{"id":41464,"date":"2020-02-11T12:07:54","date_gmt":"2020-02-11T09:07:54","guid":{"rendered":"https:\/\/prohoster.info\/blog\/blog_prohoster\/immunnyj-imprinting-v-detstve-proishozhdenie-zashhity-ot-virusov"},"modified":"2020-02-11T12:07:54","modified_gmt":"2020-02-11T09:07:54","slug":"immunnyj-imprinting-v-detstve-proishozhdenie-zashhity-ot-virusov","status":"publish","type":"post","link":"https:\/\/prohoster.info\/sq\/blog\/immunnyj-imprinting-v-detstve-proishozhdenie-zashhity-ot-virusov","title":{"rendered":"Imunizimi n\u00eb f\u00ebmij\u00ebri: origjina e mbrojtjes nga viruset","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"Imunizimi
\n
\nGati \u00e7do nga ne ka d\u00ebgjuar ose lexuar lajmet p\u00ebr koronavirusin q\u00eb po p\u00ebrhapet. Si dhe n\u00eb rastin e \u00e7do s\u00ebmundjeje tjet\u00ebr, diagnostikimi i hersh\u00ebm \u00ebsht\u00eb i r\u00ebnd\u00ebsish\u00ebm n\u00eb luft\u00ebn kund\u00ebr virusit t\u00eb ri. Megjithat\u00eb, jo t\u00eb gjith\u00eb ata q\u00eb infektohen tregojn\u00eb t\u00eb nj\u00ebjtin grup simptomash, dhe madje skanerat n\u00eb aeroportet, t\u00eb destinuar p\u00ebr t\u00eb zbuluar shenjat e infeksionit, nuk e p\u00ebrcaktojn\u00eb gjithmon\u00eb me sukses t\u00eb s\u00ebmurin mes turm\u00ebs s\u00eb udh\u00ebtar\u00ebve. Kjo ngre pyetjen \u2014 pse i nj\u00ebjti virus shfaqet ndryshe te njer\u00ebz t\u00eb ndrysh\u00ebm? Natyrisht, p\u00ebrgjigjja e par\u00eb \u00ebsht\u00eb imuniteti. Megjithat\u00eb, ky nuk \u00ebsht\u00eb parametrin i vet\u00ebm i r\u00ebnd\u00ebsish\u00ebm q\u00eb ndikon n\u00eb variabilitetin e simptomave dhe ashp\u00ebrsin\u00eb e s\u00ebmundjes. Shkenc\u00ebtar\u00ebt nga Universiteti i Kalifornis\u00eb dhe Universiteti i Arizon\u00ebs (SHBA) zbuluan se fuqia e rezistenc\u00ebs ndaj viruseve nuk varet vet\u00ebm nga n\u00ebnllojt\u00eb e gripit q\u00eb njeriu ka kaluar gjat\u00eb jet\u00ebs, por edhe nga renditja e tyre. \u00c7far\u00eb kan\u00eb zbuluar shkenc\u00ebtar\u00ebt, cilat metodologji jan\u00eb p\u00ebrdorur n\u00eb hulumtim dhe si mund t\u00eb ndihmoj\u00eb ky punim n\u00eb luft\u00ebn kund\u00ebr epidemive? P\u00ebgjigjet e k\u00ebtyre pyetjeve do t'i gjejm\u00eb n\u00eb raportin e grupit k\u00ebrkues. Le t\u00eb vazhdojm\u00eb.<\/a><\/noindex><\/p>\n

Baza e k\u00ebrkimit<\/h3>\n

\nSi\u00e7 e dim\u00eb, gripi shfaqet ndryshe tek njer\u00ebz t\u00eb ndrysh\u00ebm. P\u00ebrve\u00e7 faktor\u00ebve njer\u00ebzor\u00eb (sistemi imunitar, p\u00ebrdorimi i barnave antivirale, masat parandaluese, etj.), nj\u00eb aspekt i r\u00ebnd\u00ebsish\u00ebm \u00ebsht\u00eb vet\u00eb virusi, dhe m\u00eb sakt\u00ebsisht n\u00ebnlloji me t\u00eb cilin \u00ebsht\u00eb infektuar ai ose ajo. \u00c7do n\u00ebnlloj ka ve\u00e7ori t\u00eb veta, p\u00ebrfshir\u00eb grad\u00ebn e prekjeve t\u00eb grupeve demografike t\u00eb ndryshme. Shkenc\u00ebtar\u00ebt v\u00ebrejn\u00eb se viruset H1N1 (\u201cgripi i derrit\u201d) dhe H3N2 (gripi i Hong Kongut), t\u00eb cilat jan\u00eb b\u00ebr\u00eb m\u00eb t\u00eb zakonshmet deri m\u00eb tani, prekin ndryshe njer\u00ebzit e moshave t\u00eb ndryshme: H3N2 \u00ebsht\u00eb shkaku kryesor i shumic\u00ebs s\u00eb rasteve t\u00eb r\u00ebnda t\u00eb s\u00ebmundjes te t\u00eb moshuarit, dhe i atribuohet shumic\u00ebs s\u00eb rasteve fatale; H1N1 \u00ebsht\u00eb m\u00eb pak vdekjeprur\u00ebs, por prek m\u00eb shpesh njer\u00ebzit e mosh\u00ebs s\u00eb mesme dhe t\u00eb rinjt\u00eb. <\/p>\n

K\u00ebto dallime mund t\u00eb jen\u00eb t\u00eb shkaktuara nga ndryshimi n\u00eb shpejt\u00ebsin\u00eb e evolucionit t\u00eb vet\u00eb viruseve, ashtu si edhe nga dallime n\u00eb imunologjin\u00eb e imprinting*<\/i> tek f\u00ebmij\u00ebt.<\/p>\n

