{"id":30803,"date":"2019-10-31T21:37:30","date_gmt":"2019-10-31T18:37:30","guid":{"rendered":"https:\/\/prohoster.info\/blog\/hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk\/"},"modified":"2019-10-31T21:37:30","modified_gmt":"2019-10-31T18:37:30","slug":"hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk","status":"publish","type":"post","link":"https:\/\/prohoster.info\/sq\/blog\/administrirovanie\/hello-pervoe-v-mire-avtomaticheskoe-hranilishhe-dannyh-v-molekulah-dnk","title":{"rendered":"\u00abHello\u00bb! E para magazin\u00eb automatike e t\u00eb dh\u00ebnave n\u00eb molekulat e ADN-s\u00eb n\u00eb bot\u00eb","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\u00abHello\u00bb!
\n<\/p>\n

K\u00ebrkuesit nga Microsoft dhe Universiteti i Washingtonit demonstruan sistemin e par\u00eb t\u00eb plot\u00ebsisht t\u00eb automatizuar p\u00ebr ruajtjen e t\u00eb dh\u00ebnave n\u00eb ADN t\u00eb krijuar n\u00eb m\u00ebnyr\u00eb artificiale me mund\u00ebsi leximi. Ky \u00ebsht\u00eb nj\u00eb hap ky\u00e7 drejt transferimit t\u00eb teknologjis\u00eb s\u00eb re nga laborator\u00ebt e hulumtimit n\u00eb qendrat komerciale t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave.<\/p>\n

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Zhvilluesit konfirmuan konceptin p\u00ebrmes nj\u00eb testi t\u00eb thjesht\u00eb: e koduan me sukses fjal\u00ebn \u00abhello\u00bb n\u00eb fragmente t\u00eb nj\u00eb molekule sintetike ADN dhe e kthyen at\u00eb p\u00ebrs\u00ebri n\u00eb t\u00eb dh\u00ebna dixhitale, duke p\u00ebrdorur nj\u00eb sistem t\u00eb plot\u00eb automatizimi t\u00eb p\u00ebrshkruar n\u00eb artikulli yn\u00eb<\/a><\/noindex>, t\u00eb publikuar m\u00eb 21 mars n\u00eb Nature Scientific Reports.<\/p>\n

<\/a><\/noindex>
\nKy artikull \u00ebsht\u00eb n\u00eb faqen ton\u00eb.<\/a><\/noindex><\/p>\n

N\u00eb molekulat e ADN-s\u00eb mund t\u00eb ruhen t\u00eb dh\u00ebna dixhitale me nj\u00eb densitet shum\u00eb t\u00eb lart\u00eb, dometh\u00ebn\u00eb n\u00eb nj\u00eb hap\u00ebsir\u00eb fizike, e cila \u00ebsht\u00eb shum\u00eb m\u00eb e vog\u00ebl se sa z\u00ebn\u00eb qendrat moderne t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave. Kjo \u00ebsht\u00eb nj\u00eb nga zgjidhjet e premtuara p\u00ebr ruajtjen e sasis\u00eb s\u00eb madhe t\u00eb t\u00eb dh\u00ebnave q\u00eb bota prodhon \u00e7do dit\u00eb, nga rekordet e biznesit dhe videot e kafsh\u00ebve t\u00eb dashura deri tek skanat mjek\u00ebsore dhe imazhet nga hap\u00ebsira.<\/p>\n

