Ehlobo lika-2018, isikole sasehlobo saminyaka yonke se-bioinformatics sasibanjelwe eduze kwaseSt.
Isikole esasigxile kakhulu ocwaningweni lomdlavuza, kodwa kwaba nezinkulumo kwezinye izindawo ze-bioinformatics, kusukela ekuziphendukeleni kwemvelo kuye ekuhlaziyweni kwedatha yokulandelana kweseli elilodwa. Ngokuhamba kwesonto, abafana bafunde ukusebenzisana nedatha yokulandelana yesizukulwane esilandelayo, ehlelwe ku-Python ne-R, basebenzisa amathuluzi ajwayelekile we-bioinformatics nezinhlaka, bajwayelana nezindlela ze-biology yezinhlelo, izakhi zofuzo kanye nokumodela izidakamizwa lapho kufundwa izimila, nokunye okuningi.
Ngezansi uzothola ividiyo yezinkulumo eziyi-18 ezanikezwa esikoleni, enencazelo emfushane nama-slides. Lawo amakwe ngenkanyezi ethi β*β ayisisekelo futhi angabukwa ngaphandle kokulungiselela kusengaphambili.
1*. I-Oncogenomics kanye ne-oncology yomuntu siqu | Mikhail Pyatnitsky, Research Institute of Biomedical Chemistry
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UMikhail ukhulume kafushane nge-tumor genomics nokuthi ukuqonda ukuvela kwamaseli omdlavuza kusivumela kanjani ukuthi sixazulule izinkinga ezisebenzayo ku-oncology. Umfundisi unake ngokukhethekile ekuchazeni umehluko phakathi kwama-oncogene nama-tumor suppressors, izindlela zokusesha βufuzo lomdlavuzaβ nokuhlonza ama-molecular subtypes ezimila. Ekuphetheni, uMikhail unake ikusasa le-oncogenomics kanye nezinkinga ezingase ziphakame.
2*. Ukuxilongwa kwezakhi zofuzo ze-hereditary tumor syndromes | Andrey Afanasyev, yRisk
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U-Andrey ukhulume nge-hereditary tumor syndromes futhi waxoxa ngebhayoloji yabo, i-epidemiology kanye nokubonakaliswa kwemitholampilo. Ingxenye yenkulumo inikezelwe odabeni lokuhlolwa kwezakhi zofuzo - ukuthi ubani okufanele abhekane nakho, kwenziwani ngalokhu, yiziphi izinkinga eziphakamayo ekucubunguleni idatha nokuhumusha imiphumela, futhi, ekugcineni, yiziphi izinzuzo eziletha iziguli nezihlobo zazo. .
3*. I-Pan-Cancer Atlas | I-German Demidov, BIST/UPF
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Naphezu kwamashumi eminyaka ocwaningo emkhakheni we-cancer genomics kanye ne-epigenomics, impendulo yombuzo othi "kanjani, kuphi futhi kungani i-tumor syndromes ivela" ayiphelele. Esinye isizathu salokhu isidingo sokutholwa okujwayelekile kanye nokucutshungulwa kwenani elikhulu ledatha ukuze kutholwe imiphumela yobukhulu obuncane okunzima ukuyibona kusethi yedatha elinganiselwe (usayizi ovamile ocwaningweni ngaphakathi kwelabhorethri eyodwa noma ezimbalwa) , kodwa okuthi uma sekuhlangene kube neqhaza elikhulu kulesi sifo esiyinkimbinkimbi futhi esinezici eziningi njengomdlavuza.
Eminyakeni embalwa edlule, amaqembu amaningi ocwaningo anamandla kakhulu emhlabeni, azi ngale nkinga, aqale ukuhlanganyela emizamweni yokuthola nokuchaza yonke le miphumela. UHerman ukhulume ngomunye walezi zinhlelo (I-PanCancer Atlas) kanye nemiphumela etholwe njengengxenye yomsebenzi wale nhlangano yamalabhorethri futhi yashicilelwa kumagazini okhethekile weCell kule nkulumo.
4. I-ChIP-Seq ekutadisheni izindlela ze-epigenetic | U-Oleg Shpynov, Ucwaningo lwe-JetBrains
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Ukulawulwa kokuvezwa kwezakhi zofuzo kwenziwa ngezindlela ezahlukene. Enkulumweni yakhe, u-Oleg wakhuluma ngokulawulwa kwe-epigenetic ngokusebenzisa ukuguqulwa kwe-histone, ukutadisha kwalezi zinqubo usebenzisa indlela ye-ChIP-seq nezindlela zokuhlaziya imiphumela etholiwe.
