{"id":38858,"date":"2019-10-31T22:26:24","date_gmt":"2019-10-31T19:26:24","guid":{"rendered":"https:\/\/prohoster.info\/blog\/do-svadby-zazhivet-proliferatsiya-kletok-i-regenerativnye-sposobnosti-meduz\/"},"modified":"2019-10-31T22:26:24","modified_gmt":"2019-10-31T19:26:24","slug":"do-svadby-zazhivet-proliferatsiya-kletok-i-regenerativnye-sposobnosti-meduz","status":"publish","type":"post","link":"https:\/\/prohoster.info\/sq\/blog\/news\/do-svadby-zazhivet-proliferatsiya-kletok-i-regenerativnye-sposobnosti-meduz","title":{"rendered":"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/283754a183ddc1773497c3269611f497.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<br \/>\n\u00c7far\u00eb kan\u00eb t\u00eb p\u00ebrbashk\u00ebt Wolverine, Deadpool dhe meduza? T\u00eb gjith\u00eb ata kan\u00eb nj\u00eb ve\u00e7ori t\u00eb habitshme - rigjenerimin. Sigurisht, n\u00eb komikse dhe filma, kjo aft\u00ebsi, e p\u00ebrhapur mes nj\u00eb numri t\u00eb kufizuar t\u00eb organizmave t\u00eb gjall\u00eb real\u00eb, \u00ebsht\u00eb pak (dhe ndonj\u00ebher\u00eb shum\u00eb) e ekzagjeruar, megjithat\u00eb ajo mbetet mjaft e v\u00ebrtet\u00eb. Dhe ajo q\u00eb \u00ebsht\u00eb reale, mund t\u00eb shpjegohet, \u00e7far\u00eb vendos\u00ebn t\u00eb b\u00ebjn\u00eb n\u00eb hulumtimin e tyre shkenc\u00ebtar\u00ebt nga Universitete Tohoku (Japoni). Cil\u00ebt procese qelizore n\u00eb trupin e meduz\u00ebs jan\u00eb t\u00eb lidhura me rigjenerimin, si ndodh ky proces dhe cilat super-aft\u00ebsi t\u00eb tjera kan\u00eb k\u00ebto krijesa gjellore? K\u00ebto do t\u2019i tregoj\u00eb raporti i grupit k\u00ebrkimor. Le t\u00eb shkojm\u00eb.<noindex><a rel=\"nofollow\" name=\"habracut\"><\/a><\/noindex><\/p>\n<h3>Baza e k\u00ebrkimit<\/h3>\n<p>\nS\u00eb pari, shkenc\u00ebtar\u00ebt shpjegojn\u00eb pse ata vendos\u00ebn t\u00eb p\u00ebrqendrojn\u00eb v\u00ebmendjen e tyre pik\u00ebrisht te meduzat. Arsyeja \u00ebsht\u00eb se shumica e hulumtimeve n\u00eb biologji kryhen me pjes\u00ebmarrjen e ashtuquajturve organizma model: mice, fluturat e frutave, krimbat, peshqit, etj. Por n\u00eb planetin ton\u00eb jetojn\u00eb miliona lloje, secili prej t\u00eb cil\u00ebve ka aft\u00ebsi unike. Prandaj, nuk mund t\u00eb vler\u00ebsohet plot\u00ebsisht procesi i rigjenerimit celular duke studiuar vet\u00ebm nj\u00eb lloj dhe duke supozuar se mekanizmi i studiuar do t\u00eb jet\u00eb i zakonsh\u00ebm p\u00ebr t\u00eb gjitha organizmat n\u00eb Tok\u00eb. <\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/237bf651cd69f76c4bed60f90b316024.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<br \/>\nP\u00ebrsa i p\u00ebrket meduzave, k\u00ebto krijesa me pamjen e tyre t\u00eb jashtme flasin p\u00ebr unikitetin e tyre, q\u00eb nuk mund t\u00eb mos t\u00ebrheq\u00eb v\u00ebmendjen e shkenc\u00ebtar\u00ebve. Prandaj, para se t\u00eb vazhdoj me diseksionin e hulumtimit, u njoha me personazhin kryesor t\u00eb tij.<\/p>\n<p>Me termin \u00abmeduz\u00eb\u00bb, t\u00eb cilin ne e p\u00ebrdorim p\u00ebr t\u00eb quajtur k\u00ebt\u00eb krijes\u00eb, n\u00eb t\u00eb v\u00ebrtet\u00eb quhet vet\u00ebm nj\u00eb faz\u00eb e ciklit t\u00eb jet\u00ebs s\u00eb lloji t\u00eb trupit <i>Medusozoa<\/i>. K\u00ebto krijesa kan\u00eb marr\u00eb nj\u00eb em\u00ebr t\u00eb pazakont\u00eb p\u00ebr shkak t\u00eb pranishm\u00ebris\u00eb s\u00eb qelizave t\u00eb l\u00ebnd\u00ebve ndjell\u00ebse (cnidocit) n\u00eb trupin e tyre, t\u00eb cilat p\u00ebrdoren p\u00ebr gjueti dhe vet\u00ebmbrojtje. Th\u00ebn\u00eb ndryshe, kur ju kafshon nj\u00eb meduz\u00eb, mund t\u00eb falenderoni p\u00ebr dhembjen dhe vuajtjet pik\u00ebrisht k\u00ebto qeliza.<\/p>\n<p>Cnidocitet p\u00ebrmbajn\u00eb cnidocist - nj\u00eb organel\u00eb brenda-qelizore, p\u00ebrgjegj\u00ebse p\u00ebr efektin \u00abndjell\u00ebs\u00bb. N\u00eb pamje dhe p\u00ebr pasoj\u00eb metod\u00ebn e p\u00ebrdorimit, dallohen disa tipe cnidocit, midis t\u00eb cil\u00ebve mund t\u00eb ve\u00e7ojm\u00eb: <\/p>\n<ul>\n<li>penetrant\u00ebt \u2014 fije me maja t\u00eb mprehura, t\u00eb cilat dep\u00ebrtojn\u00eb n\u00eb trupin e viktim\u00ebs ose t\u00eb sulmuesit, si shpata, duke injektuar neurotoksina;<\/li>\n<li>glutinat\u00ebt \u2014 fije ngjit\u00ebse dhe t\u00eb gjata, t\u00eb cilat ngat\u00ebrojn\u00eb viktim\u00ebn (jo p\u00ebrqafime shum\u00eb t\u00eb k\u00ebndshme); <\/li>\n<li>volvent\u00ebt \u2014 fije t\u00eb shkurtra, n\u00eb t\u00eb cilat viktima mund t\u00eb ngat\u00ebrrohet leht\u00eb.