare p\u00ebr kodimin e t\u00eb dh\u00ebnave n\u00eb ADN t\u00eb artificiale<\/a><\/noindex>. Kjo do t\u00eb lejonte q\u00eb t\u00eb gjith\u00eb informacioni i ruajtur n\u00eb nj\u00eb qend\u00ebr moderne t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave t\u00eb vendosej n\u00eb nj\u00eb hap\u00ebsir\u00eb, p\u00ebraf\u00ebrsisht sa madh\u00ebsia e disa zarave t\u00eb loj\u00ebs.<\/p>\n

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\u00abQ\u00ebllimi yn\u00eb kryesor \u00ebsht\u00eb t\u00eb nxjerrim n\u00eb pun\u00eb nj\u00eb sistem q\u00eb p\u00ebr p\u00ebrdoruesin e fundit do t\u00eb duket pothuajse si \u00e7do sistem tjet\u00ebr i ruajtjes n\u00eb cloud: informacioni d\u00ebrgohet n\u00eb qendr\u00ebn e p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave dhe ruhet atje, dhe m\u00eb pas thjesht shfaqet kur i nevojitet klientit,\u00bb thot\u00eb studiuesja e lart\u00eb e Microsoft, Karin Strauss. \u00abP\u00ebr k\u00ebt\u00eb, na duhej t\u00eb d\u00ebmtonim se ka kuptim praktik nga perspektiva e automatizimit\u00bb.<\/p>\n

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Informacioni ruhet n\u00eb molekulat sintetike t\u00eb ADN-s\u00eb, t\u00eb krijuara n\u00eb laborator, dhe jo n\u00eb ADN-n\u00eb e njer\u00ebzve ose krijesave t\u00eb tjera t\u00eb gjalla, dhe mund t\u00eb kodifikohet para se t\u00eb d\u00ebrgohet n\u00eb sistem. Megjith\u00ebse makinat komplekse, si sintetizuesit dhe sekvencer\u00ebt, tashm\u00eb kryejn\u00eb pjes\u00ebt ky\u00e7e t\u00eb procesit, shum\u00eb nga hapat nd\u00ebrmjet vazhdojn\u00eb t\u00eb k\u00ebrkojn\u00eb pun\u00eb manuale n\u00eb laborator\u00ebt k\u00ebrkimor\u00eb. \"Ky nuk \u00ebsht\u00eb i p\u00ebrshtatsh\u00ebm p\u00ebr p\u00ebrdorim komercial\", tha Kris Takahashi, studiues i lart\u00eb n\u00eb Shkoll\u00ebn e Informatik\u00ebs dhe Inxhinieris\u00eb Paul G. Allen n\u00eb Universitetin e Shteteve t\u00eb Bashkuara.Paul G. Allen School of Computer Science & Engineering<\/a><\/noindex>).<\/p>\n

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\"Njer\u00ebzit me pipetat nuk mund t\u00eb vrapojn\u00eb p\u00ebrmes qendrave t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave, me k\u00ebt\u00eb qasje ka shum\u00eb mund\u00ebsi p\u00ebr gabim njer\u00ebzor, \u00ebsht\u00eb shum\u00eb e shtrenjt\u00eb dhe k\u00ebrkon shum\u00eb hap\u00ebsir\u00eb\", shpjegoi Takahashi.<\/p>\n

\n

\r\n \"Luaj\r\n
<\/div>\r\n <\/div><\/center><\/p>\n

P\u00ebr q\u00eb ky metod\u00eb e ruajtjes s\u00eb t\u00eb dh\u00ebnave t\u00eb ket\u00eb kuptim nga pik\u00ebpamja commerciale, \u00ebsht\u00eb e nevojshme t\u00eb reduktohen kostot si p\u00ebr sintez\u00ebn e ADN-s\u00eb - krijimin e blloqeve themelore nd\u00ebrtimore me sekuenca t\u00eb r\u00ebnd\u00ebsishme, ashtu edhe p\u00ebr procesin e sekvencimit, i cili \u00ebsht\u00eb i nevojsh\u00ebm p\u00ebr t\u00eb lexuar informacionin e ruajtur. Studiuesit thon\u00eb se n\u00eb k\u00ebt\u00eb drejtim po ndodh nj\u00eb zhvillim t\u00eb shpejt\u00eb<\/a><\/noindex>.<\/p>\n

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Sipas studiuesve nga Microsoft, automatizimi \u00ebsht\u00eb nj\u00eb pjes\u00eb tjet\u00ebr ky\u00e7e e k\u00ebtij enigme, q\u00eb lejon organizimin e ruajtjes s\u00eb t\u00eb dh\u00ebnave n\u00eb shkall\u00eb komerciale dhe e b\u00ebn at\u00eb m\u00eb t\u00eb arritsh\u00ebm.<\/p>\n