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Microsoft po shqyrton m\u00ebnyra p\u00ebr t\u00eb kap\u00ebrcyer dallimin e mundsh\u00ebm midis sasis\u00eb s\u00eb t\u00eb dh\u00ebnave q\u00eb prodhojm\u00eb<\/a><\/noindex> dhe d\u00ebshir\u00ebs ton\u00eb p\u00ebr t'i ruajtur ato, si dhe aft\u00ebsis\u00eb son\u00eb p\u00ebr t'i ruajtur. Nj\u00ebra nga k\u00ebto m\u00ebnyra \u00ebsht\u00eb zhvillimi i algoritmeve dhe teknologjive t\u00eb llogaritjeve molekulare p\u00ebr kodifikimin e t\u00eb dh\u00ebnave n\u00eb ADN artificiale<\/a><\/noindex>. Kjo do t\u00eb mund\u00ebsonte ruajtjen e t\u00eb gjith\u00eb informacionit q\u00eb gjendet n\u00eb nj\u00eb qend\u00ebr moderne t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave n\u00eb nj\u00eb hap\u00ebsir\u00eb, e cila \u00ebsht\u00eb af\u00ebrsisht e barabart\u00eb me madh\u00ebsin\u00eb e disa zarave.<\/p>\n

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\u00abQ\u00ebllimi yn\u00eb kryesor \u00ebsht\u00eb t\u00eb nisemi n\u00eb funksion nj\u00eb sistem i cili p\u00ebr p\u00ebrdoruesin e fundit do t\u00eb duket pothuajse nj\u00ebsoj si \u00e7do sistem tjet\u00ebr ruajtje n\u00eb cloud: informacionet d\u00ebrgohen n\u00eb qendr\u00ebn e p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave dhe ruhen aty, pastaj thjesht shfaqen kur nevojiten nga klienti,\u00bb thot\u00eb hulumtuesja e lart\u00eb e Microsoft, Karin Strauss. \u00abP\u00ebr k\u00ebt\u00eb, na duhej t\u00eb provonim se ka kuptim praktik nga pik\u00ebpamja e automatizimit\u00bb.<\/p>\n

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Informacioni ruhet n\u00eb molekulat sintetike t\u00eb ADN-s\u00eb, t\u00eb krijuara n\u00eb laborator, e jo n\u00eb ADN-n\u00eb e njer\u00ebzve apo krijesave t\u00eb tjera t\u00eb gjalla, dhe mund t\u00eb kodifikohet para se t\u00eb d\u00ebrgohet n\u00eb sistem. Nd\u00ebrsa makinat komplekse, si sintetizator\u00ebt dhe sekvensor\u00ebt, tashm\u00eb kryejn\u00eb pjes\u00eb ky\u00e7e t\u00eb procesit, shum\u00eb nga hapat e nd\u00ebrmjet\u00ebm ende k\u00ebrkojn\u00eb pun\u00eb manuale n\u00eb laboratorin e k\u00ebrkimit. \"Kjo nuk \u00ebsht\u00eb e p\u00ebrshtatshme p\u00ebr p\u00ebrdorim komercial,\" tha Chris Takahashi, shkenc\u00ebtar i lart\u00eb n\u00eb Shkoll\u00ebn e Informatik\u00ebs dhe Inxhinieris\u00eb Paul G. Allen n\u00eb Universitetin e Shteteve t\u00eb Bashkuara.Paul G. Allen School of Computer Science & Engineering<\/a><\/noindex>).<\/p>\n

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\"Njer\u00ebzit nuk mund t\u00eb vrapojn\u00eb me pipetat n\u00eb qendr\u00ebn e p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave, me k\u00ebt\u00eb qasje ka shum\u00eb probabilitet t\u00eb gabimit njer\u00ebzor, \u00ebsht\u00eb shum\u00eb e shtrenjt\u00eb dhe k\u00ebrkon shum\u00eb hap\u00ebsir\u00eb,\" shpjegoi Takahashi.<\/p>\n

\n

\r\n \"Luaj\r\n
<\/div>\r\n <\/div><\/center><\/p>\n

Q\u00eb kjo metod\u00eb e ruajtjes s\u00eb t\u00eb dh\u00ebnave t\u00eb ket\u00eb kuptim nga nj\u00eb pik\u00ebpamje komerciale, \u00ebsht\u00eb e nevojshme q\u00eb t\u00eb ulen kostot si p\u00ebr sintetizimin e ADN-s\u00eb \u2014 krijimin e nd\u00ebrtuesve themelor\u00eb me sekuenca t\u00eb r\u00ebnd\u00ebsishme, ashtu edhe p\u00ebr procesin e sekvenimit, i cili \u00ebsht\u00eb i nevojsh\u00ebm p\u00ebr t\u00eb lexuar informacionin e ruajtur. K\u00ebrkuesit thon\u00eb se n\u00eb k\u00ebt\u00eb drejtim ka nj\u00eb zhvillim t\u00eb shpejt\u00eb. shpejt\u00ebsi t\u00eb madhe<\/a><\/noindex>.<\/p>\n