<\/li>\n<\/ul>\n<p>\nKy arm\u00eb i pazakont\u00eb shpjegohet me faktin se meduzat, edhe pse elegante, nuk jan\u00eb krijesa shum\u00eb t\u00eb shpejta. Neurotoksina q\u00eb hyn n\u00eb trupin e prenj\u00ebsit e paralizohen menj\u00ebher\u00eb, duke i dh\u00ebn\u00eb meduzave shum\u00eb koh\u00eb p\u00ebr nj\u00eb pushim drek\u00eb.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/e6c7316641ceb921512d2c02107b2144.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Meduza pas nj\u00eb gjuetie t\u00eb suksesshme.<\/i><\/p>\n<p>P\u00ebrve\u00e7 metod\u00ebs s\u00eb pazakont\u00eb t\u00eb gjuetis\u00eb dhe mbrojtjes, meduzat kan\u00eb nj\u00eb riprodhim gjithashtu shum\u00eb t\u00eb pazakont\u00eb. Meshkujt prodhojn\u00eb spermatozoid\u00eb, nd\u00ebrsa femrat prodhojn\u00eb vez\u00eb, pas bashkimit t\u00eb t\u00eb cilave formohen planulat (larvat), t\u00eb cilat vendosen n\u00eb fund. Pas nj\u00eb kohe, larva rritet n\u00eb polip, nga i cili, kur arrin pjekurin\u00eb e tij, dosido dalin meduzat e reja (n\u00eb fakt ndodhin ndarjet). K\u00ebshtu, ekzistojn\u00eb disa faza t\u00eb ciklit t\u00eb jet\u00ebs, nj\u00ebra nga t\u00eb cilat \u00ebsht\u00eb meduza ose gjenerata meduzoide.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/eecb504757979ba8ef4719fbc374e6dc.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Meduza me flok\u00eb, e njohur gjithashtu si 'flok\u00eb i luanit'.<\/i><\/p>\n<p>N\u00ebse do t'i k\u00ebrkohej meduz\u00ebs me flok\u00eb q\u00eb t\u00eb tregonte se si t\u00eb rriteshin efektiviteti i gjuetis\u00eb, ajo do t\u00eb p\u00ebrgjigjej \u2014 m\u00eb shum\u00eb tentakula. Ajo ka rreth 60 (grupe prej 15 tentakulash n\u00eb \u00e7do cep t\u00eb kupol\u00ebs). P\u00ebrve\u00e7 k\u00ebsaj, ky lloj meduze njihet si m\u00eb i madhi, pasi diametri i kupol\u00ebs mund t\u00eb arrij\u00eb deri n\u00eb 2 metra, dhe tentakulat gjat\u00eb gjuetis\u00eb mund t\u00eb zgjaten deri n\u00eb 20 metra. Mir\u00eb q\u00eb ky lloj nuk e karakterizon \u201chelmi\u201d i ve\u00e7ant\u00eb, prandaj nuk \u00ebsht\u00eb fatal p\u00ebr njeriun. <\/p>\n<p>Meduza e detit, nga ana e saj, do t\u00eb shtonte edhe cil\u00ebsin\u00eb p\u00ebrve\u00e7 numrit. Ky lloj meduze gjithashtu ka 15 tentakla (3 m t\u00eb gjat\u00eb) n\u00eb \u00e7do qoshe t\u00eb kupol\u00ebs, por helmi i saj \u00ebsht\u00eb shum\u00eb m\u00eb i fuqish\u00ebm se ai i kush\u00ebririt t\u00eb saj m\u00eb t\u00eb madh. Mendohet se neurotoksina n\u00eb trupin e meduz\u00ebs s\u00eb detit \u00ebsht\u00eb e mjaftueshme p\u00ebr t\u00eb vrar\u00eb 60 njer\u00ebz brenda 3 minutash. Kjo arm\u00eb e detit jeton n\u00eb zonat bregdetare t\u00eb Australis\u00eb veriore dhe Zeland\u00ebs s\u00eb Re. Sipas t\u00eb dh\u00ebnave nga 1884 deri n\u00eb 1996, 63 njer\u00ebz kan\u00eb vdekur n\u00eb Australi, por k\u00ebto t\u00eb dh\u00ebna mund t\u00eb jen\u00eb t\u00eb pasakta, dhe numri i p\u00ebrballjeve fatale midis nesh dhe meduz\u00ebs s\u00eb detit mund t\u00eb jet\u00eb shum\u00eb m\u00eb i lart\u00eb. Megjithat\u00eb, sipas t\u00eb dh\u00ebnave nga 1991-2004, nga 225 raste, vet\u00ebm 8% e t\u00eb l\u00ebnduarve jan\u00eb hospitalizuar, p\u00ebrfshir\u00eb nj\u00eb rast fatale (nj\u00eb f\u00ebmij\u00eb tre vje\u00e7ar). <\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/4e7495cbea692ea2600dcefccc037aef.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Meduza e detit<\/i><\/p>\n<p>Tani, le t\u00eb kthehemi n\u00eb studimin q\u00eb po shqyrtojm\u00eb sot.<\/p>\n<p>Nga nj\u00eb k\u00ebndv\u00ebshtrim qelizor, procesi m\u00eb i r\u00ebnd\u00ebsish\u00ebm n\u00eb jet\u00ebn e \u00e7do organizmi \u00ebsht\u00eb proliferimi celular - procesi i rritjes s\u00eb indit p\u00ebrmes shumimit t\u00eb qelizave p\u00ebrmes ndarjes. Gjat\u00eb rritjes s\u00eb organizmit, ky proces rregullon rritjen e shum\u00ebs s\u00eb trupit. Kur organizmi \u00ebsht\u00eb plot\u00ebsisht i formuar, qelizat proliferuese rregullojn\u00eb shk\u00ebmbimin fiziologjik t\u00eb qelizave dhe z\u00ebvend\u00ebsimin e t\u00eb d\u00ebmtuarve me t\u00eb rinj.