Imunologjia e imprinting*<\/b> \u00ebsht\u00eb nj\u00eb lloj kujtese afatgjat\u00eb e sistemit imunitar, e formuar mbi baz\u00ebn e sulmeve virale q\u00eb ka p\u00ebrjetuar organizmi dhe reagimeve t\u00eb tij ndaj tyre.<\/p><\/blockquote>\n

N\u00eb k\u00ebt\u00eb studim, shkenc\u00ebtar\u00ebt kryen nj\u00eb analiz\u00eb t\u00eb t\u00eb dh\u00ebnave epidemiologjike p\u00ebr t\u00eb kuptuar n\u00ebse imprintimi n\u00eb f\u00ebmij\u00ebri ndikon n\u00eb epidemiologjin\u00eb e gripit sezonal dhe n\u00ebse po, a vepron kryesisht n\u00ebp\u00ebrmjet homosubtipik*<\/i> memoris\u00eb imune ose n\u00ebp\u00ebrmjet nj\u00eb heterosubtipik*<\/i> memorie.<\/p>\n

Imuniteti homosubtipik*<\/b> \u2014 infektimi nga viruset sezonale t\u00eb gripit A ndihmon n\u00eb zhvillimin e mbrojtjes imunitare kund\u00ebr n\u00ebnloj\u00ebs specifike t\u00eb virusit.<\/p><\/blockquote>\n

Imuniteti heterosubtipik* <\/b> \u2014 infektimi nga viruset sezonale t\u00eb gripit A ndihmon n\u00eb zhvillimin e mbrojtjes imunitare kund\u00ebr sub-llojve t\u00eb virusit q\u00eb nuk jan\u00eb t\u00eb ngjash\u00ebm me k\u00ebt\u00eb virus.<\/p><\/blockquote>\n

Me fjal\u00eb t\u00eb tjera, imuniteti i f\u00ebmij\u00ebve dhe gjith\u00e7ka q\u00eb ai ka p\u00ebrjetuar l\u00eb nj\u00eb gjurm\u00eb n\u00eb imunitet p\u00ebr t\u00ebr\u00eb jet\u00eb. Studime t\u00eb m\u00ebparshme kan\u00eb treguar se t\u00eb rriturit kan\u00eb nj\u00eb imunitet m\u00eb t\u00eb fort\u00eb ndaj atyre llojeve t\u00eb viruseve me t\u00eb cilat jan\u00eb infektuar n\u00eb f\u00ebmij\u00ebri. Po ashtu, s\u00eb fundmi \u00ebsht\u00eb v\u00ebrtetuar se imprintimi mbron nga n\u00ebnllojt e reja t\u00eb virusit t\u00eb gripit t\u00eb pulave t\u00eb po t\u00eb nj\u00ebjt\u00ebs grup filogjenetik t\u00eb hemagglutinin\u00ebs (hemagglutinin\u00eb<\/i>, HA), ashtu si\u00e7 ndodh me infektimin e par\u00eb n\u00eb f\u00ebmij\u00ebri. <\/p>\n

Derisa deri tani imuniteti i ngusht\u00eb mbrojt\u00ebs kryq\u00ebzues specifik p\u00ebr variantet e nj\u00eb n\u00ebnloje HA ishte konsideruar si m\u00ebnyra kryesore e mbrojtjes ndaj gripit sezonal. Megjithat\u00eb, ka t\u00eb dh\u00ebna t\u00eb reja q\u00eb propozojn\u00eb se formimi i imunitetit mund t\u00eb ndikoj\u00eb edhe nga memoria e antigjen\u00ebve t\u00eb tjer\u00eb t\u00eb gripit (p.sh., neuraaminidaze, NA). Q\u00eb nga viti 1918, midis njer\u00ebzve jan\u00eb regjistruar tre n\u00ebnlloj t\u00eb HA: H1, H2 dhe H3. Nd\u00ebrsa H1 dhe H2 i p\u00ebrkasin grupit filogjenetik 1, H3 i p\u00ebrket grupit 2.<\/p>\n

N\u00ebse e marrim parasysh faktin se imprintimi, p\u00ebr t\u00eb cilin \u00ebsht\u00eb m\u00ebse e sigurt se shkakton shum\u00eb ndryshime n\u00eb memorien imune, mund t\u00eb supozojm\u00eb se k\u00ebto ndryshime kan\u00eb nj\u00eb hierarki t\u00eb caktuar. <\/p>\n

Shkenc\u00ebtar\u00ebt theksojn\u00eb se q\u00eb nga viti 1977, n\u00eb popullat\u00eb kan\u00eb qarkulluar dy podtypet e gripit A - H1N1 dhe H3N2. Diferencat n\u00eb demografin\u00eb e infeksionit dhe simptomat kan\u00eb qen\u00eb mjaft t\u00eb evidentuara, por keq t\u00eb studiuara. K\u00ebto dallime mund t\u00eb lidhen me imprintimin n\u00eb f\u00ebmij\u00ebri: njer\u00ebzit e moshuar pothuajse me siguri jan\u00eb ekspozuar ndaj H1N1 n\u00eb f\u00ebmij\u00ebri (nga 1918 deri n\u00eb 1975, ky ka qen\u00eb vet\u00ebm podtypi i qarkulluar midis njer\u00ebzve). Si rezultat, k\u00ebta njer\u00ebz jan\u00eb m\u00eb t\u00eb mbrojtur nga variantet sezonale moderne t\u00eb virusit t\u00eb k\u00ebtij podtypi. Po ashtu, tek t\u00eb rinjt\u00eb, probabiliteti m\u00eb i lart\u00eb i imprintimit n\u00eb f\u00ebmij\u00ebri lidhet me H3N2 m\u00eb moderne (foto \u21161), e cila \u00ebsht\u00eb n\u00eb p\u00ebrputhje me numrin relativisht t\u00eb ul\u00ebt t\u00eb rasteve klinikisht t\u00eb regjistruara H3N2 n\u00eb k\u00ebt\u00eb grup demografik.<\/p>\n