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Sipas k\u00ebrkuesve nga Microsoft, automatizimi \u00ebsht\u00eb nj\u00eb tjet\u00ebr pjes\u00eb ky\u00e7e e k\u00ebtij enigme, duke mund\u00ebsuar organizimin e ruajtjes s\u00eb t\u00eb dh\u00ebnave n\u00eb nj\u00eb shkall\u00eb komerciale dhe ta b\u00ebj\u00eb at\u00eb m\u00eb t\u00eb arritsh\u00ebm.<\/p>\n

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N\u00ebse p\u00ebrmbahen kushte t\u00eb caktuara, ADN-ja mund t\u00eb ekzistoj\u00eb shum\u00eb m\u00eb gjat\u00eb se mjetet moderne t\u00eb arkivimit q\u00eb shkat\u00ebrrohen brenda disa dekadash. Disa ADN kan\u00eb arritur t\u00eb ruajn\u00eb n\u00eb kushte t\u00eb larg\u00ebta nga idealja p\u00ebr dhjet\u00ebra mij\u00ebra vjet \u2014 n\u00eb brir\u00ebt e mamuth\u00ebve dhe n\u00eb kockat e njer\u00ebzve t\u00eb hersh\u00ebm. K\u00ebshtu, t\u00eb dh\u00ebnat mund t\u00eb ruhen n\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb derisa njer\u00ebzimi t\u00eb ekzistoj\u00eb.<\/p>\n

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Sistemi automatizuar i ruajtjes s\u00eb t\u00eb dh\u00ebnave ADN p\u00ebrdor softuer t\u00eb zhvilluar nga specialist\u00ebt e Microsoft dhe Universitetit t\u00eb Washingtonit (UW). Ai konverton nj\u00ebsit\u00eb dhe zeros e t\u00eb dh\u00ebnave dixhitale n\u00eb sekuenca nukleotidesh (A, T, C dhe G), t\u00eb cilat p\u00ebrfaq\u00ebsojn\u00eb \"blloqet nd\u00ebrtuese\" t\u00eb ADN-s\u00eb. M\u00eb pas, sistemi p\u00ebrdor pajisje laboratorike t\u00eb lira, kryesisht standarde, p\u00ebr t\u00eb transferuar l\u00ebngjet dhe reagjent\u00ebt e nevojsh\u00ebm n\u00eb nj\u00eb sintetizues, i cili ndan fragmente t\u00eb ADN-s\u00eb t\u00eb prodhuara dhe i vendos ato n\u00eb nj\u00eb kapacitet ruajtjeje.<\/p>\n

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Kur sistemi ka nevoj\u00eb t\u00eb nxjerr\u00eb informacion, ai shton substanca t\u00eb tjera kimike p\u00ebr t\u00eb p\u00ebrgatitur sakt\u00eb ADN-n\u00eb dhe p\u00ebrdor pompa mikroflaido p\u00ebr t\u00eb shtyr\u00eb l\u00ebngjet n\u00eb ato pjes\u00eb t\u00eb sistemit q\u00eb lexojn\u00eb sekuencat e molekulave t\u00eb ADN-s\u00eb dhe i konvertojn\u00eb ato p\u00ebrs\u00ebri n\u00eb informacion t\u00eb kuptuesh\u00ebm p\u00ebr kompjuterin. Studiuesit thon\u00eb se q\u00ebllimi i projektit nuk ishte t\u00eb d\u00ebshmonte se sistemi mund t\u00eb punonte shpejt ose lir\u00eb, por thjesht t\u00eb tregonte se automatizimi \u00ebsht\u00eb i mundur.<\/p>\n

