Bafuputsi ba Microsoft le Univesithi ea Washington ba bontšitse mokhoa oa pele oa ho boloka boitsebiso o ikemetseng, o balehang bakeng sa DNA e entsoeng ka maiketsetso. Ena ke mohato oa bohlokoa oa ho tsamaisa theknoloji e ncha ho tloha ho li-lab tsa lipatlisiso ho ea litsing tsa data tsa khoebo.
Bahlahisi ba pakile mohopolo ona ka teko e bonolo: ba ile ba kenya lentsoe "hello" ka katleho likhechana tsa molek'hule ea maiketsetso ea DNA mme ba e khutlisetsa ho data ea dijithale ba sebelisa sistimi e ikemetseng ea ho qetela, e hlalositsoeng ho , e hatisitsoeng ka March 21 ho Nature Scientific Reports.
Limolek'hule tsa DNA li ka boloka boitsebiso ba digital ka ho teteana ho phahameng haholo, ke hore, sebakeng se bonahalang se le senyenyane ka boholo ho feta se sebelisoang ke litsi tsa morao-rao tsa boitsebiso. Ke e 'ngoe ea litharollo tse ts'episang tsa ho boloka palo e kholo ea data eo lefatše le e hlahisang letsatsi le leng le le leng, ho tloha ho lirekoto tsa khoebo le livideo tsa liphoofolo tse ntle ho ea ho linepe tsa bongaka le litšoantšo tse tsoang sebakeng.
Microsoft e ntse e batla litsela tsa ho koala lekhalo le ka bang teng lipakeng tsa mme re batla ho boloka, le bokgoni ba rona ba ho di baballa. Mekhoa ena e kenyelletsa nts'etsopele ea li-algorithms le thekenoloji ea khomphutha ea limolek'hule bakeng sa . Sena se ne se tla lumella tlhahisoleseling eohle e bolokiloeng setsing se seholo sa data sa sejoale-joale hore se kenelle sebakeng se batlang se lekana le mataese a 'maloa.
"Sepheo sa rona se seholo ke ho qala mokhoa oo, ho basebelisi ba ho qetela, o tla shebahala o batla o tšoana le tsamaiso leha e le efe ea polokelo ea leru: tlhahisoleseding e romelloa setsing sa data ebe e bolokoa moo, ebe e hlaha feela ha mofani a e hloka, ” ho bolela Sr. Microsoft mofuputsi Karin Strauss. "Ho etsa sena, re ne re hloka ho paka hore e ne e utloahala ho latela pono ea othomathike."
Boitsebiso bo bolokoa ka har’a limolek’hule tsa maiketsetso tsa DNA tse entsoeng ka laboratoring, ho e-na le ho DNA ea batho kapa lintho tse ling tse phelang, ’me li ka ngolisoa ka mokhoa o patehileng pele li romeloa tsamaisong. Le hoja mechine e rarahaneng e kang li-synthesize le li-sequencer li se li ntse li etsa likarolo tsa bohlokoa tsa ts'ebetso, mehato e mengata e bohareng ho fihlela joale e hloka mosebetsi oa matsoho ka laboratoring ea lipatlisiso. "Ha e ea lokela ho sebelisoa khoebong," ho boletse Chris Takahashi, mofuputsi e moholo oa Paul Allen School of Computer Science le Engineering ho USF.).
"U ke ke ua ba le batho ba pota-potileng setsi sa data ba nang le li-pipette, ho na le phoso e ngata ea batho, e theko e boima haholo 'me e nka sebaka se ngata haholo," Takahashi a hlalosa.
E le hore mokhoa ona oa ho boloka boitsebiso o be o utloahalang khoebong, litšenyehelo tsa motsoako oa DNA—ho etsa lintho tsa motheo tsa tatellano e utloahalang—le mokhoa oa ho latellana o hlokahalang ho bala boitsebiso bo bolokiloeng li lokela ho fokotsoa. Bafuputsi ba re ena ke tataiso .
Boiketsetso ke karolo e 'ngoe ea bohlokoa ea papali, ho boloka data ka tekanyo ea khoebo le ho theko e tlaase, ho latela bafuputsi ba Microsoft.
Tlas'a maemo a itseng, DNA e ka tšoarella nako e telele ho feta mekhoa ea morao-rao ea polokelo ea litlaleho, e senyehang ka lilemo tse mashome. DNA e ’ngoe e khonne ho phela maemong a sa lokang ka lilemo tse mashome a likete—ka har’a manaka a maholohali le masapong a batho ba pele. Sena se bolela hore data e ka bolokoa ka tsela ena ha feela botho bo ntse bo le teng.
Mokhoa o ikemetseng oa ho boloka DNA o sebelisa software e entsoeng ke Microsoft le Univesithi ea Washington (UW). E fetola tsona le li-zero tsa data tsa dijithale ka tatellano ea li-nucleotide (A, T, C le G), e leng "li-blocks tsa kaho" tsa DNA. Ka mor'a moo, tsamaiso e sebelisa lisebelisoa tsa laboratori tse theko e tlaase, haholo-holo tse tsoang ka ntle ho sethala, ho fana ka maro a hlokahalang le li-reagents ho synthesizer, e bokellang likaroloana tsa DNA tse entsoeng ebe li li kenya ka har'a setsi sa polokelo.