<\/p>\n<p>Klasifikimi i strekuesve, si nj\u00eb grup t\u00eb af\u00ebrt t\u00eb organizmave bilateral\u00eb dhe deg\u00ebve t\u00eb hershme t\u00eb zhvillimit t\u00eb organizmave shum\u00ebqelizor\u00eb, \u00ebsht\u00eb p\u00ebrdorur p\u00ebr studimin e proceseve evolucionare p\u00ebr shum\u00eb vite. Prandaj, strekuesit nuk jan\u00eb p\u00ebrjashtim n\u00eb aspektin e proliferimit. P\u00ebr shembull, gjat\u00eb zhvillimit embrional t\u00eb anemon\u00ebs detare <i>Nematostella vectensis<\/i> proliferimi i qelizave \u00ebsht\u00eb i koordinuar me organizimin e epitelit dhe merr pjes\u00eb n\u00eb zhvillimin e tentakleve.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/19086a982c74e5dec5db8641d75040c2.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Nematostella vectensis<\/i><\/p>\n<p>P\u00ebrve\u00e7 k\u00ebsaj, strekuesit, si\u00e7 e dim\u00eb, jan\u00eb t\u00eb njohur p\u00ebr aft\u00ebsit\u00eb e tyre rigjeneruese. Polip\u00ebt e hidrave (nj\u00eb lloj e natyr\u00ebs s\u00eb ujit t\u00eb \u00ebmb\u00ebl nga klasa hidrozoare) jan\u00eb m\u00eb t\u00eb popullarizuarit p\u00ebr studime tashm\u00eb p\u00ebr qindra vjet. Proliferimi, i aktivizuar nga qelizat n\u00eb vdekje, nxit procesin e rigjenerimit t\u00eb kok\u00ebs bazale t\u00eb hidr\u00ebs. Emri i k\u00ebtij krijes\u00eb sugjeron p\u00ebr nj\u00eb krijes\u00eb mitike, e njohur p\u00ebr rigjenerimin e saj - Hidra Lerneane, q\u00eb Herculesi arriti ta mposhtte.<\/p>\n<p>Megjith\u00ebse aft\u00ebsit\u00eb rigjeneruese u lidh\u00ebn me proliferimin, mbetet e paqart\u00eb se si ndodhin sakt\u00ebsisht k\u00ebto procese qelizore n\u00eb kushte normale n\u00eb faza t\u00eb ndryshme t\u00eb zhvillimit t\u00eb organizmave.<\/p>\n<p>Meduzat, q\u00eb kan\u00eb nj\u00eb cik\u00ebl t\u00eb nd \u0441\u043b\u043e\u0436\u00eb jet\u00ebsor t\u00eb p\u00ebrb\u00ebr\u00eb nga dy faza shumimi (vegetative dhe seksi), sh\u00ebrbejn\u00eb si nj\u00eb model t\u00eb shk\u00eblqyer p\u00ebr studimin e proliferimit. <\/p>\n<p>N\u00eb k\u00ebt\u00eb punim, rolin e subjektit kryesor t\u00eb studimit e ka luajtur meduza e llojit Cladonema pacificum. Ky lloj jeton n\u00eb bregdetet e Japonis\u00eb. Fillimisht, kjo meduz\u00eb ka 9 tentakula kryesore, t\u00eb cilat fillojn\u00eb t\u00eb \u00e7ahen dhe rriten n\u00eb madh\u00ebsi (si t\u00ebr\u00eb trupi) gjat\u00eb zhvillimit n\u00eb individ t\u00eb rritur. Ky karakteristik\u00eb lejon studimin e detajuar t\u00eb t\u00eb gjitha mekanizmave q\u00eb marrin pjes\u00eb n\u00eb k\u00ebt\u00eb proces. <\/p>\n<p>P\u00ebrve\u00e7 <i>Cladonema pacificum<\/i> n\u00eb studim u shqyrtuan gjithashtu edhe lloje t\u00eb tjera meduzash: <i>Cytaeis uchidae <\/i>dhe <i>Rathkea octopunctata<\/i>.<\/p>\n<h3>Rezultatet e studimit<\/h3>\n<p>\nP\u00ebr t\u00eb kuptuar rregullsin\u00eb hap\u00ebsinore t\u00eb proliferimit t\u00eb qelizave n\u00eb meduz\u00ebn Cladonema, shkenc\u00ebtar\u00ebt aplikuan ngjyrosjen me 5-etinil-2'-dezoksiguridin (EdU), e cila markon qelizat n\u00eb <i>faz\u00ebn S*<\/i> ose qelizat q\u00eb tashm\u00eb e kan\u00eb kaluar at\u00eb.<\/p>\n<blockquote><p><b>Faza S*<\/b> \u2014 faza e ciklit qelizor, n\u00eb t\u00eb cil\u00ebn ndodh replikimi i ADN-s\u00eb.<\/p><\/blockquote>\n<p>Duke pasur parasysh se <i>Cladonema<\/i> rritet ndjesh\u00ebm n\u00eb madh\u00ebsi dhe tregon \u00e7arje tentakulash gjat\u00eb zhvillimit (<b>1A<\/b>\u2014<b>1C<\/b>), shp\u00ebrndarja e qelizave proliferuese mund t\u00eb ndryshoj\u00eb gjat\u00eb gjith\u00eb procesit t\u00eb pjekuris\u00eb.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/12306fb29a897579c61cceffeea7f722.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Imazhi Nr. 1: ve\u00e7orit\u00eb e proliferimit celular n\u00eb Cladonema t\u00eb rinj.<\/i><\/p>\n<p>P\u00ebr shkak t\u00eb k\u00ebsaj ve\u00e7orie, u arrit t\u00eb studiohet mekanizmi i proliferimit t\u00eb qelizave si te t\u00eb rinjt\u00eb (dit\u00eb 1), ashtu edhe te meduzat e rritura (dita 45).