\"Imunizimi
\nFoto \u21161: variantet e modeleve t\u00eb varshm\u00ebris\u00eb s\u00eb imunitetit nga imprintimi n\u00eb f\u00ebmij\u00ebri dhe faktor\u00ebt e evoluimit t\u00eb virusit.<\/i><\/p>\n

Nga ana tjet\u00ebr, k\u00ebto dallime mund t\u00eb lidhen me evolucionin e vet\u00eb podtypave t\u00eb virusit. H3N2 tregon nj\u00eb drift m\u00eb t\u00eb shpejt\u00eb drift*<\/i> t\u00eb fenotipit t\u00eb tij antigjenik, sesa H1N1.<\/p>\n

Drifti i antigjeneve*<\/b> \u00ebsht\u00eb ndryshime n\u00eb faktor\u00ebt sip\u00ebrfaq\u00ebsor\u00eb q\u00eb formojn\u00eb imunitet t\u00eb virusit.<\/p><\/blockquote>\n

P\u00ebr k\u00ebt\u00eb arsye, H3N2 mund t\u00eb shmang\u00eb m\u00eb mir\u00eb imunitetin e formuar m\u00eb par\u00eb te t\u00eb rriturit q\u00eb kan\u00eb p\u00ebrvoj\u00eb imunologjike (dhe q\u00eb kan\u00eb kaluar m\u00eb par\u00eb gripin), nd\u00ebrsa H1N1 mund t\u00eb jet\u00eb relativisht e kufizuar n\u00eb fuqin\u00eb e ndikimit t\u00eb saj kryesisht ndaj f\u00ebmij\u00ebve imunologjikisht t\u00eb pa p\u00ebrvoj\u00eb (q\u00eb nuk kan\u00eb pasur kurr\u00eb grip).<\/p>\n

P\u00ebr t\u00eb verifikuar t\u00eb gjitha hipotezat e mundshme, shkenc\u00ebtar\u00ebt kryen nj\u00eb analiz\u00eb t\u00eb t\u00eb dh\u00ebnave epidemiologjike, duke krijuar funksione probabiliteti p\u00ebr \u00e7do variant t\u00eb modeleve statistikore, krahasimi i t\u00eb cilave u b\u00eb p\u00ebrmes kriterit informativ t\u00eb Akaikes (AIC). <\/p>\n

Po ashtu, u krye nj\u00eb analiz\u00eb shtes\u00eb e hipotez\u00ebs, ku dallimet nuk jan\u00eb t\u00eb bazuara n\u00eb imprintim, por n\u00eb evolucionin e viruset.<\/p>\n

P\u00ebrgatitja p\u00ebr studim<\/h3>\n

\nN\u00eb modelimin e hipotezave u p\u00ebrdor\u00ebn t\u00eb dh\u00ebnat nga Departamenti i Sh\u00ebndet\u00ebsis\u00eb i Arizon\u00ebs (ADHS), konkretisht 9510 raste sezonal H1N1 dhe H3N2 n\u00eb t\u00eb gjith\u00eb shtetin. Rreth 76% e rasteve t\u00eb regjistruara u dokumentuan n\u00eb spitale dhe laboratore, nd\u00ebrsa rastet e tjera nuk u sakt\u00ebsuan n\u00eb laborator\u00eb. Gjithashtu, dihet se rreth gjysma e rasteve t\u00eb identifikuara n\u00eb laborator ishin mjaft serioze, duke \u00e7uar n\u00eb hospitalizim. <\/p>\n

T\u00eb dh\u00ebnat e p\u00ebrdorura n\u00eb studim i p\u00ebrkasin nj\u00eb periudhe prej 22 vitesh: nga sezoni i gripit 1993\u20131994 deri n\u00eb sezonin 2014\u20132015. \u00cbsht\u00eb e r\u00ebnd\u00ebsishme t\u00eb theksohet se madh\u00ebsit\u00eb e mostrave pat\u00ebn nj\u00eb rritje t\u00eb mpreht\u00eb pas pandemis\u00eb s\u00eb vitit 2009, prandaj kjo periudh\u00eb u p\u00ebrjashtua nga muestra (Tabela Nr. 1).<\/p>\n

\"Imunizimi
\nTabela Nr. 1: t\u00eb dh\u00ebnat epidemiologjike nga 1993 deri n\u00eb 2015 lidhur me rastet e regjistruara t\u00eb viruseve H1N1 dhe H3N2.<\/i><\/p>\n

Gjithashtu, \u00ebsht\u00eb e r\u00ebnd\u00ebsishme t\u00eb merret parasysh se nga viti 2004, laborator\u00ebt komercial\u00eb n\u00eb SHBA ishin t\u00eb detyruar t\u00eb raportonin autoriteteve sh\u00ebndet\u00ebsore shtet\u00ebrore t\u00eb gjitha t\u00eb dh\u00ebnat n\u00eb lidhje me infeksionet virale t\u00eb pacient\u00ebve. Megjithat\u00eb, shumica e rasteve t\u00eb analizuara (9150\/9451) u vun\u00eb re q\u00eb nga sezoni 2004\u20132005, tashm\u00eb pas hyrjes n\u00eb fuqi t\u00eb k\u00ebsaj rregulloreje.<\/p>\n

Nga t\u00eb gjitha 9510 rasteve, 58 u p\u00ebrjashtuan, sepse ishin individ\u00eb me vit lindjeje para 1918 (statusi i tyre mbi imprinting nuk mund t\u00eb p\u00ebrcaktohet qart\u00eb), dhe nj\u00eb rast tjet\u00ebr p\u00ebr shkak t\u00eb vitit t\u00eb lindjes s\u00eb pasakt\u00eb. K\u00ebshtu, n\u00eb modelin e analiz\u00ebs u p\u00ebrfshin\u00eb 9541 raste.<\/p>\n