5. I-Multiomics ocwaningweni lweCancer | UKonstantin Okonechnikov, Isikhungo Sokucwaninga Ngomdlavuza saseJalimane
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Ukuthuthukiswa kobuchwepheshe bokuhlola kubhayoloji yamangqamuzana kwenze kwaba nokwenzeka ukuhlanganisa ucwaningo lwezinqubo ezihlukahlukene zokusebenza kumaseli, izitho zomzimba noma imbala yonke into ephilayo. Ukusungula ukuxhumana phakathi kwezingxenye zezinqubo zebhayoloji, kuyadingeka ukusebenzisa i-multiomics, ehlanganisa idatha yokuhlola enkulu evela ku-genomics, transcriptomics, epigenomics kanye ne-proteomics. UKonstantin unikeze izibonelo ezicacile zokusebenzisa ama-multi-omics emkhakheni wocwaningo lomdlavuza ngokugxila ku-oncology yezingane.
6. Ukuhlukahluka kanye Nemikhawulo Yokuhlaziywa Kweseli Elilodwa | Konstantin Okonechnikov
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Inkulumo enemininingwane eminingi nge-single-cell RNA-seq nezindlela zokuhlaziya le datha, kanye nezindlela zokunqoba izinkinga ezisobala nezifihliwe lapho uzifundela.
7. Ukuhlaziywa kwedatha yeseli eyodwa ye-RNA-seq | Konstantin Zaitsev, Washington University e-St
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Inkulumo eyisingeniso yokulandelana kweseli elilodwa. U-Konstantin uxoxa ngezindlela zokulandelana, ubunzima emsebenzini waselabhorethri kanye nokuhlaziywa kwe-bioinformatics, nezindlela zokuzinqoba.
8. Ukuxilongwa kwe-muscular dystrophy usebenzisa ukulandelana kwe-nanopore | Pavel Avdeev, George Washington University
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Ukulandelanisa kusetshenziswa ubuchwepheshe be-Oxford Nanopore kunezinzuzo ezingasetshenziswa ukukhomba izimbangela zofuzo zezifo ezifana ne-muscular dystrophy. Enkulumweni yakhe, uPavel wakhuluma ngokusungulwa kwepayipi lokuxilonga lesi sifo.
9*. Ukumelwa kwegrafu ye-genome | Ilya Minkin, Pennsylvania State University
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Amamodeli wegrafu avumela ukumelwa okuhlangene kwenani elikhulu lokulandelana okufanayo futhi avame ukusetshenziswa kuma-genomics. U-Ilya ukhulume ngokuningiliziwe ngokuthi ukulandelana kwe-genomic kwakhiwa kanjani kabusha kusetshenziswa amagrafu, ukuthi igrafu ye-de Bruin isetshenziswa kanjani futhi kungani, indlela enjalo "yegrafu" ikwandisa kangakanani ukunemba kokusesha kokuguqulwa kwezakhi zofuzo, futhi yiziphi izinkinga ezingaxazululiwe ngokusetshenziswa kwamagrafu ezisekhona.
10*. Ama-proteomics ajabulisayo | UPavel Sinitsyn, iMax Planck Institute of Biochemistry (izingxenye ezi-2)
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Amaprotheni anesibopho sezinqubo eziningi ze-biochemical entweni ephilayo, futhi kuze kube manje i-proteomics iwukuphela kwendlela yokuhlaziya isimo sezinkulungwane zamaphrotheni ngesikhathi esisodwa emhlabeni jikelele. Ububanzi bezinkinga ezixazululiwe buyamangalisa - kusukela ekuboneni amasosha omzimba nama-antigens kuya ekunqumeni ukwenziwa kwendawo kwamaprotheni ayizinkulungwane ezimbalwa. Ezifundweni zakhe, u-Pavel wakhuluma ngalokhu kanye nezinye izinhlelo zokusebenza ze-proteomics, ukuthuthukiswa kwayo kwamanje kanye nezingibe ekuhlaziyeni idatha.
ishumi nanye*. Izimiso eziyisisekelo zokulingiswa kwamangqamuzana | Pavel Yakovlev, BIOCAD
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Isifundo sethiyori esiyisethulo mayelana nokuguquguquka kwamangqamuzana: kungani idingeka, ukuthi yenzani nokuthi isetshenziswa kanjani maqondana nokuthuthukiswa kwezidakamizwa. U-Pavel unake izindlela zokuguquguquka kwamangqamuzana, incazelo yamandla amangqamuzana, incazelo yokuxhumana, imiqondo "yenkambu yamandla" kanye "nokuhlanganiswa", imikhawulo ekumodeleni, nokunye okuningi.
12*. I-Molecular Biology kanye neGenetics | Yuri Barbitov, Institute of Bioinformatics
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Isethulo esinezingxenye ezintathu sebhayoloji yamangqamuzana nezakhi zofuzo zabafundi bonjiniyela kanye nabathweswe iziqu. Inkulumo yokuqala idingida imiqondo yebhayoloji yesimanje, izindaba zokwakheka kofuzo kanye nokuvela koguquko. Eyesibili ihlanganisa ngokuningiliziwe izindaba zokusebenza kwezakhi zofuzo, izinqubo zokuloba nokuhumusha, eyesithathu ihlanganisa ukulawulwa kokuvezwa kofuzo nezindlela eziyisisekelo zebhayoloji yamangqamuzana.