<\/p>\n<p>Te meduzat e reja, qelizat EdU pozitive u zbuluan n\u00eb num\u00ebr t\u00eb madh n\u00eb t\u00ebr\u00eb trupin, duke p\u00ebrfshir\u00eb kupol\u00ebn, manubrium (organ mb\u00ebshtet\u00ebs i goj\u00ebs tek meduzat) dhe tentakulat, pa marr\u00eb parasysh koh\u00ebn e ekspozimit ndaj EdU (<b>1D<\/b>\u2013<b>1K<\/b> dhe <b>1N<\/b>\u2013<b>1O<\/b>, EdU: 20 \u03bcM (mikromolar) pas 24 or\u00ebsh).<\/p>\n<p>N\u00eb manubrium u gjet nj\u00eb num\u00ebr relativisht i vog\u00ebl i qelizave EdU pozitive (<b>1F<\/b> dhe <b>1G<\/b>), nd\u00ebrsa shp\u00ebrndarja e tyre n\u00eb kupol\u00eb ishte shum\u00eb uniforme, ve\u00e7an\u00ebrisht n\u00eb pjes\u00ebn e jashtme t\u00eb kupol\u00ebs (<i>exumbrella<\/i>, <b>1H<\/b>\u2014<b>1K<\/b>). Tek tentakulat, qelizat EdU pozitive ishin shum\u00eb t\u00eb grumbulluara (<b>1N<\/b>). P\u00ebrdorimi i markerit mitotik (antikorpi PH3) siguroi se qelizat EdU pozitive ishin me t\u00eb v\u00ebrtet\u00eb qeliza proliferuese. Qelizat PH3 pozitive u gjet\u00ebn si n\u00eb kupol\u00eb, ashtu edhe n\u00eb bulbin e tentakulave (<b>1L<\/b> dhe <b>1P<\/b>).<\/p>\n<p>N\u00eb tentakulat, qelizat mitotike u identifikuan kryesisht n\u00eb ektoderm\u00eb (<b>1P<\/b>), nd\u00ebrsa n\u00eb ombrell\u00eb, qelizat n\u00eb proliferim ishin t\u00eb vendosura n\u00eb shtres\u00ebn sip\u00ebrfaq\u00ebsore (<b>1M<\/b>).<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/757520bbe6df822e8df7763407b166a4.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Imazhi #2: ve\u00e7orit\u00eb e proliferimit celular t\u00eb Cladonema t\u00eb rritur.<\/i><\/p>\n<p>Si tek individ\u00ebt e rinj ashtu edhe tek ata t\u00eb rritur, qelizat pozitive EdU u gjet\u00ebn n\u00eb num\u00ebr t\u00eb madh n\u00eb t\u00eb gjith\u00eb trupin. N\u00eb ombrell\u00eb, qelizat pozitive EdU zakonisht ndodheshin m\u00eb shpesh n\u00eb shtres\u00ebn sip\u00ebrfaq\u00ebsore sesa n\u00eb at\u00eb t\u00eb poshtme, e cila \u00ebsht\u00eb n\u00eb p\u00ebrputhje me v\u00ebzhgimet p\u00ebr individ\u00ebt e rinj (<b>2A<\/b>\u2014<b>2D<\/b>).<\/p>\n<p>Nd\u00ebrsa n\u00eb tentakula, situata ishte pak m\u00eb ndryshe. Qelizat pozitive EdU u grumbulluan n\u00eb baz\u00ebn e tentakul\u00ebs (bulbi), ku u zbuluan dy grumbuj n\u00eb t\u00eb dyja an\u00ebt e bulbit (<b>2E<\/b> dhe <b>2F<\/b>). Tek individ\u00ebt e rinj, grumbuj t\u00eb till\u00eb u v\u00ebrejt\u00ebn gjithashtu (<b>1N<\/b>), dmth. bulb\u00ebt e tentakulave mund t\u00eb jen\u00eb zona kryesore e proliferimit gjat\u00eb t\u00eb gjith\u00eb faz\u00ebs meduzane. E habitshme, numri i qelizave pozitive EdU n\u00eb manubrium e individ\u00ebve t\u00eb rritur ishte duksh\u00ebm m\u00eb i lart\u00eb se te ata t\u00eb rinj (<b>2G<\/b> dhe <b>2H<\/b>).<\/p>\n<p>K\u00ebto p\u00ebrfundime tregojn\u00eb se proliferimi i qelizave mund t\u00eb ndodhi n\u00eb m\u00ebnyr\u00eb t\u00eb barabart\u00eb n\u00eb ombrell\u00ebn e meduz\u00ebs, nd\u00ebrsa n\u00eb tentakula ky proces \u00ebsht\u00eb shum\u00eb i lokalizuar. K\u00ebshtu, mund t\u00eb supozohet se proliferimi i barabart\u00eb i qelizave mund t\u00eb kontrolloj\u00eb rritjen e trupit dhe homeostaz\u00ebn e indeve, kurse grumbujt e qelizave n\u00eb proliferim af\u00ebr bulb\u00ebve t\u00eb tentakulave luajn\u00eb nj\u00eb rol n\u00eb morfogjenez\u00ebn e tentakulave.<\/p>\n<p>N\u00eb aspektin e zhvillimit t\u00eb trupit si t\u00eb till\u00eb, proliferimi luan nj\u00eb rol t\u00eb r\u00ebnd\u00ebsish\u00ebm n\u00eb rritjen e trupit.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/16e9263fefd476548addcde85f6f16e2.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Imazhi #3: r\u00ebnd\u00ebsia e proliferimit n\u00eb procesin e rritjes s\u00eb trupit t\u00eb meduz\u00ebs.<\/i><\/p>\n<p>P\u00ebr ta testuar k\u00ebt\u00eb n\u00eb praktik\u00eb, shkenc\u00ebtar\u00ebt ndoq\u00ebn rritjen e trupit t\u00eb meduzave, duke filluar nga individ\u00ebt e rinj. P\u00ebrcaktimi i p\u00ebrmasave t\u00eb trupit t\u00eb meduz\u00ebs \u00ebsht\u00eb m\u00eb e leht\u00eb p\u00ebrmes kupol\u00ebs s\u00eb saj, pasi ajo rritet n\u00eb m\u00ebnyr\u00eb uniforme dhe proporcionalisht me gjith\u00eb trupin. <\/p>\n<p>N\u00eb kushte normale ushqimi n\u00eb laborator, p\u00ebrmasa e kupol\u00ebs rritet ndjesh\u00ebm me 54.8% brenda 24 or\u00ebve t\u00eb para \u2014 nga 0.62 \u00b1 0.02 mm\u00b2 n\u00eb 0.96 \u00b1 0.02 mm\u00b2. N\u00eb dit\u00ebt e tjera t\u00eb v\u00ebzhgimit, p\u00ebrmasat u rrit\u00ebn ngadal\u00eb dhe n\u00eb m\u00ebnyr\u00eb t\u00eb qet\u00eb deri n\u00eb 0.98 \u00b1 0.03 mm\u00b2 (<b>3A<\/b>\u2014<b>3C<\/b>).