N\u00eb faz\u00ebn e par\u00eb t\u00eb modelimit, u p\u00ebrcaktuan probabilitetet e imprinted n\u00eb viruset H1N1, H2N2 ose H3N2, specifike p\u00ebr vitin e lindjes. K\u00ebto probabilitete pasqyrojn\u00eb natyr\u00ebn e ndikimit t\u00eb gripit A mbi f\u00ebmij\u00ebt dhe p\u00ebrhapjen e tij n\u00eb vite. <\/p>\n

Shumica e individ\u00ebve t\u00eb lindur n\u00eb periudh\u00ebn midis pandemive t\u00eb vitit 1918 dhe 1957 u infektuan p\u00ebr her\u00eb t\u00eb par\u00eb me n\u00ebnlak H1N1. Individ\u00ebt e lindur midis pandemive 1957 dhe 1968, pothuajse t\u00eb gjith\u00eb, u infektuan me n\u00ebnlak H2N2 (1A<\/b>). Dhe nga viti 1968, n\u00ebnlak dominuese e virusit ishte H3N2, q\u00eb shkaktoi infektimin e shumic\u00ebs s\u00eb individ\u00ebve nga grupi demografik i ri.<\/p>\n

Megjith\u00ebse H3N2 \u00ebsht\u00eb p\u00ebrhapur, H1N1 ka qarkulluar sezonalisht mes popullsis\u00eb q\u00eb nga viti 1977, duke shkaktuar imprinted tek disa individ\u00eb t\u00eb lindur nga mesi i viteve 1970 (1A<\/b>).<\/p>\n

N\u00ebse imprintimi n\u00eb nivelin e podtipit HA formon probabilitetin e infektimit gjat\u00eb gripit sezonal, at\u00ebher\u00eb ekspozimi ndaj podtipave HA H1 ose H3 n\u00eb f\u00ebmij\u00ebrin\u00eb e hershme duhet t\u00eb ofroj\u00eb imunitet t\u00eb p\u00ebrjetsh\u00ebm ndaj varianteve m\u00eb aktuale t\u00eb t\u00eb nj\u00ebjtit podtip HA. N\u00ebse imuniteti i imprintimit funksionon kryesisht kund\u00ebr llojeve t\u00eb caktuara t\u00eb NA (neuraminidaza), at\u00ebher\u00eb mbrojtja e p\u00ebrjetshme do t\u00eb karakterizohet p\u00ebr N1 ose N2 (1B<\/b>).<\/p>\n

N\u00ebse imprintimi \u00ebsht\u00eb i bazuar n\u00eb nj\u00eb HA m\u00eb t\u00eb gjer\u00eb, dmth. ka mbrojtje nga nj\u00eb spektri m\u00eb t\u00eb gjer\u00eb t\u00eb podtipave, at\u00ebher\u00eb njer\u00ebzit me imprintim nga H1 dhe H2 duhet t\u00eb jen\u00eb t\u00eb mbrojtur nga gripi sezonal modern H1N1. Nd\u00ebrkoh\u00eb, njer\u00ebzit me imprintim nga H3 do t\u00eb mbrohen vet\u00ebm nga gripi sezonal modern H3N2 (1B<\/b>).<\/p>\n

Shkenc\u00ebtar\u00ebt theksojn\u00eb se kollineariteti (n\u00eb terma t\u00eb thjesht\u00eb, paralelizmi) i parashikimeve t\u00eb modeleve t\u00eb ndryshme t\u00eb imprintimit (1D<\/b>\u20141I<\/b>) ishte i pashmangsh\u00ebm, duke pasur parasysh larmishm\u00ebrin\u00eb e kufizuar t\u00eb podtipave antigjenik\u00eb t\u00eb gripit q\u00eb qarkullojn\u00eb midis popullsis\u00eb gjat\u00eb nj\u00eb shekulli t\u00eb kaluar.<\/p>\n

Roli m\u00eb i r\u00ebnd\u00ebsish\u00ebm n\u00eb diferencimin nd\u00ebrmjet imprintimit n\u00eb nivelin e podtipit HA, podtipit NA ose n\u00eb nivelin e grupit HA e luajn\u00eb njer\u00ebzit e moshuar mesatar\u00eb, t\u00eb cil\u00ebt u infektuan p\u00ebr her\u00eb t\u00eb par\u00eb me H2N2 (1B<\/b>). <\/p>\n

\u00c7do nj\u00eb nga modelet e verifikuara p\u00ebrdori nj\u00eb kombinim linear t\u00eb infektimit t\u00eb lidhur me mosh\u00ebn (1C<\/b>), dhe infektimit t\u00eb lidhur me vitin e lindjes (1D<\/b>\u20141F<\/b>) p\u00ebr t\u00eb marr\u00eb shp\u00ebrndarjen e rasteve H1N1 ose H3N2 (1G<\/b> \u2013 1I<\/b>).<\/p>\n

N\u00eb total jan\u00eb krijuar 4 modele: modeli m\u00eb i thjesht\u00eb p\u00ebrfshinte vet\u00ebm faktor\u00eb mosh\u00eb, nd\u00ebrsa n\u00eb modelet m\u00eb t\u00eb komplikuara jan\u00eb shtuar faktor\u00ebt e imprintimit n\u00eb nivelin e podtipit HA, n\u00eb nivelin e podtipit NA ose n\u00eb nivelin e grupit HA.<\/p>\n