13*. Izimiso Zokuhlaziywa Kwedatha ye-NGS | Yuri Barbitov, Institute of Bioinformatics
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Inkulumo ichaza izindlela zokulandelana kwesizukulwane sesibili (NGS), izinhlobo nezici zazo. Umfundisi uchaza ngokuningiliziwe ukuthi idatha "yomphumela" ovela ku-sequencer yakhiwe kanjani, ukuthi iguqulwa kanjani ukuze ihlaziywe, nokuthi yiziphi izindlela zokusebenzisana nayo.
14*. Usebenzisa umugqa womyalo, zijwayeze | Gennady Zakharov, EPAM
Ukubuka konke okusebenzayo kwemiyalo yomugqa womyalo we-Linux, izinketho kanye nezisekelo zokuyisebenzisa. Izibonelo zigxile ekuhlaziyweni kokulandelana kwe-DNA. Ngokungeziwe ekusebenzeni okujwayelekile kwe-Linux (isibonelo, ikati, i-grep, i-sed, i-awk), izinsiza zokusebenza ngokulandelana (ama-samtools, amathuluzi okulala) ayacatshangelwa.
15*. Ukubukwa kwedatha kwabancane | Nikita Alekseev, ITMO University
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Wonke umuntu ube nolwazi lokuveza imiphumela yephrojekthi yakhe yesayensi noma ukuqonda imidwebo yabanye abantu, amagrafu nezithombe. U-Nikita utshele indlela yokuhumusha kahle amagrafu nemidwebo, eqokomisa into eyinhloko kubo; indlela yokudweba izithombe ezicacile. Umfundisi uphinde wagcizelela ukuthi yini okufanele ibheke lapho ufunda indatshana noma ubuka intengiso.
16*. Imisebenzi ku-Bioinformatics | UVictoria Korzhova, iMax Planck Institute of Biochemistry
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UVictoria ukhulume ngesakhiwo sesayensi yezemfundo phesheya nokuthi yini okudingeka uyinake ukuze wakhe umsebenzi wesayensi noma imboni njengomfundi oneziqu, oneziqu noma oneziqu.
17*. Ibhalwa kanjani i-CV kasosayensi | UVictoria Korzhova, iMax Planck Institute of Biochemistry
Yini okufanele uyishiye ku-CV futhi yini okufanele uyisuse? Yimaphi amaqiniso azoba nentshisekelo kumphathi welebhu ongase abe khona, futhi yimaphi angcono ukungawasho? Kufanele uluhlele kanjani ulwazi ukuze wenze ukuqhubeka kwakho kugqame? Isifundo sizonikeza izimpendulo zale mibuzo neminye.
18*. Isebenza kanjani imakethe ye-bioinformatics | Andrey Afanasyev, yRisk
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Isebenza kanjani imakethe futhi ingasebenza kuphi i-bioinformatics? Impendulo yalo mbuzo inikezwa ngokuningiliziwe, ngezibonelo nezeluleko, enkulumweni ka-Andrey.
I-ΠΠΎΠ½Π΅Ρ
Njengoba ungase uqaphele, izinkulumo esikoleni zibanzi kakhulu ezihlokweni - kusukela ekumodeleni kwamangqamuzana nokusetshenziswa kwamagrafu ekuhlanganiseni kofuzo, kuye ekuhlaziyweni kwamangqamuzana angawodwa kanye nokwakha umsebenzi wesayensi. Thina e-Institute of Bioinformatics sizama ukufaka izihloko ezihlukahlukene ohlelweni lwesikole ukuze sihlanganise imikhakha eminingi ye-bioinformatics ngangokunokwenzeka, futhi ukuze umhlanganyeli ngamunye afunde okuthile okusha nokuwusizo.
Isikole esilandelayo se-bioinformatics sizoba kusukela ngoJulayi 29 kuya ku-Agasti 3, 2019 eduze kwaseMoscow. . Isihloko salo nyaka sizoba yi-bioinformatics in developmental biology kanye nocwaningo lokuguga.
Kulabo abafuna ukufunda i-bioinformatics ngokujulile, sisazamukela izicelo zethu eSt. Petersburg. Noma landela izindaba zethu mayelana nokuvulwa kohlelo eMoscow kulokhu kuwa.
Kulabo abangekho eSt. Petersburg noma eMoscow, kodwa abafuna ngempela ukuba yi-bioinformamatician, silungiselele kuma-algorithms, izinhlelo, izakhi zofuzo kanye nebhayoloji.
Siphinde sibe namashumi , ongaqala ukudlula kukho manje.
Ngo-2018, isikole sasehlobo se-bioinformatics sabanjwa ngokusekelwa abalingani bethu abavamile - izinkampani i-JetBrains, i-BIOCAD ne-EPAM, esibabonga kakhulu ngayo.
Bioinformatics wonke umuntu!
PS Uma ubungacabangi ukuthi kwanele, ΠΈ .
Source: www.habr.com