<\/p>\n<p>Medusat nga grupi tjet\u00ebr, q\u00eb ishin privuar nga ushqimi, nuk u rrit\u00ebn, por u zvog\u00ebluan (vija e kuqe n\u00eb grafik <b>3C<\/b>). Analiza qelizore e meduzave q\u00eb ishin n\u00eb nj\u00eb gjendje urie tregoi nj\u00eb num\u00ebr jasht\u00ebzakonisht t\u00eb vog\u00ebl t\u00eb qelizave EdU: 1240.6 \u00b1 214.3 te medusat e grupit kontrollues dhe 433.6 \u00b1 133 te ata n\u00eb uri (<b>3D<\/b>\u2014<b>3H<\/b>). Ky ky \u00ebsht\u00eb nj\u00eb d\u00ebshmitar i drejtp\u00ebrdrejt\u00eb q\u00eb ushqimi ka nj\u00eb ndikim t\u00eb drejtp\u00ebrdrejt\u00eb n\u00eb procesin e proliferimit.<\/p>\n<p>P\u00ebr t\u00eb verifikuar k\u00ebt\u00eb hipotez\u00eb, shkenc\u00ebtar\u00ebt kryen nj\u00eb analiz\u00eb farmakologjike, gjat\u00eb s\u00eb cil\u00ebs bllokuan progresin e ciklit qelizor duke p\u00ebrdorur hidroksikarbamid (CH4N2O2) \u2013 nj\u00eb inhibitor t\u00eb ciklit qelizor q\u00eb shkakton ndales\u00ebn G1. Si rezultat i k\u00ebtij nd\u00ebrhyrjeje, qelizat n\u00eb faz\u00ebn S, t\u00eb identifikuara m\u00eb par\u00eb me an\u00eb t\u00eb EdU, zhdukeshin (<b>3I<\/b>\u2014<b>3L<\/b>). K\u00ebshtu, meduzat q\u00eb ishin ekspozuar ndaj CH4N2O2 nuk treguan rritje trupore, ndryshe nga grupi kontroll (<b>3M<\/b>).<\/p>\n<p>Hapi pasues i hulumtimit ishte studimi i detajuar i tentakleve t\u00eb deg\u00ebzuara t\u00eb meduzave, p\u00ebr t\u00eb konfirmuar supozimin se proliferimi lokal i qelizave n\u00eb tentakle kontribuon n\u00eb morfogjenez\u00ebn e tyre.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/78f364bbb19c83bb5a6b9b9b0c56c832.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Imazhi Nr. 4: ndikimi i proliferimit lokal n\u00eb rritjen dhe deg\u00ebzimin e tentakleve t\u00eb meduzave.<\/i><\/p>\n<p>Tentaklet e nj\u00eb meduze t\u00eb re kan\u00eb nj\u00eb deg\u00eb, por me kalimin e koh\u00ebs numri i tyre rritet. N\u00eb kushte laboratorike, deg\u00ebzimi u rrit me 3 her\u00eb n\u00eb dit\u00ebn e n\u00ebnt\u00eb t\u00eb vrojtimeve (<b>4A<\/b> dhe <b>4\u0421<\/b>).<\/p>\n<p>P\u00ebrs\u00ebri, me p\u00ebrdorimin e CH4N2O2 deg\u00ebzimi i tentakleve nuk u v\u00ebrejt, p\u00ebrve\u00e7se kishte nj\u00eb deg\u00eb (<b>4B<\/b> dhe <b>4C<\/b>). E \u00e7uditshme \u00ebsht\u00eb se heqja e CH4N2O2 nga trupi i meduzave riktheu procesin e deg\u00ebzimit t\u00eb tentakleve, \u00e7ka tregon p\u00ebr reversibilitetin e nd\u00ebrhyrjes mjek\u00ebsore. K\u00ebto v\u00ebzhgime qart\u00eb tregojn\u00eb r\u00ebnd\u00ebsin\u00eb e proliferimit p\u00ebr zhvillimin e tentakleve. <\/p>\n<p>Strekuese nuk do t\u00eb ishin strekuese pa nematocitet (knidosit, pra, qelizat strekuese). Tek meduza e llojit Clytia hemisphaerica, qelizat trunore n\u00eb bulb\u00ebt e tentakleve ofrojn\u00eb nematociste n\u00eb majat e tentakleve pik\u00ebrisht p\u00ebrmes proliferimit t\u00eb qelizave. Natyrisht, shkenc\u00ebtar\u00ebt vendos\u00ebn t\u00eb shqyrtojn\u00eb edhe k\u00ebt\u00eb pohim.<\/p>\n<p>P\u00ebr t\u00eb zbuluar ndonj\u00eb lidhje midis nematociteve dhe proliferimit, u p\u00ebrdor nj\u00eb ngjyrues b\u00ebrthamor, i cili mund t\u00eb sh\u00ebnoj\u00eb poli-\u03b3-glutamatin, i sintetizuar n\u00eb murin e nematocitit (DAPI, pra, 4\u2019,6-diamidino-2-fenilindol).<\/p>\n<p>Ngjyrosja e poli-\u03b3-glutamatit lejoj t\u00eb vler\u00ebsohet madh\u00ebsia e nematociteve, q\u00eb varianti nga 2 n\u00eb 110 \u00b5m\u00b2 (<b>4D<\/b>\u2014<b>4G<\/b>). Gjithashtu u zbulua nj\u00eb sasi e caktuar e nematociteve bosh, do thot\u00eb se k\u00ebto nematocite ishin shteruar (<b>4D<\/b>\u2014<b>4G<\/b>).