Kruva e faktor\u00ebve t\u00eb mosh\u00ebs ka form\u00ebn e nj\u00eb funksioni shkall\u00eb por q\u00eb i vendos rrezikun relativ t\u00eb infektimit si 1 n\u00eb grupin e mosh\u00ebs 0\u20134. P\u00ebrve\u00e7 grupit fillestar t\u00eb mosh\u00ebs, kishte edhe grupet e tjera: 5\u201310, 11\u201317, 18\u201324, 25\u201331, 32\u201338, 39\u201345, 46\u201352, 53\u201359, 60\u201366, 67\u201373, 74\u201380, 81+.<\/p>\n

N\u00eb modelet q\u00eb p\u00ebrfshinin efektet e imprintimit, supozohej se pjesa e njer\u00ebzve n\u00eb \u00e7do vit lindje me imprintim mbrojt\u00ebs n\u00eb f\u00ebmij\u00ebri \u00ebsht\u00eb proporcionale me zvog\u00eblimin e rrezikut t\u00eb infektimit.<\/p>\n

Poashtu, n\u00eb modelim u mor parasysh edhe faktori i evoluimit viral. P\u00ebr k\u00ebt\u00eb, u p\u00ebrdor\u00ebn t\u00eb dh\u00ebnat q\u00eb p\u00ebrshkruanin progresin antitrupor vjetor, i cili ishte p\u00ebrcaktuar si distanca mesatare antitrupore mes linjave t\u00eb caktuara virale (H1N1 deri n\u00eb 2009, H1N1 pas 2009 dhe H3N2). \"Distanca antitrupore\" mes dy llojeve gripale p\u00ebrdoret si nj\u00eb tregues i ngjashm\u00ebris\u00eb s\u00eb fenotipit antigenik dhe potencialit t\u00eb mbrojtjes imunologjike nd\u00ebrkaluese.<\/p>\n

P\u00ebr t\u00eb vler\u00ebsuar ndikimin e evoluimit antigenik n\u00eb shp\u00ebrndarjen moshore epidemike, u krye nj\u00eb verifikim i ndryshimeve n\u00eb pjes\u00ebn e rasteve tek f\u00ebmij\u00ebt n\u00eb sezonet kur ndodhi nj\u00eb ndryshim i fuqish\u00ebm antigenik.<\/p>\n

N\u00ebse niveli i drifti antigenik \u00ebsht\u00eb nj\u00eb faktor vendimtar p\u00ebr rrezikun moshor t\u00eb infektimit, at\u00ebher\u00eb pjesa e rasteve, t\u00eb v\u00ebrejtura tek f\u00ebmij\u00ebt, duhet t\u00eb jet\u00eb negativisht e lidhur me progresin antitrupor vjetor. N\u00eb fjal\u00eb t\u00eb tjera, variante q\u00eb nuk kan\u00eb p\u00ebsuar ndryshime t\u00eb r\u00ebnd\u00ebsishme antigenike n\u00eb krahasim me sezonin e kaluar, duhet t\u00eb jen\u00eb t\u00eb paafta p\u00ebr t\u00eb evituar imunitetin ekzistues te t\u00eb rriturit me p\u00ebrvoj\u00eb imunologjike. K\u00ebto variante do t\u00eb jen\u00eb m\u00eb aktive n\u00eb mesin e popullsis\u00eb pa p\u00ebrvoj\u00eb imunologjike, dometh\u00ebn\u00eb mes f\u00ebmij\u00ebve.<\/p>\n

Rezultatet e studimit<\/h3>\n

\nAnaliza e t\u00eb dh\u00ebnave sipas viteve tregoi se H3N2 sezonal ka qen\u00eb shkaku kryesor i infeksionit mes popullsis\u00eb s\u00eb moshuar, nd\u00ebrsa H1N1 ka prekur individ\u00eb t\u00eb grupmosh\u00ebs s\u00eb mesme dhe t\u00eb rinjt\u00eb (shikoni figur\u00ebn \u21162).<\/p>\n

\"Imunizimi
\nFigura \u21162: shp\u00ebrndarja e gripit H1N1 dhe H3N2 sipas mosh\u00ebs n\u00eb periudha t\u00eb ndryshme kohore.<\/i><\/p>\n

Ky model ishte i pranish\u00ebm si n\u00eb t\u00eb dh\u00ebnat para pandemis\u00eb s\u00eb vitit 2009, ashtu edhe pas saj. <\/p>\n

T\u00eb dh\u00ebnat treguan se imprinti n\u00eb nivelin e n\u00ebnllojit NA dominohet nga imprinti n\u00eb nivelin e n\u00ebnllojit HA (\u0394AIC = 34.54). N\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb, imprinti n\u00eb nivelin e grupit HA ishte pothuajse plot\u00ebsisht i munguar (\u0394AIC = 249.06), ashtu si dhe mungesa totale e imprintit (\u0394AIC = 385.42).<\/p>\n

\"Imunizimi
\nFigura \u21163: vler\u00ebsimi i pajtueshm\u00ebris\u00eb s\u00eb modeleve me t\u00eb dh\u00ebnat e studimit.<\/i><\/p>\n

Vler\u00ebsimi vizual i pajtueshm\u00ebris\u00eb s\u00eb modeleve (3C<\/b> dhe 3D<\/b>) konfirmoi se modelet me efekte imprintingu n\u00eb nivele t\u00eb ngushta n\u00ebnllojsh si NA ose HA ofrojn\u00eb p\u00ebrputhjen m\u00eb t\u00eb mir\u00eb me t\u00eb dh\u00ebnat e p\u00ebrdorura n\u00eb studim. Fakti q\u00eb modeli, n\u00eb t\u00eb cilin imprintingu mungon, nuk mund t\u00eb konfirmohet nga t\u00eb dh\u00ebnat tregon se imprintingu \u00ebsht\u00eb nj\u00eb aspekt shum\u00eb i r\u00ebnd\u00ebsish\u00ebm n\u00eb formimin e imunitetit tek popullsia e rritur ndaj n\u00ebnllojsh t\u00eb sezonit t\u00eb gripit. Megjithat\u00eb, imprintingu funksionon p\u00ebr nj\u00eb specializim shum\u00eb t\u00eb ngusht\u00eb, dmth vepron ekskluzivisht n\u00eb nj\u00eb n\u00ebnlloj t\u00eb caktuar dhe jo n\u00eb nj\u00eb gam\u00eb t\u00eb plot\u00eb n\u00ebnllojsh gripi.<\/p>\n