Ha tsamaiso e hloka ho ntša boitsebiso, e eketsa lik’hemik’hale tse ling ho lokisa DNA hantle ’me e sebelisa lipompo tsa microfluidic ho sutumelletsa maro likarolong tsa tsamaiso tse balang tatelano ea limolek’hule tsa DNA ebe e li khutlisetsa boitsebiso boo k’homphieutha e ka bo utloisisang. Bafuputsi ba re sepheo sa morero e ne e se ho paka hore tsamaiso e ka sebetsa ka potlako kapa ka theko e tlaase, empa e le feela ho bontša hore automation e ka khoneha.
E 'ngoe ea melemo e totobetseng ea mokhoa oa ho boloka DNA o iketsetsang ke hore o lokolla bo-rasaense ho rarolla mathata a rarahaneng ntle le ho senya nako ho batla libotlolo tsa li-reagents kapa monotony ea ho kenya marotholi a metsi ka har'a li-tubes tsa teko.
"Ho ba le mokhoa o ikemetseng oa ho etsa mosebetsi o pheta-phetoang ho lumella li-labs hore li tsepamise maikutlo ka ho toba lipatlisisong le ho hlahisa mekhoa e mecha ea ho ntlafatsa ka potlako," ho boletse mofuputsi oa Microsoft Bihlin Nguyen.
Sehlopha se tsoang ho Laboratori ea Litsamaiso tsa Boitsebiso ba Limolek'hule (MISL) e se e bontšitse hore e ka boloka linepe tsa likatse, mesebetsi e metle ea lingoliloeng, le ho boloka lirekoto tsa DNA le ho ntša lifaele tsena ntle le liphoso. Ho fihlela joale, ba khonne ho boloka 1 gigabyte ea data ho DNA, ho otla .
Bafuputsi le bona ba thehile mekhoa ea ho joalo ka ho fumana le ho fumana feela litšoantšo tse nang le apole kapa baesekele e tala e sebelisang limolek'hule ka botsona, ntle le ho fetolela lifaele ho sebopeho sa dijithale.
"Ho bolokehile ho bolela hore re bona ho tsoaloa ha mofuta o mocha oa tsamaiso ea lik'homphieutha, moo limolek'hule li sebelisetsoang ho boloka boitsebiso le lisebelisoa tsa elektronike bakeng sa ho laola le ho sebetsa. Motsoako ona o bula menyetla e khahlisang haholo bakeng sa bokamoso, "ho boletse moprofesa oa Sekolo sa Allen Univesithing ea Washington. .
Ho fapana le litsamaiso tsa likhomphutha tse thehiloeng ho silicon, DNA-based storage and computing system e tlameha ho sebelisa maro ho tsamaisa limolek'hule. Empa metsi a fapane ka tlhaho le lielektrone 'me a hloka tharollo e ncha ka ho feletseng ea theknoloji.
Sehlopha sa Univesithi ea Washington, ka tšebelisano 'moho le Microsoft, se boetse se nts'etsapele mokhoa o hlophisitsoeng o iketsetsang liteko tsa laboratori ka ho sebelisa thepa ea motlakase le metsi ho tsamaisa marotholi holim'a marang-rang a li-electrode. Sete e felletseng ea software le hardware e bitsoang , e ka kopanya, ea arola, ea futhumatsa kapa ea pholisa maro a fapaneng le ho etsa liprothocol tsa laboratori.
Sepheo ke ho iketsetsa liteko tsa laboratori tse etsoang hona joale ka letsoho kapa ka liroboto tse bitsang chelete e ngata tse sebetsanang le metsi le ho fokotsa litšenyehelo.
Mehato e latelang ea sehlopha sa MISL e kenyelletsa ho kopanya mokhoa o bonolo, oa ho qetela o ikemetseng o nang le theknoloji e kang Purple Drop, hammoho le mahlale a mang a nolofalletsang ho batla limolek'hule tsa DNA. Bafuputsi ba entse ka boomo sistimi ea bona ea othomathike hore e tle e fetohe joalo ka ha ho hlaha mahlale a macha a DNA synthesis, tatellano le mano.
"E 'ngoe ea melemo ea tsamaiso ena ke hore haeba re batla ho nkela e' ngoe ea likarolo sebaka ka ntho e ncha, e molemo kapa e potlakileng, re ka kenya karolo e ncha feela," ho boletse Nguyen. "Sena se re fa monyetla oa ho fetoha le maemo bakeng sa bokamoso."
Setšoantšo se holimo: Bafuputsi ba Microsoft le Univesithi ea Washington ba ile ba tlaleha le ho bala lentsoe "Lumela", ho sebelisa sistimi ea pele ea polokelo ea data ea DNA e ikemetseng ka botlalo. Ena ke mohato oa bohlokoa oa ho tsamaisa theknoloji e ncha ho tloha lilaboratori ho ea litsing tsa data tsa khoebo.
Source: www.habr.com