<\/p>\n<p>Aktiviteti i proliferimit n\u00eb tentakulat e meduzave u verifikua p\u00ebrmes studimit t\u00eb boshll\u00ebqeve n\u00eb nematocitet pas bllokimit t\u00eb ciklit celular p\u00ebrmes CH4N2O2. Pjesa e nematociteve bosh te meduzat pas nd\u00ebrhyrjes mjek\u00ebsore ishte m\u00eb e lart\u00eb se ajo e grupit kontroll: 11.4% \u00b1 2.0% te meduzat nga grupi kontroll dhe 19.7% \u00b1 2.0% te meduzat me CH4N2O2 (<b>4D<\/b>\u2014<b>4G<\/b> dhe <b>4H<\/b>). P\u00ebr k\u00ebt\u00eb arsye, edhe pas shterimit, nematocitet vazhdojn\u00eb t\u00eb furnizohen aktivisht me qeliza-paraprak\u00eb p\u00ebr proliferim, e cila konfirmon ndikimin e k\u00ebtij procesi jo vet\u00ebm n\u00eb zhvillimin e tentakulave, por edhe n\u00eb nematogjenez\u00ebn n\u00eb to.<\/p>\n<p>Etapa m\u00eb interesante e k\u00ebrkimit was ishte studimi i aft\u00ebsive rigjeneruese t\u00eb meduzave. Duke marr\u00eb parasysh p\u00ebrqendrimin e lart\u00eb t\u00eb qelizave proliferuese n\u00eb bulbin e tentakullit te meduzat e pjekura <i>Cladonema<\/i>, shkenc\u00ebtar\u00ebt vendos\u00ebn t\u00eb studiojn\u00eb rigjenerimin sakt\u00ebsisht t\u00eb tentakulave.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/8659bf8a7b1e94731654e17f52656ca7.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Imazhi nr. 5: ndikimi i proliferimit n\u00eb rigjenerimin e tentakulave.<\/i><\/p>\n<p>Pas kryerjes s\u00eb diseksionit t\u00eb tentakulave n\u00eb baz\u00eb, u v\u00ebrejt procesi i rigjenerimit (<b>5A<\/b>\u2013<b>5D<\/b>). Gjat\u00eb 24 or\u00ebve t\u00eb para, sh\u00ebrimi ndodhi n\u00eb zon\u00ebn e prerjes (<b>5B<\/b>). N\u00eb dit\u00ebn e dyt\u00eb t\u00eb v\u00ebzhgimeve, maja filloi t\u00eb zgjatej dhe shfaqeshin deg\u00ebzime (<b>5C<\/b>). N\u00eb dit\u00ebn e pest\u00eb, tentakuli ishte plot\u00ebsisht i deg\u00ebzuar (<b>5D<\/b>), p\u00ebr rrjedhoj\u00eb, rigjenerimi i tentakulit mund t\u00eb ndjek\u00eb morfogjenezin normale t\u00eb tentakulit pas zgjedhjes.<\/p>\n<p>P\u00ebr t\u00eb studiuar m\u00eb mir\u00eb faz\u00ebn fillestare t\u00eb rigjenerimit, shkenc\u00ebtar\u00ebt analizuan shp\u00ebrndarjen e qelizave proliferuese me p\u00ebrdorimin e ngjyrosjes PH3 p\u00ebr vizualizimin e qelizave mitotike. <\/p>\n<p>Nd\u00ebrsa qelizat q\u00eb po ndaheshin u v\u00ebrejt\u00ebn shpesh pran\u00eb zon\u00ebs s\u00eb amputuar, qelizat mitotike ishin t\u00eb shp\u00ebrndara n\u00eb bulbin e tentakulave q\u00eb nuk ishin prer\u00eb (<b>5E<\/b> dhe <b>5F<\/b>).<\/p>\n<p>Vler\u00ebsimi sasiore i qelizave PH3-pozitive q\u00eb ishin t\u00eb pranishme n\u00eb bulbin e tentakulave lejoj t\u00eb zbulohen rritje t\u00eb dukshme t\u00eb qelizave PH3-pozitive n\u00eb bulbin e tentakulave te individ\u00ebt me ekstremitete t\u00eb amputuara krahasuar me grupin kontroll (<b>5G<\/b>). Si p\u00ebrfundim, proceset fillestare rigjenerative shoq\u00ebrohen me nj\u00eb rritje aktive t\u00eb proliferimit t\u00eb qelizave n\u00eb bulbin e tentakulave.<\/p>\n<p>Kontrollimi i ndikimit t\u00eb proliferimit n\u00eb regenerim u mund\u00ebsua nga bllokimi i qelizave me p\u00ebrb\u00ebrjen CH4N2O2 pasi u pren\u00eb tentakujt. N\u00eb grupin kontroll, zgjatja e tentakujve pas amputimit ndodhi normalisht, si\u00e7 pritej. Nd\u00ebrsa n\u00eb grupin ku u aplikua CH4N2O2, zgjatja nuk ndodhi, ndofta p\u00ebr shkak se plaga sh\u00ebrohej normalisht (<b>5H<\/b>). N\u00eb fjal\u00eb t\u00eb tjera, sh\u00ebrimi do t\u00eb ndodhte n\u00eb \u00e7do rast, por p\u00ebr nj\u00eb regenerim t\u00eb duhur t\u00eb tentakujve, nevojitet proliferimi.<\/p>\n<p>P\u00ebrfundimisht, shkenc\u00ebtar\u00ebt vendos\u00ebn t\u00eb studiojn\u00eb proliferimin n\u00eb specie t\u00eb tjera meduzash, konkretisht n\u00eb <i>Cytaeis<\/i> dhe <i>Rathkea<\/i>.<\/p>\n<p><img decoding=\"async\" alt=\"Para dasht do t\u00eb sh\u00ebrohet: proliferimi i qelizave dhe aft\u00ebsit\u00eb rigjeneruese t\u00eb meduzave\" src=\"\/wp-content\/uploads\/2019\/10\/f9a4dd1bf1cf687a9a65dc43612b909c.jpg\" style=\"display:block;margin: 0 auto;\" \/><br \/>\n<i>Imazhi Nr. 6: krahasimi i proliferimit n\u00eb meduzat e specieve Cytaeis (majtas) dhe Rathkea (djathtas).