\"Imunizimi
\nT\u00eb Dh\u00ebna Nr. 2: vler\u00ebsimi i p\u00ebrputhshm\u00ebris\u00eb s\u00eb modeleve me t\u00eb dh\u00ebnat e studimit.<\/i><\/p>\n

Pas marrjes parasysh t\u00eb shp\u00ebrndarjes demografike sipas mosh\u00ebs, rreziku i parashikuar nga mosha ishte m\u00eb i larti tek f\u00ebmij\u00ebt dhe t\u00eb moshuarit, q\u00eb p\u00ebrputhej me grumbullimin e kujtes\u00ebs imunitare n\u00eb f\u00ebmij\u00ebri dhe dob\u00ebsimin e funksionit imunitar tek t\u00eb moshuarit (n\u00eb 3A<\/b> tregohet nj\u00eb kurb\u00eb e af\u00ebrt nga modeli m\u00eb i mir\u00eb). Vler\u00ebsimet e parametrave t\u00eb imprintingu ishin m\u00eb t\u00eb vogla se nj\u00eb, q\u00eb tregon nj\u00eb ulje t\u00eb caktuar t\u00eb rrezikut relativ (Tabela Nr. 2). N\u00eb kuad\u00ebr t\u00eb modelit m\u00eb t\u00eb mir\u00eb, ulja e parashikuar e rrezikut relativ nga imprintingu n\u00eb f\u00ebmij\u00ebri ishte m\u00eb e fort\u00eb p\u00ebr H1N1 (0.34, 95% CI 0.29\u20130.42) sesa p\u00ebr H3N2 (0.71, 95% CI 0.62\u20130.82).<\/p>\n

P\u00ebr t\u00eb verifikuar ndikimin e evolucionit viral n\u00eb shp\u00ebrndarjen e rrezikut t\u00eb infeksionit sipas mosh\u00ebs, shkenc\u00ebtar\u00ebt k\u00ebrkuan nj\u00eb reduktim t\u00eb pjes\u00ebs s\u00eb rasteve t\u00eb infeksionit tek f\u00ebmij\u00ebt n\u00eb periudha t\u00eb lidhura me ndryshimet antigjene, kur variantet me nj\u00eb drif t\u00eb lart\u00eb antigjenik infektuan n\u00eb m\u00ebnyr\u00eb m\u00eb efikase t\u00eb rriturit q\u00eb kishin p\u00ebrvoj\u00eb imunologjike.<\/p>\n

Analiza e t\u00eb dh\u00ebnave tregoi nj\u00eb lidhje t\u00eb vog\u00ebl negative, por jo t\u00eb konsiderueshme midis rritjes vjetore t\u00eb aktiviteteve antigjene dhe pjes\u00ebs s\u00eb rasteve H3N2 t\u00eb observedud n\u00eb f\u00ebmij\u00ebt (4A<\/b>).<\/p>\n

\"Imunizimi
\nImazhi Nr. 4: ndikimi i evolucionit viral n\u00eb faktorin e rrezikut sipas mosh\u00ebs p\u00ebr infeksionin.<\/p>\n

Megjithat\u00eb, nuk u gjet nj\u00eb lidhje e qart\u00eb midis ndryshimeve antigjene dhe pjes\u00ebs s\u00eb rasteve t\u00eb observedud tek f\u00ebmij\u00ebt mbi 10 vje\u00e7 dhe t\u00eb rriturit. Po t\u00eb kishte nj\u00eb rol kryesor evolucioni viral n\u00eb k\u00ebt\u00eb shp\u00ebrndarje, do t\u00eb ishim d\u00ebshmitar\u00eb t\u00eb provave m\u00eb t\u00eb qarta t\u00eb ndikimit evolucionar mes t\u00eb rriturve dhe jo vet\u00ebm gjat\u00eb krahasimit midis t\u00eb rriturve dhe f\u00ebmij\u00ebve n\u00ebn 10 vje\u00e7.<\/p>\n

P\u00ebrve\u00e7 k\u00ebsaj, n\u00ebse shkalla e ndryshimeve evolucionare t\u00eb viruseve \u00ebsht\u00eb dominuese p\u00ebr dallimet e ve\u00e7anta sipas n\u00ebnllojit n\u00eb shp\u00ebrndarjen e mosh\u00ebs epidemike, at\u00ebher\u00eb kur n\u00ebnllojt\u00eb H1N1 dhe H3N2 tregojn\u00eb shkalla t\u00eb nj\u00ebjta t\u00eb shp\u00ebrndarjes vjetore t\u00eb antigjenit, shp\u00ebrndarja e mosh\u00ebs s\u00eb rasteve t\u00eb infektimit duhet t\u00eb duket m\u00eb e ngjashme.<\/p>\n

P\u00ebr nj\u00eb njohje m\u00eb t\u00eb detajuar t\u00eb nuancave t\u00eb hulumtimit, rekomandoj t\u00eb shikoni n\u00eb raportin e shkenc\u00ebtar\u00ebve<\/a><\/noindex>.<\/p>\n