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Nj\u00eb nga p\u00ebrfitimet m\u00eb t\u00eb dukshme t\u00eb sistemit automatizuar t\u00eb ruajtjes s\u00eb ADN-s\u00eb \u00ebsht\u00eb se ai \u00e7liron shkenc\u00ebtar\u00ebt p\u00ebr t\u00eb zgjidhur probleme m\u00eb komplekse, duke u lejuar atyre t\u00eb mos e humbasin koh\u00ebn n\u00eb k\u00ebrkimin e shisheve me reagjent\u00eb ose n\u00eb shtimin monotone t\u00eb pikave t\u00eb l\u00ebngut n\u00eb tubat laboratorik\u00eb.<\/p>\n

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\"Disponimi i nj\u00eb sistemi automatizuar p\u00ebr t\u00eb kryer pun\u00ebt e p\u00ebrs\u00ebritura i lejon punonj\u00ebsve t\u00eb laborator\u00ebve t\u00eb angazhohen drejtp\u00ebrdrejt n\u00eb k\u00ebrkime, t\u00eb zhvillojn\u00eb strategji t\u00eb reja p\u00ebr t\u00eb pasuruar inovacionet m\u00eb shpejt\", tha studiuesi i Microsoftit Bihlin Nguyen.<\/p>\n

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Ekipi nga Laboratori i Sistemeve t\u00eb Informacionit Molekular Molecular Information Systems Lab<\/a><\/noindex> (MISL) tashm\u00eb ka demonstruar se mund t\u00eb ruaj\u00eb fotografi t\u00eb maceve, vepra t\u00eb shk\u00eblqyera letrare, video<\/a><\/noindex> dhe regjistra arkivor\u00eb n\u00eb ADN dhe t\u00eb nxjerr\u00eb k\u00ebto skedar\u00eb pa gabime. Deri m\u00eb tani ata kan\u00eb arritur t\u00eb ruajn\u00eb 1 gigabajt t\u00eb dh\u00ebnash n\u00eb ADN, duke thyer rekordin bot\u00ebror t\u00eb m\u00ebparsh\u00ebm prej 200 Mb<\/a><\/noindex>.<\/p>\n

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Studuesit gjithashtu kan\u00eb zhvilluar metoda p\u00ebr kryerjen e llogaritjeve t\u00eb r\u00ebnd\u00ebsishme<\/a><\/noindex>, si\u00e7 \u00ebsht\u00eb k\u00ebrkimi dhe nxjerrja vet\u00ebm e imazheve q\u00eb p\u00ebrmbajn\u00eb nj\u00eb moll\u00eb ose nj\u00eb bi\u00e7iklet\u00eb t\u00eb gjelb\u00ebr, duke p\u00ebrdorur vet\u00eb molekulat, pa e kthyer skedarin p\u00ebrs\u00ebri n\u00eb formatin dixhital.<\/p>\n

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\u00ab\u00cbsht\u00eb e sigurt t\u00eb thuhet se po v\u00ebrejm\u00eb lindjen e nj\u00eb sistemi kompjuterik t\u00eb ri, ku molekulat p\u00ebrdoren p\u00ebr ruajtjen e t\u00eb dh\u00ebnave dhe elektronika p\u00ebr menaxhimin dhe p\u00ebrpunimin. Kjo kombinim hap mund\u00ebsi shum\u00eb interesante p\u00ebr t\u00eb ardhmen\u00bb, tha profesori i shkoll\u00ebs Allen t\u00eb Universitetit t\u00eb Washingtonit. Luis Seze<\/a><\/noindex>.<\/p>\n