<\/i><\/p>\n<p>Me <i>Cytaeis<\/i> Qelizat e pozitive p\u00ebr EdU u vun\u00eb re n\u00eb manubrium, n\u00eb bulbo t\u00eb tentakujve dhe n\u00eb pjes\u00ebn e sip\u00ebrme t\u00eb ombrell\u00ebs (<b>6A<\/b> dhe <b>6V<\/b>). Pozita e qelizave pozitive p\u00ebr PH3 n\u00eb <i>Cytaeis<\/i> \u00ebsht\u00eb shum\u00eb e ngjashme me <i>Cladonema<\/i>, megjithat\u00eb ekzistojn\u00eb disa dallime (<b>6C<\/b> dhe <b>6D<\/b>). Nd\u00ebrsa n\u00eb <i>Rathkea<\/i> qelizat pozitive p\u00ebr EdU dhe PH3 u gjet\u00ebn pothuajse ekskluzivisht n\u00eb zon\u00ebn e manubriumit dhe bulbo t\u00eb tentakujve (<b>6E<\/b>\u2014<b>6H<\/b>).<\/p>\n<p>Gjithashtu \u00ebsht\u00eb interesante se qelizat proliferuese shpesh u vun\u00eb re n\u00eb gj\u00ebndrat e meduz\u00ebs <i>Rathkea<\/i> (<b>6E<\/b>\u2014<b>6G<\/b>), q\u00eb tregon p\u00ebr m\u00ebnyr\u00ebn e shumimit pa ndihm\u00ebn e gjinive t\u00eb k\u00ebtij lloji.<\/p>\n<p>Duke marr\u00eb parasysh informacionin e marr\u00eb, mund t\u00eb supozohet se proliferimi i qelizave ndodh n\u00eb bulbos e tentakujve jo vet\u00ebm n\u00eb nj\u00eb lloj meduze, megjithat\u00eb ekzistojn\u00eb dallime q\u00eb vijn\u00eb nga ndryshimi n\u00eb fiziologji dhe morfologji.<\/p>\n<p>P\u00ebr nj\u00eb njohje m\u00eb t\u00eb detajuar t\u00eb nuancave t\u00eb hulumtimit, rekomandoj t\u00eb shikoni n\u00eb <noindex><a rel=\"nofollow\" href=\"https:\/\/peerj.com\/articles\/7579.pdf\">raportin e shkenc\u00ebtar\u00ebve<\/a><\/noindex>.<\/p>\n<h3>Epilogu<\/h3>\n<p>\nNj\u00eb nga personazhet e mi t\u00eb preferuar letrar\u00eb \u00ebsht\u00eb Hercule Poirot. Detektivi perceptues gjithmon\u00eb i kushtonte v\u00ebmendje t\u00eb ve\u00e7ant\u00eb detajeve t\u00eb vogla, t\u00eb cilat t\u00eb tjer\u00ebt i perceptonin si t\u00eb par\u00ebnd\u00ebsishme. Shkenc\u00ebtar\u00ebt shum\u00eb i ngjajn\u00eb detektiv\u00ebve, t\u00eb cil\u00ebt mbledhin \u00e7do prov\u00eb q\u00eb mund t\u00eb gjejn\u00eb, p\u00ebr t\u00eb p\u00ebrgjigjur t\u00eb gjitha pyetjet e hetimit dhe p\u00ebr t\u00eb zbuluar \"fajtorin\". <\/p>\n<p>Si\u00e7 duket e qart\u00eb, regenerimi i qelizave t\u00eb meduzave \u00ebsht\u00eb drejtp\u00ebrdrejt i lidhur me proliferimin \u2014 nj\u00eb proces thelb\u00ebsor n\u00eb zhvillimin e qelizave, indeve dhe, si pasoj\u00eb, t\u00eb gjith\u00eb organizmit. Nj\u00eb studim m\u00eb i thell\u00eb i k\u00ebtij procesi gjith\u00ebp\u00ebrfshir\u00ebs do t\u00eb lejoj\u00eb nj\u00eb kuptim m\u00eb t\u00eb mir\u00eb t\u00eb mekanizmave molekular\u00eb q\u00eb q\u00ebndrojn\u00eb n\u00eb themel, gj\u00eb q\u00eb do t\u00eb ndikoj\u00eb n\u00eb m\u00ebnyr\u00eb t\u00eb drejtp\u00ebrdrejt\u00eb n\u00eb jet\u00ebn ton\u00eb. <\/p>\n<p><b class=\"spoiler_title\">Tema e p\u00ebrgjithshme e Premtes:<\/b><center><div class=\"youtube-placeholder\" data-id=\"-dMcUH2rMnY\" onclick=\"loadVideo(this)\">\r\n        <img decoding=\"async\" src=\"https:\/\/img.youtube.com\/vi\/-dMcUH2rMnY\/hqdefault.jpg\" alt=\"Luaj videon\" loading=\"lazy\" width=\"480\" height=\"360\" style=\"width:100%;height:auto;\">\r\n        <div class=\"play-button\"><\/div>\r\n    <\/div><\/center><br \/>\n<i>Marshi i meduzave t\u00eb llojit aurelia, i shqet\u00ebsuar nga nj\u00eb grabitqar me emrin e pazakont\u00eb \u00abfried egg jellyfish\u00bb, pra meduza vez\u00eb e f\u00ebrguar (Planet Earth, z\u00ebri pas sken\u00ebs \u2014 David Attenborough).<\/i><\/p>\n<p><center><div class=\"youtube-placeholder\" data-id=\"u7QXdlSBGGY\" onclick=\"loadVideo(this)\">\r\n        <img decoding=\"async\" src=\"https:\/\/img.youtube.com\/vi\/u7QXdlSBGGY\/hqdefault.jpg\" alt=\"Luaj videon\" loading=\"lazy\" width=\"480\" height=\"360\" style=\"width:100%;height:auto;\">\r\n        <div class=\"play-button\"><\/div>\r\n    <\/div><\/center><br \/>\n<i>Nuk \u00ebsht\u00eb meduz\u00eb, por kjo krijes\u00eb e thell\u00ebsive t\u00eb detit (pelikani i madh me goj\u00eb t\u00eb gjer\u00eb) nuk kapet shum\u00eb shpesh (reaksioni i studiuesve \u00ebsht\u00eb thjesht magjeps\u00ebs).