Epilogu<\/h3>\n

\nN\u00eb k\u00ebt\u00eb punim, shkenc\u00ebtar\u00ebt analizuan t\u00eb dh\u00ebnat epidemiologjike t\u00eb rasteve t\u00eb infektimit H1N1, H3N2 dhe H2N2. Analiza e t\u00eb dh\u00ebnave tregoi nj\u00eb var\u00ebsi t\u00eb qart\u00eb t\u00eb imanit n\u00eb f\u00ebmij\u00ebri dhe shkall\u00ebs s\u00eb rrezikut t\u00eb infektimit n\u00eb mosh\u00eb t\u00eb rritur. N\u00eb fjal\u00eb t\u00eb tjera, n\u00ebse nj\u00eb f\u00ebmij\u00eb n\u00eb vitet '50 u infektua kur H1N1 qarkullonte, nd\u00ebrsa H3N2 ishte i pranish\u00ebm, n\u00eb mosh\u00eb t\u00eb rritur probabiliteti i infektimit me H3N2 do t\u00eb jet\u00eb shum\u00eb m\u00eb i lart\u00eb se sa probabiliteti p\u00ebr t\u00eb kapur H1N1.<\/p>\n

Konkluzioni kryesor i k\u00ebtij studimi \u00ebsht\u00eb se \u00ebsht\u00eb e r\u00ebnd\u00ebsishme jo vet\u00ebm \u00e7far\u00eb ka pasur nj\u00eb person n\u00eb f\u00ebmij\u00ebri, por edhe n\u00eb cil\u00ebn renditje. Memoria imunologjike, e cila formohet gjat\u00eb jet\u00ebs, aktivisht 'shkruan' t\u00eb dh\u00ebnat e infeksioneve virale t\u00eb para, duke ndihmuar n\u00eb nj\u00eb kund\u00ebrv\u00ebnie m\u00eb t\u00eb efektshme ndaj tyre n\u00eb mosh\u00eb t\u00eb rritur. <\/p>\n

Shkenc\u00ebtar\u00ebt shpresojn\u00eb se puna e tyre do t\u00eb mund\u00ebsoj\u00eb parashikimin m\u00eb t\u00eb mir\u00eb t\u00eb cilat grupe moshe jan\u00eb m\u00eb t\u00eb prekura nga nj\u00eb n\u00ebnlloj i caktuar t\u00eb gripit. K\u00ebto njohuri mund t\u00eb ndihmojn\u00eb n\u00eb parandalimin e shp\u00ebrthimeve, sidomos kur nevojitet shp\u00ebrndarja e nj\u00eb numri t\u00eb kufizuar vaksinash n\u00eb mesin e popullsis\u00eb. <\/p>\n

Ky studim nuk ka si objektiv gjetjen e super-mjekimeve p\u00ebr gripin e \u00e7do lloji, edhe pse do t\u00eb ishte e shk\u00eblqyer. Ai ka si objektiv di\u00e7ka q\u00eb \u00ebsht\u00eb shum\u00eb m\u00eb reale dhe e r\u00ebnd\u00ebsishme n\u00eb k\u00ebt\u00eb moment \u2014 parandalimin e shp\u00ebrndarjes s\u00eb infeksionit. N\u00ebse ne nuk mund t\u00eb lirojm\u00eb menj\u00ebher\u00eb nga virusi, at\u00ebher\u00eb duhet t\u00eb kemi t\u00eb gjitha mjetet e mundshme p\u00ebr ta frenuar at\u00eb. Nj\u00eb nga aleat\u00ebt m\u00eb t\u00eb sigurt t\u00eb \u00e7do epidemie \u00ebsht\u00eb neglizhenca ndaj saj si nga ana e shtetit n\u00eb t\u00ebr\u00ebsi ashtu edhe nga \u00e7do individ n\u00eb ve\u00e7anti. Panika, natyrisht, nuk \u00ebsht\u00eb e nevojshme, pasi mund t\u00eb sjell\u00eb vet\u00ebm m\u00eb shum\u00eb d\u00ebm, por masat parandaluese kurr\u00eb nuk jan\u00eb t\u00eb tep\u00ebrta.<\/p>\n

Faleminderit p\u00ebr v\u00ebmendjen, q\u00ebndroni kurioz\u00eb, kujdesuni p\u00ebr veten dhe t\u00eb dashurit tuaj dhe t\u00eb keni nj\u00eb fundjav\u00eb t\u00eb shk\u00eblqyer, shok\u00eb! \ud83d\ude42<\/p>\n

Pak reklam\u00eb \ud83d\ude42<\/h3>\n

\nFaleminderit q\u00eb po q\u00ebndroni me ne. Ju p\u00eblqen artikujt tan\u00eb? Doni t\u00eb shihni m\u00eb shum\u00eb materiale interesante? Na mb\u00ebshtesni duke b\u00ebr\u00eb nj\u00eb porosi ose duke rekomanduar tek miqt\u00eb tuaj, VPS cloud p\u00ebr zhvillues nga $4.99<\/a><\/noindex>, nj\u00eb analog unik i server\u00ebve entry-level q\u00eb e kemi shpikur p\u00ebr Ju:<\/b> E gjith\u00eb e v\u00ebrteta n\u00eb lidhje me VPS (KVM) E5-2697 v3 (6 B\u00ebrthama) 10GB DDR4 480GB SSD 1Gbps nga $19 ose si ta ndajm\u00eb sakt\u00ebsisht serverin?<\/a><\/noindex> (opcionet me RAID1 dhe RAID10, deri n\u00eb 24 b\u00ebrthama dhe deri n\u00eb 40GB DDR4 jan\u00eb t\u00eb disponueshme).<\/p>\n

Dell R730xd dyfish m\u00eb i lir\u00eb n\u00eb qend\u00ebr t\u00eb t\u00eb dh\u00ebnave Equinix Tier IV n\u00eb Amsterdam?<\/b> Vet\u00ebm te ne 2 x Intel TetraDeca-Core Xeon 2x E5-2697v3 2.6GHz 14C 64GB DDR4 4x960GB SSD 1Gbps 100 TB nga $199<\/a><\/noindex> n\u00eb Holand\u00eb! Dell R420 \u2014 2x E5-2430 2.2Ghz 6C 128GB DDR3 2x960GB SSD 1Gbps 100TB \u2014 nga $99!<\/b><\/b> Lexoni rreth Si t\u00eb nd\u00ebrtoni nj\u00eb infrastruktur\u00eb t\u00eb klas\u00ebs korporative me p\u00ebrdorimin e server\u00ebve Dell R730xd E5-2650 v4 me \u00e7mim 9000 euro p\u00ebr pak para?<\/a><\/noindex>
\n
Burimi: habr.com<\/a> <\/p>","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

