Kule mihla, sinokufikelela kulo lonke ulwazi loluntu kwiikhomputha ezincinci ezisezipokothweni zethu. Yonke le datha kufuneka igcinwe kwindawo ethile, kodwa iiseva ezinkulu zithatha indawo eninzi ebonakalayo kwaye zifuna amandla amaninzi. Abaphandi baseHarvard baphuhlise inkqubo entsha yokufunda nokubhala ulwazi besebenzisa iimolekyuli zezinto eziphilayo ezinokuthi zihlale zizinzile kwaye zisebenza kangangamawaka eminyaka.
Kuyaqondakala ukuba iDNA sisixhobo sokugcina inkcazelo kwindaloβinokugcina inkcazelo eninzi kwimolekyuli encinane yaye izinze ngendlela engathethekiyo, yaye iphila kangangamawakawaka eminyaka ikwimeko efanelekileyo. Kutshanje, izazinzulu ziye zahlola obu buchule ngokurekhoda idatha kwi-DNA kwincam yeepensile, kwiitoti zepeyinti yokutshiza, nangokufihla idatha kwiintsholongwane eziphilayo. Kodwa kukho imiqobo ekusebenziseni i-DNA njengesithwala solwazi;
"Siza kusebenzisa isicwangciso esingaboleki iingcamango ngokuthe ngqo kwi-biology," kusho uBrian Cafferty, omnye wababhali besifundo esitsha. "Endaweni yoko, sasithembele kubuchule obuqhelekileyo kwi-organic kunye ne-analytical chemistry kwaye siphuhlise indlela esebenzisa iimolekyuli ezincinci, eziphantsi kwe-molecular-weight-encode information."
Esikhundleni se-DNA, abaphandi basebenzisa i-oligopeptides, iimolekyuli ezincinci ezenziwe ngamanani ahlukeneyo e-amino acids. Isiseko sendawo entsha yokugcina i-microplate - ipleyiti yentsimbi kunye neeseli ezincinci ezingama-384. Iindibaniso ezahlukeneyo ze-oligopeptides zibekwe kwiseli nganye ukuze kufakwe i-byte yolwazi.
Inkqubo isekelwe kwindlela yokubini: ukuba i-oligopeptide ethile ikhona, ifundwa njengo-1, kwaye ukuba akunjalo, ngoko njengo-0. Oku kuthetha ukuba ikhowudi kwiseli nganye inokumela unobumba omnye okanye ipixel enye yomfanekiso. Isitshixo sokuqaphela ukuba yeyiphi i-oligopeptide ekhoyo kwiseli bubunzima bayo, obunokufunyanwa kusetyenziswa i-mass spectrometer.
Kwiimvavanyo zabo, abaphandi bakwazi ukurekhoda, ukugcina nokufunda i-400 KB yolwazi, kubandakanywa nesicatshulwa sentetho, ifoto kunye nomfanekiso. Ngokutsho kweqela, isantya sokubhala esiphakathi sasiyi-bits ezisibhozo ngesibini kwaye isantya sokufunda sasiyi-20 bits ngomzuzwana, ngokuchaneka kwe-99,9%.
Izazinzulu zithi le nkqubo intsha ineengenelo ezininzi. I-Oligopeptides inozinza kumakhulu okanye amawaka eminyaka, ibenze ibe lolona khetho lufanelekileyo lokugcinwa kwedatha yogcino lwexesha elide. Banokugcina idatha eninzi kwindawo encinci ebonakalayo, enokuba ngaphezulu kune-DNA. Ngaloo ndlela, konke okuqulethwe yiThala Loluntu laseNew York kunokugcinwa kwitispuni ezele yiprotini.
Inkqubo inokusebenza kunye noluhlu olubanzi lweeamolekyu kwaye inokubhala idatha ngokukhawuleza kunabalingani bayo base-DNA, nangona abaphandi bavuma ukuba ukufunda kunokucotha kakhulu. Nokuba yeyiphi na indlela, itekhnoloji ingaphuculwa kwixesha elizayo ngeendlela ezingcono, ezifana nokusebenzisa iiprinta ze-inkjet ukurekhoda idatha kunye nokuphucula i-spectrometers yobuninzi ukuyifunda.
Uphononongo lwapapashwa kwijenali yenzululwazi .
umthombo: 3dnews.ru