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N\u00eb p\u00ebrputhje me disa kushte, ADN-ja mund t\u00eb ekzistoj\u00eb shum\u00eb m\u00eb gjat\u00eb se mjetet aktuale t\u00eb ruajtjes arkivuese, t\u00eb cilat shkat\u00ebrrohen brenda disa dekadash. Disa ADN ka arritur t\u00eb ruhet n\u00eb kushte jo ideale p\u00ebr disa dhjet\u00ebra mij\u00ebra vjet - n\u00eb d\u00ebrrasat e mamut\u00ebve dhe n\u00eb kockat e njer\u00ebzve t\u00eb hersh\u00ebm. Pra, t\u00eb dh\u00ebnat mund t\u00eb ruhen n\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb, sa koh\u00eb q\u00eb ekziston njer\u00ebzimi.<\/p>\n

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Sistemi automatizuar i ruajtjes s\u00eb t\u00eb dh\u00ebnave t\u00eb ADN-s\u00eb p\u00ebrdor nj\u00eb program t\u00eb zhvilluar nga ekspert\u00ebt e Microsoft dhe Universitetit t\u00eb Washingtonit (UW). Ai kthen bitet e t\u00eb dh\u00ebnave digjitale n\u00eb sekuenca nukleotidesh (A, T, C dhe G), q\u00eb p\u00ebrfaq\u00ebsojn\u00eb \"nd\u00ebrtesat\" e ADN-s\u00eb. Pas k\u00ebsaj, sistemi p\u00ebrdor pajisje laboratorike standarde dhe t\u00eb p\u00ebrballueshme p\u00ebr t\u00eb d\u00ebrguar l\u00ebngjet dhe reagens\u00ebt e nevojsh\u00ebm n\u00eb nj\u00eb sintetizues q\u00eb zusammelon fragmentet e ADN-s\u00eb dhe i vendos ato n\u00eb nj\u00eb depo t\u00eb ruajtjes.<\/p>\n

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Kur sistemi ka nevoj\u00eb t\u00eb nxjerr\u00eb informacion, ai shton p\u00ebrb\u00ebr\u00ebs t\u00eb tjer\u00eb kimik p\u00ebr t\u00eb p\u00ebrgatitur ADN-n\u00eb q\u00eb t\u00eb jet\u00eb e duhur dhe p\u00ebrdor pompat mikrofluide p\u00ebr t\u00eb shtyr\u00eb l\u00ebngjet n\u00eb pjes\u00ebt e sistemit q\u00eb lexojn\u00eb sekuencat e molekulave t\u00eb ADN-s\u00eb dhe i kthejn\u00eb ato p\u00ebrs\u00ebri n\u00eb informacion t\u00eb kuptuesh\u00ebm p\u00ebr kompjuterin. K\u00ebrkuesit thon\u00eb se q\u00ebllimi i projektit nuk ishte t\u00eb provohej q\u00eb sistemi mund t\u00eb punonte shpejt ose me kosto t\u00eb ul\u00ebt, por thjesht p\u00ebr t\u00eb treguar se automatizimi \u00ebsht\u00eb i mundur.<\/p>\n

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Nj\u00eb nga p\u00ebrfitimet m\u00eb t\u00eb dukshme t\u00eb nj\u00eb sistemi t\u00eb automatizuar t\u00eb ruajtjes s\u00eb ADN-s\u00eb \u00ebsht\u00eb se ai u jep shkenc\u00ebtar\u00ebve mund\u00ebsin\u00eb t\u00eb merren me challenges m\u00eb komplekse, duke i liruar ata nga k\u00ebrkimi i shisheve me reaktant\u00eb ose nga shtimi monoton i pika t\u00eb l\u00ebngshme n\u00eb tubat e testimit.<\/p>\n

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\u00abPrania e nj\u00eb sistemi t\u00eb automatizuar p\u00ebr kryerjen e pun\u00ebve p\u00ebrs\u00ebrit\u00ebse lejon q\u00eb punonj\u00ebsit e laborator\u00ebve t\u00eb p\u00ebrqendrohen direkt n\u00eb hulumtime, t\u00eb zhvillojn\u00eb strategji t\u00eb reja p\u00ebr t\u00eb implementuar inovacione m\u00eb shpejt\u00bb, tha k\u00ebrkuesi nga Microsoft, Bihlin Nguyen.<\/p>\n

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Ekipi nga Laboratori i Sistemeve Informuese Molekulare Molecular Information Systems Lab<\/a><\/noindex> (MISL) ka treguar tashm\u00eb se mund t\u00eb ruaj\u00eb fotografit\u00eb e koteleve, vepra t\u00eb shk\u00eblqyera letrare, video<\/a><\/noindex> dhe regjistrime arkivore n\u00eb ADN dhe t\u00eb nxjerr\u00eb k\u00ebta skedar\u00eb pa gabime. Deri m\u00eb tani ata kan\u00eb arritur t\u00eb ruajn\u00eb 1 gigabajt t\u00eb dh\u00ebnash n\u00eb ADN, duke thyer rekordin e m\u00ebparsh\u00ebm bot\u00ebror prej 200 Mb<\/a><\/noindex>.<\/p>\n