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Ndryshe nga sistemet kompjuterike t\u00eb bazuara n\u00eb komponent\u00eb silikoni, sistemet e ruajtjes dhe llogaritjes t\u00eb bazuara n\u00eb ADN duhet t\u00eb p\u00ebrdorin l\u00ebngje p\u00ebr t\u00eb transportuar molekulat. Por l\u00ebngjet, p\u00ebr natyr\u00ebn e tyre, ndryshojn\u00eb nga elektronet dhe k\u00ebrkojn\u00eb zgjidhje teknike krejt\u00ebsisht t\u00eb reja.<\/p>\n

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Ekipa e Universitetit t\u00eb Washingtonit n\u00eb bashk\u00ebpunim me Microsoft po zhvillon gjithashtu nj\u00eb sistem t\u00eb programuesh\u00ebm, i cili automatizon eksperimentet laboratorike, duke p\u00ebrdorur vetit\u00eb e elektricitetit dhe ujit p\u00ebr t\u00eb l\u00ebvizur pika n\u00eb nj\u00eb rrjet elektrodash. Nj\u00eb gam\u00eb e plot\u00eb e softuer\u00ebve dhe pajisjeve, e njohur si Puddle dhe PurpleDrop<\/a><\/noindex>, mund t\u00eb p\u00ebrziej\u00eb, ndajn\u00eb, ngroh\u00eb ose ftoh\u00eb l\u00ebngje t\u00eb ndryshme dhe t\u00eb zbatoj\u00eb protokollet laboratorike.<\/p>\n

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Q\u00ebllimi \u00ebsht\u00eb t\u00eb automatizohen eksperimentet laboratorike, t\u00eb cilat aktualisht kryhen manualisht ose nga robot\u00eb t\u00eb shtrenjt\u00eb q\u00eb punojn\u00eb me l\u00ebngjet, dhe t\u00eb reduktohen shpenzimet.<\/p>\n

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Hapat e ardhsh\u00ebm p\u00ebr ekipin MISL p\u00ebrfshijn\u00eb integrimin e nj\u00eb sistemi t\u00eb thjesht\u00eb automatizimi me teknologjit\u00eb si Purple Drop, si dhe me teknologji t\u00eb tjera q\u00eb lejojn\u00eb k\u00ebrkimin n\u00eb molekulat e ADN-s\u00eb. K\u00ebrkuesit e kan\u00eb projektuar sistemin e tyre automatizuar si modular, p\u00ebr t\u00eb lejuar zhvillimin e tij nd\u00ebrsa shfaqen teknologji t\u00eb reja p\u00ebr sintez\u00ebn, sekvencimin dhe pun\u00ebn me ADN-n\u00eb.<\/p>\n

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\u00abNj\u00eb nga p\u00ebrfitimet e k\u00ebtij sistemi \u00ebsht\u00eb se n\u00ebse d\u00ebshirojm\u00eb t\u00eb z\u00ebvend\u00ebsojm\u00eb nj\u00eb nga pjes\u00ebt me di\u00e7ka t\u00eb re, m\u00eb t\u00eb avancuar ose m\u00eb t\u00eb shpejt\u00eb, mund t\u00eb thjesht\u00eb lidhemi pjes\u00ebn e re, - tha Nguyen. - Kjo na jep fleksibilitet m\u00eb t\u00eb madh p\u00ebr t\u00eb ardhmen\u00bb.<\/p>\n

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Imazhi i sip\u00ebrm: studiuesit nga Microsoft dhe Universiteti i Washingtonit regjistruan dhe lexuan fjal\u00ebn \u00ab<\/em>hello<\/em>\u00bb, duke p\u00ebrdorur sistemin e par\u00eb t\u00eb plot\u00eb t\u00eb automatizuar p\u00ebr ruajtjen e t\u00eb dh\u00ebnave n\u00eb ADN. Ky \u00ebsht\u00eb nj\u00eb hap ky\u00e7 p\u00ebr transferimin e teknologjis\u00eb s\u00eb re nga laborator\u00ebt n\u00eb qendrat tregtare t\u00eb p\u00ebrpunimit t\u00eb t\u00eb dh\u00ebnave.<\/em><\/p>\n

Burimi: habr.com<\/a><\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

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