<\/i><\/p>\n<p>Faleminderit p\u00ebr v\u00ebmendjen, q\u00ebndroni kureshtar dhe u d\u00ebshiroj nj\u00eb fundjav\u00eb t\u00eb shk\u00eblqyer, djem! \ud83d\ude42<\/p>\n<p>\nFaleminderit q\u00eb po q\u00ebndroni me ne. Ju p\u00eblqen artikujt tan\u00eb? Doni t\u00eb shihni m\u00eb shum\u00eb materiale interesante? Na mb\u00ebshtesni duke b\u00ebr\u00eb nj\u00eb porosi ose duke rekomanduar tek miqt\u00eb tuaj, <b>30% zbritje p\u00ebr p\u00ebrdoruesit e Habra n\u00eb nj\u00eb analog unik t\u00eb server\u00ebve entry-level, t\u00eb cilin e kemi shpikur p\u00ebr ju:<\/b> <noindex><a rel=\"nofollow\" href=\"https:\/\/habr.com\/company\/ua-hosting\/blog\/347386\/\">E gjith\u00eb e v\u00ebrteta p\u00ebr VPS (KVM) E5-2650 v4 (6 B\u00ebrthama) 10GB DDR4 240GB SSD 1Gbps nga $20 ose si t\u00eb ndajm\u00eb sakt\u00ebsisht serverin?<\/a><\/noindex> (opcionet me RAID1 dhe RAID10, deri n\u00eb 24 b\u00ebrthama dhe deri n\u00eb 40GB DDR4 jan\u00eb t\u00eb disponueshme).<\/p>\n<p><b>Dell R730xd p\u00ebr dy her\u00eb m\u00eb lir\u00eb?<\/b> Vet\u00ebm te ne <b><noindex><a rel=\"nofollow\" href=\"https:\/\/ua-hosting.company\/serversnl\">2 x Intel TetraDeca-Core Xeon 2x E5-2697v3 2.6GHz 14C 64GB DDR4 4x960GB SSD 1Gbps 100 TB nga $199<\/a><\/noindex> n\u00eb Holand\u00eb! <b>Dell R420 \u2014 2x E5-2430 2.2Ghz 6C 128GB DDR3 2x960GB SSD 1Gbps 100TB \u2014 nga $99!<\/b><\/b> Lexoni rreth <noindex><a rel=\"nofollow\" href=\"https:\/\/habr.com\/company\/ua-hosting\/blog\/329618\/\">Si t\u00eb nd\u00ebrtoni nj\u00eb infrastruktur\u00eb t\u00eb klas\u00ebs korporative me p\u00ebrdorimin e server\u00ebve Dell R730xd E5-2650 v4 me \u00e7mim 9000 euro p\u00ebr pak para?<\/a><\/noindex><br \/>\n<br \/>Burimi: <a content=\"nofollow\" rel=\"nofollow\" href=\"https:\/\/habr.com\/ru\/company\/ua-hosting\/blog\/470934\/\">habr.com<\/a><\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>\u0427\u0442\u043e \u043e\u0431\u0449\u0435\u0433\u043e \u043c\u0435\u0436\u0434\u0443 \u0420\u043e\u0441\u043e\u043c\u0430\u0445\u043e\u0439, \u0414\u044d\u0434\u043f\u0443\u043b\u043e\u043c \u0438 \u043c\u0435\u0434\u0443\u0437\u043e\u0439? \u0412\u0441\u0435 \u043e\u043d\u0438 \u043e\u0431\u043b\u0430\u0434\u0430\u044e\u0442 \u0443\u0434\u0438\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u044c\u044e \u2014 \u0440\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0446\u0438\u0435\u0439. \u041a\u043e\u043d\u0435\u0447\u043d\u043e \u0432 \u043a\u043e\u043c\u0438\u043a\u0441\u0430\u0445 \u0438 \u043a\u0438\u043d\u043e \u044d\u0442\u0430 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c, \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u0430\u044f \u0441\u0440\u0435\u0434\u0438 \u043a\u0440\u0430\u0439\u043d\u0435 \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u043d\u043e\u0433\u043e \u0447\u0438\u0441\u043b\u0430 \u0440\u0435\u0430\u043b\u044c\u043d\u044b\u0445 \u0436\u0438\u0432\u044b\u0445 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u043e\u0432, \u0441\u043b\u0435\u0433\u043a\u0430 (\u0430 \u0438\u043d\u043e\u0433\u0434\u0430 \u0438 \u0441\u0438\u043b\u044c\u043d\u043e) \u043f\u0440\u0435\u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0430, \u043e\u0434\u043d\u0430\u043a\u043e \u043e\u043d\u0430 \u043e\u0441\u0442\u0430\u0435\u0442\u0441\u044f \u0432\u043f\u043e\u043b\u043d\u0435 \u0440\u0435\u0430\u043b\u044c\u043d\u043e\u0439. \u0410 \u0442\u043e, \u0447\u0442\u043e \u0440\u0435\u0430\u043b\u044c\u043d\u043e, \u043c\u043e\u0436\u043d\u043e \u043e\u0431\u044a\u044f\u0441\u043d\u0438\u0442\u044c, \u0447\u0435\u043c \u0438 \u0440\u0435\u0448\u0438\u043b\u0438 \u0437\u0430\u043d\u044f\u0442\u044c\u0441\u044f \u0432 \u0441\u0432\u043e\u0435\u043c \u043d\u043e\u0432\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u0443\u0447\u0435\u043d\u044b\u0435 [&hellip;]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":29148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[702],"tags":[],"class_list":["post-38858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.2.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u0427\u0442\u043e \u043e\u0431\u0449\u0435\u0433\u043e \u043c\u0435\u0436\u0434\u0443.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Yuri Gagarin\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/prohoster.info\/sq\/blog\/news\/do-svadby-zazhivet-proliferatsiya-kletok-i-regenerativnye-sposobnosti-meduz\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.2.1\" \/>\n\t\t<meta 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