Iqela lophando kwi-ETH Zurich eSwitzerland Iprosesa yokuqala ye-biosynthetic ye-dual-core kwiseli yomntu. Ukwenza oku, basebenzise indlela ye-CRISPR-Cas9, esetyenziswa ngokubanzi kubunjineli bezofuzo, xa iiprotheyini zeCas9, zisebenzisa ukulawulwa kwaye, umntu unokuthi, izenzo ezicwangcisiweyo, ukuguqula, ukukhumbula okanye ukujonga iDNA yangaphandle. Kwaye ekubeni izenzo zinokucwangciswa, kutheni ungaguquleli indlela ye-CRISPR ukuze isebenze ngokufanayo kumasango edijithali?
Izazinzulu zaseSwitzerland ezikhokelwa yinkokeli yeprojekthi uNjingalwazi uMartin Fussenegger zakwazi ukufaka ii-CRISPR ezimbini zokulandelelana kweDNA kwiibhaktheriya ezimbini ezahlukeneyo kwiseli yomntu. Ngaphantsi kweempembelelo zeprotheyini ye-Cas9 kwaye kuxhomekeke kwimixokelelwane ye-RNA enikezelwe kwiseli, nganye yolandelelwano yavelisa iprotheni yayo ekhethekileyo. Ngaloo ndlela, into ebizwa ngokuba yintetho elawulwayo yemfuza yenzeke, xa, ngokwesiseko solwazi olubhalwe kwi-DNA, imveliso entsha yenziwa - iprotheni okanye i-RNA. Ngokufaniswa nothungelwano lwedijithali, inkqubo ephuhliswe zizazinzulu zaseSwitzerland zinokumelwa njengesiqingatha-adder esinengqiqo kunye neziphumo ezimbini kunye neziphumo ezimbini. Isibonakaliso semveliso (iprotheyini eyahlukileyo) ixhomekeke kwiimpawu ezimbini zokufaka.
Iinkqubo zebhayoloji kwiiseli eziphilayo azinakuthelekiswa neesekethe zekhompyutha zedijithali ngokwesantya sokusebenza. Kodwa iiseli zinokusebenza ngowona mgangatho uphezulu wokunxulunyaniswa, zisebenza ukuya kuthi ga kwi-100 yeemolekyuli ngexesha. Yiba nomfanekiso ngqondweni wezicubu eziphilayo ezinezigidi “zeprosesa” ezingundoqo. Ikhompyuter enjalo inokubonelela ngokusebenza okumangalisayo nakwimigangatho yanamhlanje. Kodwa nokuba sibeka ecaleni ukudalwa kwee-supercomputers "ezithe tye", iibhloko ezenziwe ngengqiqo ezakhiwe emzimbeni womntu zinokunceda ekuxilongeni nasekunyangeni izifo, kuquka umhlaza.
Iibhloko ezinjalo zinokusebenza ngolwazi lwebhayoloji kumzimba womntu njengegalelo kwaye zivelise zombini imiqondiso yokuxilonga kunye nokulandelelana kwe-pharmacological. Ukuba inkqubo yemetastases iqala, umzekelo, iisekethe ezenziweyo ezinengqondo zinokuqalisa ukuvelisa iienzymes ezicinezela umhlaza. Kukho izicelo ezininzi zale nto, kwaye ukuphunyezwa kwayo kunokutshintsha umntu kunye nehlabathi.
umthombo: 3dnews.ru