Ithimba labacwaningi abavela kwa-ETH Zurich eSwitzerland i-biosynthetic dual-core processor yokuqala eyake yenziwa kuseli lomuntu. Ukuze benze lokhu, basebenzisa indlela ye-CRISPR-Cas9, esetshenziswa kabanzi ku-genetic engineering, lapho amaprotheni e-Cas9, esebenzisa okulawulwayo futhi, omunye angase athi, izenzo ezihleliwe, ukuguqula, ukukhumbula noma ukuhlola i-DNA yangaphandle. Futhi njengoba izenzo zingahlelwa, kungani ungaguquli indlela ye-CRISPR ukuze isebenze ngokufana namasango edijithali?
Ososayensi baseSwitzerland abaholwa umholi wephrojekthi uSolwazi Martin Fussenegger bakwazile ukufaka ukulandelana kwe-CRISPR DNA okubili kusuka kumagciwane amabili ahlukene kuseli lomuntu. Ngaphansi kwethonya lephrotheni ye-Cas9 futhi kuye ngamaketanga e-RNA anikezwa iseli, ukulandelana ngakunye kukhiqize amaprotheni ayo ahlukile. Ngakho-ke, lokho okubizwa ngokuthi ukubonakaliswa kofuzo okulawulwayo kwenzeka, lapho, ngokusekelwe olwazini olulotshwe ku-DNA, kwakhiwa umkhiqizo omusha - amaprotheni noma i-RNA. Ngokufanisa namanethiwekhi edijithali, inqubo eyakhiwe ososayensi baseSwitzerland ingamelwa njenge-half-adder enengqondo enezimpendulo ezimbili kanye nemiphumela emibili. Isignali yokuphumayo (okuhlukile kwamaprotheni) incike kumasignali okokufaka amabili.
Izinqubo zebhayoloji kumaseli aphilayo azikwazi ukuqhathaniswa namasekhethi ekhompyutha yedijithali ngokwejubane lokusebenza. Kodwa amangqamuzana angasebenza ngezinga eliphakeme kakhulu lokufana, acubungula ama-molecule afika ku-100 ngesikhathi. Cabanga ngezicubu eziphilayo ezinezigidi “zama-dual-core” processors. Ikhompiyutha enjalo inganikeza ukusebenza okumangalisayo ngisho nangezindinganiso zesimanje. Kodwa ngisho noma sibeka eceleni ukwakhiwa kwama-supercomputers “aqondile,” amabhlogo okwenziwa anengqondo akhiwe emzimbeni womuntu angasiza ekuxilongeni nasekwelapheni izifo, kuhlanganise nomdlavuza.
Amabhulokhi anjalo angakwazi ukucubungula ulwazi lwebhayoloji emzimbeni womuntu njengokufakwayo futhi akhiqize kokubili amasiginali okuxilonga kanye nokulandelana kwemithi. Uma inqubo ye-metastase iqala, isibonelo, izifunda ezinengqondo zokwenziwa zingaqala ukukhiqiza ama-enzyme acindezela umdlavuza. Kunezicelo eziningi zalesi simo, futhi ukusetshenziswa kwayo kungashintsha umuntu nomhlaba.
Source: 3dnews.ru