\u041f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u043a\u0430\u0436\u0434\u044b\u0439 \u0438\u0437 \u043d\u0430\u0441 \u0441\u043b\u044b\u0448\u0430\u043b \u0438\u043b\u0438 \u0447\u0438\u0442\u0430\u043b \u043d\u043e\u0432\u043e\u0441\u0442\u0438 \u043e \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u044f\u044e\u0449\u0435\u043c\u0441\u044f \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u0435. \u041a\u0430\u043a \u0438 \u0432 \u0441\u043b\u0443\u0447\u0430\u0435 \u043b\u044e\u0431\u043e\u0433\u043e \u0434\u0440\u0443\u0433\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0432 \u0431\u043e\u0440\u044c\u0431\u0435 \u0441 \u043d\u043e\u0432\u044b\u043c \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0432\u0430\u0436\u043d\u0430 \u0440\u0430\u043d\u043d\u044f\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430. \u041e\u0434\u043d\u0430\u043a\u043e \u0434\u0430\u043b\u0435\u043a\u043e \u043d\u0435 \u0432\u0441\u0435 \u0437\u0430\u0440\u0430\u0437\u0438\u0432\u0448\u0438\u0435\u0441\u044f \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0443\u044e\u0442 \u043e\u0434\u0438\u043d\u0430\u043a\u043e\u0432\u044b\u0439 \u043d\u0430\u0431\u043e\u0440 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432, \u0438 \u0434\u0430\u0436\u0435 \u0441\u043a\u0430\u043d\u0435\u0440\u044b \u0432 \u0430\u044d\u0440\u043e\u043f\u043e\u0440\u0442\u0430\u0445, \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u043d\u044b\u0435 \u0434\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u043e\u0432 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438, \u043d\u0435 \u0432\u0441\u0435\u0433\u0434\u0430 \u0443\u0441\u043f\u0435\u0448\u043d\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442 \u0431\u043e\u043b\u044c\u043d\u043e\u0433\u043e \u0441\u0440\u0435\u0434\u0438 \u0442\u043e\u043b\u043f\u044b \u043f\u0430\u0441\u0441\u0430\u0436\u0438\u0440\u043e\u0432. \u0412\u043e\u0437\u043d\u0438\u043a\u0430\u0435\u0442 \u0432\u043e\u043f\u0440\u043e\u0441 […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":41465,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-41464","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n","aioseo_head_json":{"title":"\ud83e\udd47Imunizimi kaluar n\u00eb f\u00ebmij\u00ebri: origjina e mbrojtjes nga viruset | ProHoster","description":"Praktikisht \u00e7do nga ne.","canonical_url":"https:\/\/prohoster.info\/sq\/blog\/immunnyj-imprinting-v-detstve-proishozhdenie-zashhity-ot-virusov","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":null,"og:locale":"sq_AL","og:site_name":"ProHoster | \u041a\u0443\u043f\u0438\u0442\u044c \u043d\u0430\u0434\u0435\u0436\u043d\u044b\u0439 \u0445\u043e\u0441\u0442\u0438\u043d\u0433 \u0434\u043b\u044f \u0441\u0430\u0439\u0442\u043e\u0432 \u0441 \u0437\u0430\u0449\u0438\u0442\u043e\u0439 \u043e\u0442 DDoS, VPS VDS \u0441\u0435\u0440\u0432\u0435\u0440\u044b","og:type":"article","og:title":"\ud83e\udd47\u0418\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u0438\u043c\u043f\u0440\u0438\u043d\u0442\u0438\u043d\u0433 \u0432 \u0434\u0435\u0442\u0441\u0442\u0432\u0435: \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u0435 \u0437\u0430\u0449\u0438\u0442\u044b \u043e\u0442 \u0432\u0438\u0440\u0443\u0441\u043e\u0432 | ProHoster","og:description":"\u041f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u043a\u0430\u0436\u0434\u044b\u0439 \u0438\u0437 \u043d\u0430\u0441.","og:url":"https:\/\/prohoster.info\/sq\/blog\/immunnyj-imprinting-v-detstve-proishozhdenie-zashhity-ot-virusov","og:image":"https:\/\/prohoster.info\/wp-content\/uploads\/2021\/11\/logo-350.jpg","og:image:secure_url":"https:\/\/prohoster.info\/wp-content\/uploads\/2021\/11\/logo-350.jpg","og:image:width":350,"og:image:height":350,"article:published_time":"2020-02-11T09:07:54+00:00","article:modified_time":"2020-02-11T09:07:54+00:00","article:publisher":"https:\/\/www.facebook.com\/prohoster","article:author":"https:\/\/www.facebook.com\/prohoster"},"aioseo_meta_data":{"post_id":"41464","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":null,"schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"seo_analyzer_scan_date":null,"breadcrumb_settings":null,"limit_modified_date":false,"reviewed_by":null,"ai":null,"created":"2021-03-01 00:16:27","updated":"2022-09-30 07:41:42","focus_keyword":null,"additional_keywords":null,"truseo_locale":null},"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/posts\/41464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/comments?post=41464"}],"version-history":[{"count":0,"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/posts\/41464\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/media\/41465"}],"wp:attachment":[{"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/media?parent=41464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/categories?post=41464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prohoster.info\/sq\/wp-json\/wp\/v2\/tags?post=41464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}