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K\u00ebrkuesit gjithashtu kan\u00eb zhvilluar metoda p\u00ebr kryerjen e llogaritjeve dometh\u00ebn\u00ebse<\/a><\/noindex>, si si b\u00ebjn\u00eb mund\u00ebsin\u00eb p\u00ebr t\u00eb k\u00ebrkuar dhe nxjerr\u00eb vet\u00ebm imazhe q\u00eb p\u00ebrmbajn\u00eb moll\u00eb ose bi\u00e7iklet\u00eb t\u00eb gjelb\u00ebr, duke p\u00ebrdorur vet\u00eb molekulat, pa e kthyer skedarin p\u00ebrs\u00ebri n\u00eb formatin digjital.<\/p>\n

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\u00ab\u00cbsht\u00eb e sigurt t\u00eb thuhet se po v\u00ebzhgojm\u00eb lindjen e nj\u00eb sistemi t\u00eb ri kompjuterik, ku molekulat p\u00ebrdoren p\u00ebr ruajtjen e t\u00eb dh\u00ebnave dhe elektronika p\u00ebr menaxhim dhe p\u00ebrpunim. Kjo kombinim hap mund\u00ebsi shum\u00eb interesante p\u00ebr t\u00eb ardhmen\u00bb, tha profesori i shkoll\u00ebs Allen n\u00eb Universitetin e Washingtonit. Luis Ceze<\/a><\/noindex>.<\/p>\n

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Ndryshe nga sistemet kompjuterike t\u00eb bazuara n\u00eb komponent\u00eb silikoni, sistemet e ruajtjes dhe p\u00ebrpunimit t\u00eb bazuara n\u00eb ADN duhet t\u00eb p\u00ebrdorin l\u00ebngje p\u00ebr t\u00eb trasladuar molekulat. Por l\u00ebngjet natyrisht dallohen nga elektronet dhe k\u00ebrkojn\u00eb zgjidhje teknike krejt\u00ebsisht t\u00eb reja.<\/p>\n

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Ekipi i Universitetit t\u00eb Washingtonit, n\u00eb bashk\u00ebpunim me Microsoft, po zhvillon gjithashtu nj\u00eb sistem programues q\u00eb automatizon eksperimentet laboratorike, duke p\u00ebrdorur pronat e elektricitetit dhe ujit p\u00ebr t\u00eb zhvendosur pika mbi nj\u00eb rrjet elektrodash. Grupi i plot\u00eb i softuerit dhe harduerit, i njohur si Puddle dhe PurpleDrop<\/a><\/noindex>, mund t\u00eb p\u00ebrziej\u00eb, ndan\u00eb, ngroh\u00eb ose ftoh\u00eb l\u00ebngje t\u00eb ndryshme dhe t\u00eb kryej\u00eb protokollet laboratorike.<\/p>\n

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Q\u00ebllimi \u00ebsht\u00eb t\u00eb automatizohen eksperimentet laboratorike q\u00eb aktualisht po kryhen me dor\u00eb ose nga robota t\u00eb shtrenjt\u00eb q\u00eb punojn\u00eb me l\u00ebngje, si dhe t\u00eb reduktohen kostot.<\/p>\n

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Hapat e ardhsh\u00ebm p\u00ebr ekipin MISL p\u00ebrfshijn\u00eb integrimin e nj\u00eb sistemi t\u00eb thjesht\u00eb t\u00eb automatizuar mes qenieve me teknologjit\u00eb si Purple Drop, si dhe me teknologji t\u00eb tjera q\u00eb mund\u00ebsojn\u00eb k\u00ebrkimin n\u00eb molekulat e ADN-s\u00eb. K\u00ebrkuesit e b\u00ebn\u00eb sistemin e tyre automatizuar modulor n\u00eb m\u00ebnyr\u00eb q\u00eb ai t\u00eb mund t\u00eb zhvillohet me kalimin e teknologjive t\u00eb reja p\u00ebr sintez\u00ebn, sekuencimin dhe manipulimin e ADN-s\u00eb.<\/p>\n

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\u00abNj\u00eb nga avantazhet e k\u00ebtij sistemi \u00ebsht\u00eb se n\u00ebse duam t\u00eb z\u00ebvend\u00ebsojm\u00eb nj\u00eb nga pjes\u00ebt me di\u00e7ka t\u00eb re, m\u00eb t\u00eb avancuar ose m\u00eb t\u00eb shpejt\u00eb, ne mund ta lidhim thjesht pjes\u00ebn e re, - tha Nguyen. - Kjo na jep fleksibilitet m\u00eb t\u00eb madh p\u00ebr t\u00eb ardhmen.\u00bb<\/p>\n

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Imazhi i sip\u00ebrm: hulumtuesit nga Microsoft dhe Universitatea e Washingtonit regjistruan dhe lexuan fjal\u00ebn \u00ab<\/em>hello<\/em>\u00bb, duke p\u00ebrdorur sistemin e par\u00eb plot\u00ebsisht t\u00eb automatizuar p\u00ebr ruajtjen e t\u00eb dh\u00ebnave n\u00eb ADN. Ky \u00ebsht\u00eb nj\u00eb hap ky\u00e7 drejt transferimit t\u00eb teknologjis\u00eb s\u00eb re nga laborator\u00ebt n\u00eb qendrat komerciale t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave.<\/em><\/p>\n

Burimi: habr.com<\/a><\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

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